A Therapeutic Side Effect on Hydatid Cyst after Lung Cancer Treatment: A Case Report
Abstract
Cystic echinococcus (CE) is an important health problem affecting societies living especially in rural areas. Our patient was a 64-year-old male who received PAIR treatment and albendazole treatment for CE at Haydarpaşa Numune Training and Research Hospital, Istanbul, Turkey between 2022 and 2025. The patient was first operated on for lung cancer. After treatment, the patient continues to live asymptomatically in the 36-month follow-up. We observed and followed up that the paxlitaxel and carboplatin treatments received by our patient caused regression in the CE lesions. We think that the effectiveness of this situation should be evaluated first with experimental studies.
1. Wen H, Vuitton L, Tuxun T, et al. Echinococcosis: advances in the 21st century. Clin Microbiol Rev. 2019;32(2):10.1128/cmr. 00075-18.
2. Budke CM, Carabin H, Ndimubanzi PC, et al. A systematic review of the literature on cystic echinococcosis frequency worldwide and its associated clinical manifestations. Am J Trop Med Hyg. 2013;88(6):1011-27.
3. Ismail IB, Zaafouri EB, Zenaidi H, Rebii S, Zoghlami A. Acute peritonitis secondary to spontaneous rupture of hepatic hydatid cyst: A case report and literature review. IDCases. 2025:e02166.
4. Jedidi M, Mlayeh S, Masmoudi T, Souguir MK, Zemni M. Sudden death due to hydatid cyst: thirty-four medicolegal autopsy cases. Am J Forensic Med Pathol. 2014;35(1):29-33.
5. Özdemir Y, Ozer İ, Sürmelioğlu A, et al. Risk factors determining bile leakage after multiple liver hydatid cyst surgery. JOSAM. 2022;6(3):306-12.
6. Pavlidis ET, Galanis IN, Pavlidis TE. Current considerations for the management of liver echinococcosis. World J Gastroenterol. 2025;31(10):103973.
7. Öztürk G, Uzun MA, Özkan ÖF, et al. Turkish HPB Surgery Association consensus report on hepatic cystic echinococcosis (HCE). Turk J Surg. 2022;38(2):101-120.
8. Sokouti M, Sadeghi R, Pashazadeh S, et al. A systematic review and meta-analysis on the treatment of liver hydatid cyst using meta-MUMS tool: comparing PAIR and laparoscopic procedures. Arch Med Sci. 2019;15(2):284-308.
9. Uzunoğlu H, Gül M. A case report of liver and pancreatic echinococcal cysts. Niger J Clin Pract. 2022;25(1):114-7.
10. Hassanzadeh E, Khademvatan S, Jafari B, Jafari A, Yousefi E. In vitro and in silico scolicidal effect of sanguinarine on the hydatid cyst protoscoleces. Plos One. 2023;18(10):e0290947.
11. Sorouri N, Soleymani N, Sadr S, Rahdar A, Ebrahimzadeh E, Borji H. Investigating the therapeutic effects of curcumin nanocapsules in hydatid cyst-infected mice. Exp Parasitol. 2024;267:108860.
12. Sadr S, Lotfalizadeh N, Abbasi AM, et al. Challenges and prospective of enhancing hydatid cyst chemotherapy by nanotechnology and the future of nanobiosensors for diagnosis. Trop Med Infect Dis. 2023;8(11):494.
13. Chai JY, Jung BK, Hong SJ. Albendazole and mebendazole as anti-parasitic and anti-cancer agents: an update. Korean J Parasitol. 2021;59(3):189-225.
14. Pensel PE, Albani C, Gamboa GU, Benoit JP, Elissondo MC. In vitro effect of 5-fluorouracil and paclitaxel on Echinococcus granulosus larvae and cells. Acta Trop. 2014;140:1-9.
15. Bangaru SD, Kozarsky PE, Lee DJ, Sica GL, Owonikoko TK. A bystander effect of lung cancer chemotherapy on chronic echinococcal disease. World J Oncol. 2015;6(4):416-420.
16. Mahjoub Y, Boussaid M, Mesrati MA, et al. Hydatid disease, an uncommon etiology of death in forensic practice. Am J Forensic Med Pathol. 2022;43(2):121-5.
17. Batzlaff CM, Pupaibool J, Sohail MR. Acute renal failure associated with albendazole therapy in a patient with trichinosis. BMJ Case Rep. 2014;2014:bcr2013200668.
18. Moon SY, Baek YH, Lee SW. Drug induced liver injury by prophylactic administration of albendazole. Korean J Gastroenterol. 2019;73(6):360-4.
19. Soleymani N, Sadr S, Santucciu C, Rahdar A, Masala G, Borji H. Evaluation of the In-Vitro Effects of Albendazole, Mebendazole, and Praziquantel Nanocapsules against Protoscolices of Hydatid Cyst. Pathogens. 2024;13(9):790.
20. Gao H, Xu Q, Zhu J, et al. Efficacy and mechanism of action of harmine derivative H-2-104 against Echinococcus granulosus infection in mice. BMC Vet Res. 2025;21(1):174.
2. Budke CM, Carabin H, Ndimubanzi PC, et al. A systematic review of the literature on cystic echinococcosis frequency worldwide and its associated clinical manifestations. Am J Trop Med Hyg. 2013;88(6):1011-27.
3. Ismail IB, Zaafouri EB, Zenaidi H, Rebii S, Zoghlami A. Acute peritonitis secondary to spontaneous rupture of hepatic hydatid cyst: A case report and literature review. IDCases. 2025:e02166.
4. Jedidi M, Mlayeh S, Masmoudi T, Souguir MK, Zemni M. Sudden death due to hydatid cyst: thirty-four medicolegal autopsy cases. Am J Forensic Med Pathol. 2014;35(1):29-33.
5. Özdemir Y, Ozer İ, Sürmelioğlu A, et al. Risk factors determining bile leakage after multiple liver hydatid cyst surgery. JOSAM. 2022;6(3):306-12.
6. Pavlidis ET, Galanis IN, Pavlidis TE. Current considerations for the management of liver echinococcosis. World J Gastroenterol. 2025;31(10):103973.
7. Öztürk G, Uzun MA, Özkan ÖF, et al. Turkish HPB Surgery Association consensus report on hepatic cystic echinococcosis (HCE). Turk J Surg. 2022;38(2):101-120.
8. Sokouti M, Sadeghi R, Pashazadeh S, et al. A systematic review and meta-analysis on the treatment of liver hydatid cyst using meta-MUMS tool: comparing PAIR and laparoscopic procedures. Arch Med Sci. 2019;15(2):284-308.
9. Uzunoğlu H, Gül M. A case report of liver and pancreatic echinococcal cysts. Niger J Clin Pract. 2022;25(1):114-7.
10. Hassanzadeh E, Khademvatan S, Jafari B, Jafari A, Yousefi E. In vitro and in silico scolicidal effect of sanguinarine on the hydatid cyst protoscoleces. Plos One. 2023;18(10):e0290947.
11. Sorouri N, Soleymani N, Sadr S, Rahdar A, Ebrahimzadeh E, Borji H. Investigating the therapeutic effects of curcumin nanocapsules in hydatid cyst-infected mice. Exp Parasitol. 2024;267:108860.
12. Sadr S, Lotfalizadeh N, Abbasi AM, et al. Challenges and prospective of enhancing hydatid cyst chemotherapy by nanotechnology and the future of nanobiosensors for diagnosis. Trop Med Infect Dis. 2023;8(11):494.
13. Chai JY, Jung BK, Hong SJ. Albendazole and mebendazole as anti-parasitic and anti-cancer agents: an update. Korean J Parasitol. 2021;59(3):189-225.
14. Pensel PE, Albani C, Gamboa GU, Benoit JP, Elissondo MC. In vitro effect of 5-fluorouracil and paclitaxel on Echinococcus granulosus larvae and cells. Acta Trop. 2014;140:1-9.
15. Bangaru SD, Kozarsky PE, Lee DJ, Sica GL, Owonikoko TK. A bystander effect of lung cancer chemotherapy on chronic echinococcal disease. World J Oncol. 2015;6(4):416-420.
16. Mahjoub Y, Boussaid M, Mesrati MA, et al. Hydatid disease, an uncommon etiology of death in forensic practice. Am J Forensic Med Pathol. 2022;43(2):121-5.
17. Batzlaff CM, Pupaibool J, Sohail MR. Acute renal failure associated with albendazole therapy in a patient with trichinosis. BMJ Case Rep. 2014;2014:bcr2013200668.
18. Moon SY, Baek YH, Lee SW. Drug induced liver injury by prophylactic administration of albendazole. Korean J Gastroenterol. 2019;73(6):360-4.
19. Soleymani N, Sadr S, Santucciu C, Rahdar A, Masala G, Borji H. Evaluation of the In-Vitro Effects of Albendazole, Mebendazole, and Praziquantel Nanocapsules against Protoscolices of Hydatid Cyst. Pathogens. 2024;13(9):790.
20. Gao H, Xu Q, Zhu J, et al. Efficacy and mechanism of action of harmine derivative H-2-104 against Echinococcus granulosus infection in mice. BMC Vet Res. 2025;21(1):174.
| Files | ||
| Issue | Vol 21 No 1 (2026) | |
| Section | Case Report(s) | |
| DOI | https://doi.org/10.18502/ijpa.v21i1.21641 | |
| Keywords | ||
| Chemotherapy Cystic echinococcus Positive side effect Treatment | ||
| Rights and permissions | |
|
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Akyuz C, Çorbaci K. A Therapeutic Side Effect on Hydatid Cyst after Lung Cancer Treatment: A Case Report. Iran J Parasitol. 2026;21(1):125-129.
