Original Article

Seroprevalence of Human Fasciolosis in Lorestan Province, Western Iran, in 2015-16


Background: The aim of this study was the seroepidemiological survey for detecting the status of human fasciolosis in Lorestan Province, western Iran.

Methods: This cross-sectional study was conducted in 2015-16. Based on statistical estimations, 1256 serum samples were collected from different parts of Lorestan Province, western Iran, and stored at -20 °C until use. The collected serum samples were analyzed at Tehran University of Medical Sciences, Tehran, Iran using indirect ELISA method.

Results: Anti-Fasciola antibodies were detected in 16 (1.3%) individuals. Regarding the seropositivity to fasciolosis, no significant differences were found between age groups, sex, level of education and occupation; however significant differences were observed regarding location, consuming local freshwater plants and water resources (P<0.02.)

Conclusion: Local freshwater plants and unfiltered water resources were probably the main sources of the infection. Health education by local health centers to elevate awareness of people, and providing facilities for safer drinking water, especially in rural areas may help decrease the risk of fasciolosis infection in this region.

Rokni MB, Lotfy WM, Ashrafi K et al. Fasciolosis in the MENA region. Neglected Tropical Diseases-Middle East and North Africa. Springer; 2014:59-90.

Mas-Coma S. Epidemiology of fascioliasis in human endemic areas. J Helminthol. 2005; 79(3):207-16.

Mas-Coma S, Valero MA, Bargues MD.. Fasciola, lymnaeids and human fascioliasis, with a global overview on disease transmission, epidemiology, evolutionary genetics, molecular epidemiology and control. Adv Parasitol. 2009;69:41-146.

González LC, Esteban JG, Bargues MD et al. Hyperendemic human fascioliasis in Andean valleys: An altitudinal transect analysis in children of Cajamarca Province, Peru. Acta Trop. 2011;120(1-2):119-29.

Sripa B, Kaewkes S, Intapan PM et al. Food-borne trematodiases in Southeast Asia: Epidemiology, pathology, clinical manifestation and control. Adv Parasitol. 2010;72:305-50.

Mas-Coma MS, Esteban JG, Bargues MD. Epidemiology of human fascioliasis: A review and proposed new classification. Bull World Health Organ. 1999;77(4):340-6.

Mas-Coma S. Human fascioliasis: Epidemiological patterns in human endemic areas of South America, Africa and Asia. Southeast Asian J Trop Med Public Health. 2004;35:1-11.

Daumerie D, Savioli L. Working to overcome the global impact of neglected tropical diseases: First who report on neglected tropical diseases. World Health Organization; 2010.

Dowlati Y, Dowlati A, Seyyedi B. Cutaneous fascioliasis. Medical Journal of The Islamic Republic of Iran (MJIRI). 1987;1:62-65.

Hanjani A, Nikakhtar B, Arfaa F et al. A case of infection with Fasciola hepatica with allergic manifestations. Acta Med Iranica. 1971:149-151.

Farid H. Human infection with Fasciola hepatica and Dicrocoelium dendriticum in Isfahan area, central Iran. J Parasitol. 1971;57.

Neshat H, Eslami A. The importance and incidence of food born helminth infections in man, in Iran. Iran J Public Health. 1976;5:56-61.

Moghaddam AS, Massoud J, Mahmoodi M et al. Human and animal fascioliasis in Mazandaran Province, northern Iran. Parasitol Res. 2004; 94(1):61-9.

Hatami H, Asmar M, Masoud J et al. The first epidemic and new-emerging human fascioliasis in Kermanshah (western Iran) and a ten-year follow up, 1998-2008. Int J Prev Med. 3(4):266-72.

Sarkari B, Ghobakhloo N, Moshfea AA et al. Seroprevalence of human fasciolosis in a new-emerging focus of fasciolosis in Yasuj district, southwest of Iran. Iran J Parasitol. 2012; 7(2): 15–20.

Ashrafi K. The status of human and animal fascioliasis in Iran: A narrative review article. Iran J Parasitol. 2015; 10(3): 306–328.

Rokni MB, Massoud J, O’Neill SM et al. Diagnosis of human fasciolosis in the gilan province of northern Iran: Application of cathepsin l-ELISA. Diag Microbiol Infect Dis. 2002;44:175-179.

Rahimi MT, Ashrafi K, Koosha S et al. Evaluation of fast-elisa versus standard-ELISA to diagnose human fasciolosis. Arch Iran Med. 2011; 14(1):18-21.

Farnaz Kheirandish, Mohammad Hassan Kayed, Behrouz Ezatpour et al. Seroprevalence of human fasciolosis in Pirabad, Lorestan Province, western. Iran J Parasitol. 2016;11(1): 24–29.

Rokni MB. The present status of human helminthic diseases in Iran. Ann Trop Med Parasitol. 2008; 102(4):283-95.

Esteban JG, Flores A, Angles R et al. High endemicity of human fascioliasis between Lake Titicaca and La Paz Valley, Bolivia. Trans R Soc Trop Med Hyg. 1999; 93(2):151-6.

Esteban J-g, Gonzalez C, Curtale F et al. Hyperendemic fascioliasis associated with schistosomiasis in villages in the Nile Delta of Egypt. Am J Trop Med Hyg. 2003; 69(4):429-37.

Forghan PK, Yadegari D, Asmar M. Study of clinical epidemiology of fascioliasis in Guilan. Iran J Public Health. 2015; 44(4): 501–511.

Periago MV, Valero MA, El Sayed M et al. First phenotypic description of Fasciola hepatica/Fasciola gigantica intermediate forms from the human endemic area of the Nile Delta, Egypt. Infect Genet Evol. 2008; 8(1):51-8.

Saberinasab M, Mohebali M, Molawi G et al. Seroprevalence of human fascioliasis using indirect ELISA in Isfahan district, central Iran in 2013. Iran J Parasitol. 2014; 9(4):461-5.

Asadian S, Mohebali M, Moudi M et al. Seroprevalence of human fascioliasis in Meshkin-Shahr District, Ardabil Province, northwestern Iran in 2012. Iran J Parasitol. 2013; 8(4):516-21.

Abdi J, Naserifar R, Rostami Nejad M et al. New features of fascioliasis in human and animal infections in Ilam Province, Western Iran. Gastroenterol Hepatol Bed Bench. 2013; 6(3):152-5.

Ashrafi K, Saadat F, O'Neill S et al. The endemicity of human fascioliasis in Guilan Province, Northern Iran: The baseline for implementation of control strategies. Iran J Public Health. 2015; 44(4):501-11.

Esteban JG, Flores A, Aguirre C et al. Presence of very high prevalence and intensity of infection with Fasciola hepatica among aymara children from the northern Bolivian Altiplano. Acta Trop. 1997; 66(1):1-14.

Kaplan M, Kuk S, Kalkan A et al. Fasciola hepatica seroprevalence in the Elazig Region. Mikrobiyol Bul. 2002; 36(3-4):337-42.

O'Neill SM, Parkinson M, Strauss W et al. Immunodiagnosis of Fasciola hepatica infection (fascioliasis) in a human population in the Bolivian Altiplano using purified cathepsin l cysteine proteinase. Am J Trop Med Hyg. 1998; 58(4):417-23.

Qureshi AW, Tanveer A, Qureshi S et al. Epidemiology of human fasciolosis in rural areas of Lahore, Pakistan. Punjab Univ J Zool. 2005;20:159-168.

Zumaquero-Ríos JL, Sarracent-Pérez J, Rojas-García R et al. Fascioliasis and intestinal parasitoses affecting schoolchildren in Atlixco, Puebla State, Mexico: Epidemiology and treatment with nitazoxanide. PLoS Negl Trop Dis. 2013; 7(11):e2553.

Assmar M, Milaninia A, Amirkhani A et al. Seroepidemiological investigation of fascioliasis in northern Iran. Medical Journal of The Islamic Republic of Iran (MJIRI). 1991;5:23-27.

Forghan-parast K, Yadegari D, Asmar M. Clinical epidemiology of human fascioliasis in Gilan. Journal of Gilan University of Medical Sciences. 1993;6:4-11.

Ashrafi K, Valero MA, Massoud J et al. Plant-borne human contamination by fascioliasis. Am J Trop Med Hyg. 2006; 75(2):295-302.

Mas-Coma S, Bargues MD, Valero MA. Fascioliasis and other plant-borne trematode zoonoses. Int J Parasitol. 2005; 35(11-12):1255-78.

Ashrafi K, MA Valero K, Forghan-Parast M et al. Potential transmission of human fascioliasis through traditional local foods, in northern Iran. Iran J Public Health. 2006;35:57-63.

Salahi MA. Epidemiology of human fascioliasis in Iran. J Arch Military Med. 1(1): 6-12. 2009

Martínez-Barbabosa I, Gutiérrez-Quiroz M, Romero-Cabello R et al. Seroepidemiology of fascioliasis in school children in Mexico City. Rev Biomed. 2006;17

Turhan O, Korkmaz M, Saba R et al. Seroepidemiology of fascioliasis in the Antalya region and uselessness of eosinophil count as a surrogate marker and portable ultrasonography for epi-demiological surveillance. Le infezioni in medicina: rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive. 2006;14:208-212.

Esteban JG, González C, Bargues MD et al. High fascioliasis infection in children linked to a man‐made irrigation zone in Peru. Trop Med Int Health. 2002; 7(4):339-48.

IssueVol 12 No 3 (2017) QRcode
SectionOriginal Article(s)
Fasciolosis Seroepidemiology Freshwater plants Iran

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How to Cite
HEYDARIAN P, ASHRAFI K, MOHEBALI M, KIA EB, ARYAEIPOUR M, CHEGENI SHARAFI A, MOKHAYERI H, BOZORGOMID A, ROKNI MB. Seroprevalence of Human Fasciolosis in Lorestan Province, Western Iran, in 2015-16. Iran J Parasitol. 2017;12(3):389-397.