Iranian Journal of Parasitology 2014. 9(2):181-187.

Seroprevalence of Toxoplasma gondii Infections in Pregnant Women in Gorgan City, Golestan Province, Northern Iran-2012.
Mitra Sharbatkhori, Yusef Dadi Moghaddam, Abdol Sattar Pagheh, Rasool Mohammadi, Haleh Hedayat Mofidi, Saeedeh Shojaee


Background: Toxoplasma gondii is one of the most prevalent parasites of human and warm- blooded animals. Toxoplasmosis is important especially in two groups: pregnant women and immunocompromised patients. If women acquire the primary infection during the pregnancy, it would be life threatening or re-mains severe disorders for the fetus. This study was performed to evaluate the seroprevalence of T. gondii infection in pregnant women referred to Health Cen-ter in Gorgan City, Golestan Province, northern Iran.

Methods: Serum samples were collected from pregnant women referred to Health Center in Gorgan City, south eastern Caspian Sea. Anti- Toxoplasma IgG and IgM antibodies were determined by commercially ELISA kits and the rela-tion of infection with socio-demographic and risk factors such as age, education, occupation, cat ownership, soil contact and some other factors was studied.

Results: From 555 tested sera of pregnant women referred to Health Center in Gorgan, 39.8% had IgG antibodies against T. gondii and 3.4% were positive for IgM antibodies. A significant correlation was seen between T. gondii infection with age and soil contact.

Conclusion: About 60% of pregnant women in Gorgan City are seronegative against T. gondii, so they should considered as at risk persons.


ELISA; Iran; Pregnant women; Prevalence; Toxoplasma gondii

Full Text:



Boyle JP, Radke JR. A history of studies that examine the interactions of Toxoplasma with its host cell: Emphasis on in vitro models. Int J Parasitol. 2009; 39(8):903-14.

Montoya J, Liesenfeld O. Toxoplasmosis. Lan-cet. 2004; 363(9425):1965-76.

Weiss LM, Dubey JP. Toxoplasmosis: A his-tory of clinical observations. Int J Parasitol. 2009; 39(8):895-901.

Dubey JP. The History of Toxoplasma gondii-The First 100 Years. 2008; 55(467-75.

Remington JS, Thulliez P, Montoya JG. Recent Developments for Diagnosis of Toxoplasmo-sis. Journal of Clinical Microbiology. 2004; 42(3):941-5.

Dubey J, Beattie C, Toxoplasmosis of animals and man. Boca Raton, Florida CRC Press; 1988.

Tenter AM, Heckeroth AR, Weiss LM. Toxo-plasma gondii: from animals to humans. Int J Parasitol. 2000; 30(12-13):1217-58.

Speer CA, Dubey JP. Ultrastructural differenti-ation of Toxoplasma gondii schizonts (types B to E) and gamonts in the intestines of cats fed bradyzoites. Int J Parasitol. 2005; 35(2):193-206.

Reis MM, Tessaro MM, D'azevedo PA. Perfil sorológico para toxoplasmose em gestantes de um hospital público de Porto Alegre. Rev Bras Ginecol Obstet. 2006; 28(3):158-64.

Mostafavi SN, Jalali Monfared L. Toxoplasmo-sis Epidemiology in Iran: A Systematic Review. Journal of Isfahan Medical School. 2012; 30(176):1-15.

Remington J, McLeod R, Thulliez PH, Desmonts G, Infectious diseases of the fetus and newborn infant in Toxoplasmosis, J Re-mington, Klein, J, Wilson, C, Baker, C, Editors., Elsevier Saunders Philadelphia, 2006.

Oyibo Wellington A, Oladosu Oladipo O, Agomo Chimere O, Ojuromi Oladele T, Anunobi C, C. , Soyebi K. Congenital Toxo-plasmosis A Review of its Pathology, Immune Response and current treatment options. Sier-ra Leone J Biomed Res. 2009; 1(1):2-20.

Al-Mohammad H, Balaha M, Al-Moghannum M. Toxoplasmosis among the pregnant wom-en attending a Saudi maternity hospital: sero-prevalence and possible risk factors. Ann Trop Med Parasitol. 2010; 104(6):493-504.

Fuente M, Bovone N, Cabral G. Profilaxis de la toxoplasmosis prenatal. Medicina (Buenos Aires) 1997; 57(155-60.

Aspِ ck H, Pollak A. Prevention of pre natal toxoplasmosis by serological screening of preg-nant women in Austria. Scandinavian J Infe Dis. 1992; S82(32-8.

Jaqueti J, Hernandez-Garcia R, Nicolas D, Martinez-Hernandez D, Navarro-Gallar F, Garcia-Esteban RJ. Serology against Toxoplasma gondii in pregnant women. Development of prevalence rates in the course of 4 years (In Spanish). Rev Clín Esp. 1991:278-80.

Studenicová C, Ondriska F, Holková R. Sero-prevalence of Toxoplasma gondii among pregnant women in Slovakia (In Slovak). Epidemiol Mikrobiol Imunol. 2008; 57(1):8-13.

Akyar I. Seroprevalence and coinfections of Toxoplasma gondii in childbearing age women in Turkey. Iranian J Publ Health. 2011; 40(1):63-7.

Ayi I, Edu SAA, Apea-Kubi KA, Boamah D, Bosompem KM, Edoh D. Seroepidemiology of toxoplasmosis amongst pregnant in the greater ACCRA region of Ghana. Ghana Med-ical Journal. 2009; 43(3):107-14.

Ishaku B, Ajogi I, Umoh JU, Lawal I, Randawa AJ. Seroprevalence and risk factors for Toxo-plasma gondii infection among antenatal women in Zaria, Nigeria. Research J Med and Medical Sci. 2009; 4(2):483-8.

Alvarado-Esquivel C, Torres-Castorena A, Liesenfeld O, Garcı´a-Lo´ pez CR, Estrada-Martı´nez S, Sifuentes-A´lvarez V, Marsal-Herna´ ndez JF, Esquivel-Cruz R, Sandoval-Herrera F, Castan˜ eda JA, Dubey JP. Seroepi-demiology of Toxoplasma gondii infection in pregnant women in rural Durango, Mexico. J Parasitol. 2009; 95(2):271-4.

Athari D. Sero prevalence of Toxoplasma anti-bodies among pregnant women in Kerman-shah. Med J Islamic Rep Ir. 1993:93-6.

Cheraghipour K, HA. T, Falah M, Sheykhian A, Sardarian K, Rostamnezhad M, Maghsoudi A. Seroprevalence of toxoplasmosis in pregnant women admitted to the health centers of Khorram-Abad city, Iran (In Persian). Scientific Journal of Hamadan University of Medical Sci-ences and Health Services. 2010; 17(3 (SN 57)):51-46.

Jalayer T, Alame T. Seroprevalence of congeni-tal toxoplasmosis in neonatal born in Isfahan. Second congress of parasitology in Tehran (Iran). . 1997:23.

Moalaee H, Shirzad E, Namazi M. Seroepide-miology of toxoplasmosis and its eye complica-tion in pregnant women. Sabzavar University Med Sci J (Iran). 1992:21-3.

Abdi J, Shojaee S, Mirzaee A, Keshavarz H. Seroprevalence of Toxoplasmosis in Pregnant Women in Ilam Province, Iran. Iranian J Para-sitol. 2008; 3(2):34-7.

Keshavarz H, Mamishi S, Daneshvar H. The prevalence of Toxoplasma infection in hospital-ized patients in selected hospitals of Kerman (in Persian). J Med Sci Kerman. 2000; 7(3):129-36.

Hajsoleimani F, Ataeian A, Nourian A, Mazloomzadeh S. Seroprevalence of Toxo-plasma gondii in pregnant women and bioassay of IgM positive cases in Zanjan, Northwest of Iran. Iranian J Parasitol. 2012; 6(2):82-6.

Ghorbani M, Edrisian G, Assad N. Serological survey of toxoplasmosis in northern of Iran. Trans R Soc Trop Med Hyg. 1978; 72(369-71.

Saffar M, Ajami A, Moslemi zadeh N. Preva-lence of Toxoplasma gondi in pregnancy in Sari 1997-1998 (in Persian). Journal of Mazandaran University of Medical Sciences 1999; 9(24):1-5.

Saeedi M, Veghari GR, Marjani A. Seroepide-miologic Evaluation of Anti-Toxoplasma Anti-bodies among Women in North of Iran. Pak J Bio Sci. 2007; 10(14):2359-62.

Setoodeh Jahromi A, Safa O, Zare S, Davoodi-an P, Farshid Far GR. Prevalence of Toxo-plasma antibodies in pregnant women referred to Shariati Hospital, Bandar Abbas, Iran, 1999-2000 (in Persian). Journal of Hormozgan Uni-versity of Medical Sciences 2003; 4(6):25-30.

Kamyabi Z, Atapour M. Investigation of the prevalence of Toxoplasma antibodies in women during marriage consultation in Kerman city (in Persian). J Med Sci Kerman. 1999; 6(3):127-33.

Fallah M, Rabiee S, Matini M, Taherkhani H. Seroepidemiology of toxoplasmosis in primi-gravida women in Hamadan, Islamic Republic

of Iran, 2004. East Mediterr Health J. 2008; 14(1):163-71.

Cheraghipour K, Sheykhian A, Maghsoudi A, Hejazi Z, Rostamnezhad M. Seroprevalence study of toxoplasmosis in pregnant women re-ferred to Aleshtar rural and urban health cen-ters in 2008. Yafteh. 2009; 11(3):65-74.

Sharifi -Mood B, Hashemi-Shahri M, Salehi M, Naderi M, Naser-poor T. Seroepidemiology of Toxoplasma Infection in the Pregnant Women in Zahedan, Southeast of Iran. J Res Health Sci. 2004; 4(1):1-3.

Parvizpour F, Hajighasemlo S, Hasani S, Olfati L, Bahmani A, Hoseini F, Gharibi F. Toxoplas-mosis infection in the pregnant women in the first half of pregnancy, in Kamyaran in 2008 (in Persain). Scientific Journal of Kurdistan Uni-versity of Medical Sciences. 2008; 15(1):72-8.


  • There are currently no refbacks.

Creative Commons Attribution-NonCommercial 3.0

This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.