Short Communication

Frequency of Toxocara Antibodies in Patients Clinically Suspected to Ocular Toxocariasis, Northeast of Iran

Abstract

Background: Human toxocariasis is a neglected parasitic disease in most countries including Iran. Among different clinical forms of toxocariasis, ocular toxocariasis (OT) is an important disease resulting in severe vision loss. However, the prevalence and incidence of OT are currently unclear in Iran. This study aimed to determine the prevalence of ocular toxocariasis among patients with uveitis in the Northeast of Iran.

Methods: From 2015 to 2017, 510 patients with uveitis referred to Khatam-al-Anbia, a tertiary eye hospital at Mashhad, Iran were examined for OT. Serum samples of the suspected patients were obtained and evaluated for IgG against Toxocara canis using ELISA test. Anti-Toxocara IgG positive serums were further investigated using confirmatory Western blotting (WB) analysis.

Results: Twenty patients had pathologic changes and clinical presentations in the anterior and posterior segments of their eyes and they were clinically diagnosed ocular toxocariasis. Among the 20 patients, 2 (10%) patients showed IgG antibody against Toxocara canis on ELISA as well as on WB test. The calculated prevalence of ocular toxocariasis was about 0.4%.

Conclusion: Ocular toxocariasis can be diagnosed both clinically and serologically in Mashhad, northeastern Iran. Although OT is a rare pathologic eye disease, it should be considered as one of the important cause of infectious posterior uveitis.

1. Mervyn RH tylor , Ocular Toxocariasis in: Holland C, Smith HV. Toxocara: the enigmatic parasite. 2006; sec.2, chap.9:127-144 CABI.
2. Choi D, Lim JH, Choi D-C, et al. Transmission of Toxocara canis via ingestion of raw cow liver: a cross-sectional study in healthy adults. Korean J Parasitol. 2012;50(1): 23-27.
3. Taylor M. The epidemiology of ocular toxocariasis. J Helminthol. 2001;75(2):109-118.
4. Sharkey JA, McKay PS. Ocular toxocariasis in a patient with repeatedly negative ELISA titre to Toxocara canis. Br J Ophthalmol. 1993;77(4):253-4.
5. Ahn SJ, Ryoo NK, Woo SJ. Ocular toxocariasis: clinical features, diagnosis, treatment, and prevention. Asia Pac Allergy. 2014;4(3):134–141.
6. Oryan A, Alidadi S. Toxocariasis: A Neglected Parasitic Disease with Public Health Importance. Trop Med Surg. 2015;3(2). DOI:10.4172/2329-9088.1000126
7. Despommier D. Toxocariasis: clinical aspects, epidemiology, medical ecology, and molecular aspects. Clin Microbiol Rev. 2003;16(2):265-272.
8. Rubinsky-Elefant G, Hirata CE, Yamamoto JH, et al. Human toxocariasis: diagnosis, worldwide seroprevalences and clinical expression of the systemic and ocular forms. Ann Trop Med Parasitol. 2010;104(1):3-23.
9. Yokoi K, Goto H, Sakai J-I, et al. Clinical features of ocular toxocariasis in Japan. Ocul Immunol Inflamm. 2003;11(4):269-275.
10. Kwon SI, Lee JP, Park SP, et al. Ocular toxocariasis in Korea. Jpn J Ophthalmol. 2011;55(2):143-147.
11. Arevalo JF, Espinoza JV, Arevalo FA. Ocular toxocariasis. J Pediatr Ophthalmol Strabismus. 2012; 50(2): 76-86.
12. Zibaei M, Sadjjadi SM. Trend of toxocariasis in Iran: a review on human and animal dimensions. Iran J Vet Res. 2017;18(4):233-242.
13. Zibaei M, Sadjjadi SM, Jahadi-Hosseini SH. Toxocara cati larvae in the eye of a child: a case report. Asian Pac J Trop Biomed. 2014;4(Suppl 1):S53-S55.
14. Zibaei M, Alemi M, Cardillo NM, et al. Human toxocariasis seroprevalence amongpatients with uveitis in Alborz Province, Iran.Ann Agric Environ Med. 2019;26(1):154–158.
15. Berenji F, Pouryousef A, Fata A, et al. Seroepidemiological Study of Toxocariasis in the Owners of Domestic Cats and Dogs in Mashhad, Northeastern Iran. Iran J Parasitol. 2016;11(2):265-268.
16. Sharif M, Daryani A, Barzegar G, et al. Seroprevalence of toxocariasis in schoolchildren in Northern Iran. Pak J Biol Sci. 2010;13(4):180-184.
17. Berenji F, Rudy Movahedi AGH, Fata A, et al. Soil Contamination with Toxocara Spp. Eggs in Public Parks of Mashhad and Khaf, North East of Iran. Iran J Parasitol. 2015;10(2):286-289.
18. Abdi J, Darabi M, Sayehmiri K. Epidemiological situation of toxocariasis in Iran: meta-analysis and systematic review. Pak J Biol Sci. 2012;15(22):1052-5.
19. Sharif M, Nasrolahei M, Ziapour S, et al. Toxocara cati infections in stray cats in northern Iran. J Helminthol. 2007;81(1):63-66.
20. Ahn SJ, Woo SJ, Jin Y, et al. Clinical features and course of ocular toxocariasis in adults. PLoS Negl Trop Dis. 2014;8(6):e2938.
21. Stewart JM, Cubillan LD, Cunningham ET Jr. Prevalence, clinical features, and causes of vision loss among patients with ocular toxocariasis. Retina. 2005;25(8):1005-1013.
22. Jones JL, Kruszon-Moran D, Won K, et al. Toxoplasma gondii and Toxocara spp. co-infection. Am J Trop Med Hyg. 2008;78(1):35-39.
23. Hossini S, Moghaddas E, sharifi K, et al. Assessment of Ocular Toxoplasmosis patients Reported at a Tertiary Centre in the Northeast of Iran. Int Ophthalmol. 2018;38(1).
24. Otranto D, Eberhard ML. Zoonotic helminths affecting the human eye. Parasit Vectors. 2011;4:41.
25. Paul M, Stefaniak J, Twardosz-Pawlik H, et al. The co-occurrence of Toxocara ocular and visceral larva migrans syndrome: a case series. Cases J. 2009;2:6881.
26. Lescano SAZ, Nakhle MC, Ribeiro MCS, et al. IgG antibody responses in mice coinfected with Toxocara canis and other helminths or protozoan parasites. Rev Inst Med Trop Sao Paulo. 2012;54(3):145-152.
27. Zarnowska H, Jastrzebska M. Excretory-secretory larval antigens of Toxocara canis: physico-chemical characteristics and specificity assayed by Western blot technique. Acta Parasitol. 1994; 39(1): 41-45.
28. Fonseca C, MendesSilva A, Freire S, et al. Ocular toxocariasis: atypical clinical course. BMJ Case Rep. 2019;12(4):e228717.
29. Cortez RT, Ramirez G, Collet L, et al. Ocular parasitic diseases: a review on toxocariasis and diffuse unilateral subacute neuroretinitis. J Pediatr Ophthalmol Strabismus. 2011;48(4):204-212.
30. Glickman L,Schantz PM. Epidemiology and pathogenesis of zoonotic toxocariasis. Epidemiol Rev. 1981;3:230-250.
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IssueVol 16 No 2 (2021) QRcode
SectionShort Communication(s)
Published2021-05-28
DOI https://doi.org/10.18502/ijpa.v16i2.6312
Keywords
Toxocariasis Uveitis Western blotting

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How to Cite
1.
Fata A, Hosseini SM, Woo SJ, Zibaei M, Berenji F, Hosseini Farash BR, Moghaddas E. Frequency of Toxocara Antibodies in Patients Clinically Suspected to Ocular Toxocariasis, Northeast of Iran. Iran J Parasitol. 16(2):305-311.