Iranian Journal of Parasitology 2016. 11(1):1-9.

One Health Approach Prospect for Integrated Control and Elim¬ination of Visceral Leishmaniasis in Ethiopia: A Narrative Re¬view Article
Tadesse HAILU


Background: Leishmaniasis is an obligate intercellular protozoon that affects animals and human. It has zoonosis and/or anthroponosis transmission. Human and veterinary medicine, environmental science and wildlife conservation special­ists have many commonalities in case of visceral leishmaniasis. Still the above disciplines respond against leishmaniasis in a separate way.   The aim of this re­view is to indicate inter- and intra- sectoral collaboration for planning future con­trol strategies.

Methods: literatures written on visceral leishmaniasis and one health approach were systematically reviewed from the year 1969 to 2014 from Pub Med, Scopus, Medline and Google scholar sources.

Result: Such a one health approach would enhance biomedical progress; im­prove medical and veterinary serves, entomological control and wildlife conser­vation for Visceral Leishmaniasis especially in endemic areas.

Conclusion: Inter- and intra – sectoral collaboration in the leishmaniasis con­trol is limited in Ethiopia. Therefore, incorporating one health approach or inte­grated inter- and intra – sectoral collaboration for visceral leishmaniasis control is an effective control strategy in endemic areas.


Visceral leishmaniasis; one health approach; Ethiopia; prevention; Integrated control strategy

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Alvar J, Vélez ID, Bern C, Herrero M, Desjeux P, Cano J, Jannin J, den Boer M; WHO Leishmaniasis Control Team. Leishmaniasis worldwide and global estimates of its incidence. PLoS One. 2012; 7(5):e35671.

WHO. Leishmaniasis, Fact sheet Nu375. 2013; Available: mediacen¬tre/factsheets/fs375/en/. Accessed 6 August 2014.

Desjeux P. Leishmaniasis: current situation and new perspectives. Comp Immunol Microbiol Infect Dis. 2004; 27:305–318.

Alvar J, Aparicio P, Aseffa A, Boer MD, Ca¬ñavate C, Dedet J-P, Gradoni L, Horst RT, López-Vélez R, Moreno J. The relationship be¬tween leishmaniasis and AIDS: the second 10 years. Clin Microbiol Rev. 2008; 21:334–359.

Chappuis F, Sundar S, Hailu A, Ghalib Hashim Rijal, Suman, Rosanna PW, Alvar J, Boelaert M. Visceral leishmaniasis: what are the needs for diagnosis, treatment and control? Nat Rev Microbiol. 2007; 5(11):873-82.

Zavitsanou A, Koutis C, Babatsikou F. Leish¬maniasis: an overlooked public health concern. Health Sci J. 2008; 2:196-205.

Dawit G,Girma Z, Simenew K.. A Review on Biology, Epidemiology and Public Health Sig¬nificance of Leishmaniasis. Acta Parasitol Glob. 2012; (3):43-53.

Ibrahim ME, Lambson B, Yousif AO, Deifalla NS, Alnaiem DA, Ismail A, Yousif H, Ghalib HW, Khalil EA, Kadaro A, Barker DC, El Hassan AM. Kala-azar in a high transmission focus: an ethnic and geographic dimension. Am J Trop Med Hyg. 1999; 61:941–944.

Tesh RB. Control of zoonotic visceral leish¬maniasis: is it time to change strategies? Am J Trop Med Hyg. 1995; 52:287-292.

Alvar J, Yactayo S, Bern C. Leishmaniasis and poverty. Trends Parasitol. 2006; 22: 552–57.

Cardenas R, Sandoval CM, Rodriguez-Morales AJ, Vivas P. Zoonoses and climate variability. Ann N Y Acad Sci. 2008; 1149:326–330.

Leta S, Dao THT, Mesele F, Alemayehu G. Visceral Leishmaniasis in Ethiopia: An Evolv¬ing Disease. PLoS Negl Trop Dis. 2014; 8(9):e3131.

Singh N, Mishra J, Singh R, Singh S. Animal Reservoirs of Visceral Leishmaniasis in India J Parasitol. 3013; 99(1):64-67.


MOH. National master plan for neglected tropical diseases (NTDS) (2013-2015), Addis Ababa, Ethiopia; 20013. www.ntdenvision .org/.../national_ntd_master_plan_ethiopia_2013

Daszak, P, Cunningham AA, Hyatt AD. Emerging infectious diseases of wildlife threats to biodiversity and human health. Science. 2000; 287:443-449.

Thompson RCA, Kutz SJ, Smith A. Parasite Zoonoses and Wildlife: Emerging Issues. Int J Environ Res Public Health. 2009; 6:678-693.

Hoogstraal H, Heyeneman D. Leishmaniasis in the Sudan republic: 30. Final report. Am J Trop Med Hyg. 1.969; 18:1091-1210.

Ashford R, Bray MA, Hutchinson M, Bray R. The Epidemiology of Cutaneous Leishmaniasis in Ethiopia. Trans Roy Soc Trop Med Hyg. 1973; 67:568–601.

Lainson R, Shaw JJ, Silveira FT, Braga RR. American visceral leishmaniasis: on the origin of Leishmania chagasi. Trans Roy Soc Trop Med Hyg. 1987; 81:517.

Roque ALR, Jansen AM. Wild and synan-thropic reservoirs of Leishmania species. Ameri¬cas International Journal for Parasitology: Para¬sites and Wildlife. 2014; 3:251–262.

Anderson RM, May RM. Infectious Diseases of Humans: Dynamics and Control. Oxford, UK: Oxford University Press; 1991. P. 768

Mersha C, Tewodros F. One Health One Med¬icine One World: Co-joint of Animal and Hu¬man Medicine with Perspectives, A review. Vet World. 2012; 5(4):238-243.

Mutinga MJ, Kihara SM, Lohding A, Mutero CM, Ngatia TA, Karanu F. Leishmaniasis in Kenya: description of leishmaniasis of a do¬mestic goat from Transmara, Narok District, Kenya. Trop Med Parasitol. 1989; 40(2):91-96.

Coura-Vital W, Reis AB, Reis LE, Braga SL, Roatt BM, Aguiar-Soares RD, Marques MJ, Veloso VM, Carneiro M. Canine visceral leishmaniasis: incidence and risk factors for in¬fection in a cohort study in Brazil. Vet Parasi¬tol. 2013; 197(3-4):411-417.

Dereure J, El-Safi SH, Bucheton B, Boni M, Kheir MM, Davoust B, Pratlong F, Feugier E, Lambert M, Dessein A, Dedet JP. Visceral leishmaniasis in eastern Sudan: parasite identifi¬cation in humans and dogs; host-parasite rela¬tionships. Microbes Infect. 2003; 5(12):1103-1108.

Sixl W, Sebek F, Reinthaler F, Mascher F. In¬vestigations of wild animals as Leishmania res¬ervoir in south Sudan. J Hyg Epid Microb Immun. 1987; 31:483-485

Kenubih A, Dagnachew S, Almaw G, Abebe T, Takele Y, Hailu A, Lemma W. A prelimi¬nary survey of domestic animal visceral leish¬maniasis and risk factors in North West Ethio¬pia. Trop Med Int Health. 2015 Feb;20(2):205-10.

CDC. Parasites - Leishmaniasis. Centers for Disease Control and Prevention. 2013; Availa¬ble: Accessed 2 January 2015.

Seblova V, Volfova V, Dvorak V, Pruzinova K, Votyapka J, Kassahun A, Gebre-Michael T, Hailu A, Warburg A, Volf P. Phlebotomus oriental¬is sandflies from two geographically distant Ethiopian localities: biology, genetic analyses and susceptibility to Leishmania donovani. PLoS Negl Trop Dis. 2013; 7:e2187.

Gebre-Michael T, Balkew M, Berhe N, Hailu A, Mekonnen Y. Further studies on the phlebotominesandflies of the kala-azar endem¬ic lowlands of Humera- Metema (North-West Ethiopia) with observations on their natural blood meal sources. Parasit Vectors. 2010; 3:6.

Soulsby EJL. Helminthes, arthropods and pro¬tozoa of domesticated animals. 7th ed. Phila¬delphia. Pa: USA; 1982.

Sutherst RW. Global Change and Human Vul¬nerability to Vector-Borne Diseases. Clinical microbiology reviews. 2004; 17(1):136-173.

Chappuis F, Sundar S, Hailu A, Ghalib H, Rijal S, Peeling RW, Alvar J, Boelaert M. Visceral leishmaniasis: What are the needs for diagnosis, treatment and control? Nat Rev Microbiol. 2007; 5: 873-882.

Mauricio IL, Stothard JR, Miles MA. The strange case of Leishmania chagasi. Parasitol. To¬day. 2000; 16:188–189

Anema A, Ritmeijer K. Treating HIV/AIDS and leishmaniasis co-infection in Ethiopia. CMAJ. 2005, 172:1434-1435.

Tsegaw T, Gadisa E, Seid A, Abera A, Teshome A, Mulugeta A, Herrero M, Argaw D, Jorge A, Aseffa A. Identification of envi¬ronmental parameters and risk mapping of vis¬ceral leishmaniasis in Ethiopia by using geo¬graphical information systems and a statistical approach. Geospat Health. 2013; 7:299-308.

Deribe K, Meribo K, Gebre T, Hailu A, Ali A, Aseffa A, Davey G. The burden of neglected tropical diseases in Ethiopia, and opportunities for integrated control and elimination. Parasit Vectors. 2012; 5:240.

Tekle A, Neri D, Debessai A. Kalaazar in Hu¬mera (north-west Ethiopia). Parassitologia. 1970; 72:21-25.

Ali A, Ashford RW. Viseral leishmaniasis in Ethiopia. IV. Prevalence, incidence and relation of infection to disease in an endemic area. Ann Trop Med Parasitol. 1994; 88:289–293.

Alvar J, Bashaye S, Daneil A, Cruz I, Aparicio P, Askal K, Orfanos G, Parreno F, Babaniyi O, Niggussu G, Cariavate K, Bern C. Kala azar outbreak in Libo Kemkem, Ethiopia: epidemi¬ological and parasitological assessment. Am J trop med Hyg. 2007; 77(2):275–282.

Tsegaw T, Gadisa E, Seid A, Abera A, Teshome A, Mulugeta A, Herrero M, Argaw D, Jorge A, Aseffa A. Identification of envi¬ronmental parameters and risk mapping of vis¬ceral leishmaniasis in Ethiopia by using geo¬graphical information systems and a statistical approach. Geospat Health, 2013; 7(2):299-308.

Gadisa E, Tsegaw T, Abera A, Elnaiem D-e, Boer M-d, Aseffa A, Jorge A. Eco-epidemiology of visceral leishmaniasis in Ethi¬opia. Parasites & Vectors. 2015; 8:381.

Lodge R, Diallo TO, Descoteaux A. Leishmania donovani lipophosphoglycan blocks NADPH oxidase assembly at the phagosome membrane. Cell. Microbiol. 2006; 8:1922–1931.

WHO. Leishmaniasis. Fact sheet; (2014).

WHO. Post-Kala-azar Dermal Leishmaniasis: A manual for case management and control. Report of a WHO consultative meeting, Kol¬kata, India; 2012.

Mengesha B, Abuhoy M. Kala-azar among labour immigrants in the Metema-Humera re¬gion of Ethiopia. Trop Geogr Med. 1978; 30:199–206.

Argaw D, Mulugeta A, Herrero M, Nombela N, Teklu T, et al. Risk factors for visceral Leishmaniasis among residents and migrants in Kafta-Humera, Ethiopia. PLoS Negl Trop Dis. 2013; 7:e2543.

Yimer M, Abera B, Mulu W, Zenebe Y, Bezabih B. Proportion of Visceral leishmaniasis and hu¬man immune deficiency virus co- infection among clinically confirmed visceral leishmania¬sis patients at the endemic foci of the Amhara National Regional State, north-west Ethiopia. A J Biomed Life Sci. 2014; 2(1):1-7.

Hurissa Z, Gebre-Silassie S, Hailu W, Tefera T, David GL, Cuevas LE. Hailu A. Clinical char¬acteristics and treatment outcome of patients with visceral leishmaniasis and HIV co-infection in northwest Ethiopia. Trop Med Int Health. 2010; 15:848–855.

Dawit G, Girma Z, Simenew K. A Review on Biology, Epidemiology and Public Health Sig¬nificance of Leishmaniasis. J Bacteriol Parasitol. 2013; 4: 166.

Maltezou CH. Visceral leishmaniasis: advances in treatment. Recent Pat Antiinfect Drug Dis¬cov. 2008; 3:192-198.

Yared S, Deribe K, Gebreselassie A, Lemma W, Akililu E, Kirstein OD, Balkew M, Warburg A, Gebre-Michael T Hailu A. Risk factors of visceral leishmaniasis: a case control study in north-western Ethiopia. Para¬sit Vectors. 2014; 7:470.

Singh S. New developments in diagnosis of leishmaniasis. Indian J Med Res. 2006; 123:311-330.

Sundar S, Pai K, Kumar R, Pathak-Tripathi K, Gam AA, Ray M, Kenney R. Resistance to treatment in Kala-azar: speciation of isolates from northeast India. Am J Trop Med Hyg. 2001; 65:193-196.

Mohebali M, Edrissian Gh H, Nadim A, Haj¬jaran H, Akhoundi B, Hooshmand B. Applica¬tion of direct agglutination test (DAT) for the diagnosis and sero-epidemiological studies of visceral leishmaniasis in Iran. Iran J Parasitol. 2006; 1:15-25.

Mohebali M, Edrissian GhH, Shirzadi MR, Hosseingholizadeh Gh, Pashaei MH, Ganji A, Zarei Z, Kousha A, Akhoundi B, Hajjaran H, Malekafzali H. Integrated visceral leishmaniasis surveillance system in primary care for children in Meshkin-Shahr district,north-western Islam¬ic Republic of Iran. East Mediterr Health J. 2010; 16(10):1050-1054

Herwaldt BL. Harrison’s Principles of Internal Medicine. 16th ed. Leishmaniasis; 2005. P. 1233-1238.

Palatnik-de-Sousa CB, Day MJ. One Health: The global challenge of epidemic and endemic leishmaniasis. Parasites & Vectors. 2011; 4:197.

WHO. Dramatic Upsurge in Visceral Leish¬maniasis Cases in the Horn of Africa, Press re¬lease. 1998; Available:


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