Prevalence of Toxoplasma gondii among Iranian Blood Donors: A Narrative Review Article
Abstract
Background: Toxoplasmosis is a common parasitic disease. There is likelihood of exposure to Toxoplasma gondii in blood donors during the periods of life. Currently, laboratory screening of blood donors for T. gondii is not routinely available. The objectives of this review were to study the effects of T. gondii on blood safety and to approach for risk reduction in blood recipients.
Methods: A literature search was performed using Cochrane library, PubMed, Scopus, Google scholar IranMedex, SID and Magiran without time limitation. All studies, which had reported the prevalence of T. gondii in Iranian blood donors in both English and Farsi languages, were evaluated and reviewed. The contents of the transfusion medicine text books related to this issue were reviewed. Searching keywords were "Blood Donors" or "Blood Transfusion" and "Toxoplasma" or "Toxoplasmosis" and Iran.
Results: In order to study the prevalence of T. gondii in Iranian blood donors, six studies have been reviewed. IgG and IgM antibodies varied between 12.3% to 52.8% and 0% to 5.47%. Some of these studies have suggested to doing the screening for all blood donors. However, based on parasitological and epidemiological evidences, there is little chance for parasite transmission by blood transfusion.
Conclusion: By considering the moderate prevalence, difficulty in the differentiation between recent and past infections, and cost-effectiveness, it is not possible and rational to perform screening of donated blood. To reduce the risk of parasite transmission, leukofilteration method is recommended.
Karimi G, Gharehbaghian A, Fallah Tafti M, Vafaiyan V. Emerging Infectious Threats to the Blood Supply: Seroepidemiological Studies in Iran-a Review. Transfus Med Hemother. 2013; 40(3):210-17.
Karimi G, Samiei S, Hatami H, Gharehbaghian A, Vafaiyan V, Namini MT. Detection of Chlamydia pneumoniae in peripheral blood mon¬onuclear cells of healthy blood donors in Teh¬ran Regional Educational Blood Transfusion Centre. Transfus Med. 2010; 20(4):237-43.
Ferdowsi S, Farsi L, Tajalli SM, Soltani H. Se¬roprevalence Anti-Toxoplasma gondii antibodies and Anti- Epstein-Barr virus (EBV) Antibody among volunteer blood donors Referred Gonabad Blood Transfusion. Journal of Zabol University of Medical Sciences and Health Services. 2013; 5(2): 60-9.
Modrek MJ, Mousavi M, Saravani R. Toxo-plasma gondii Seroprevalence Among Blood Donors in Zahedan, Southeastern Iran. Int J Infect. 2014; 2(1): e21111.
Sarkari B, Shafiei R, Zare M, Sohrabpour S, Kasraian L. Seroprevalence and molecular di¬agnosis of Toxoplasma gondii infection among blood donors in southern Iran. J Infect Dev Ctries. 2014; 8(4):543-47.
Ormazdi H, Sanikhani N, Hadighi R, Akhlaghi L, Memar A, Razmju E. investigation of anti¬bodies (IgM and IgG) against Toxoplasma gondii in blood donors referred to Tehran blood transfusion organization by ELISA. Urmia Medical Journal. 2010; 21(2): 212-16.
Shaddel M, Mirzaii DI, Hoshangi M. anti-Toxoplasma gondii antibody levels in blood supply of Shiraz blood transfusion institute, iran. Iran J Parasitol. 2014; 9(1):120-24.
Zainodini, N, Zare-Bidaki, M, Abdollahi S, Afrooz M, Ziaali N, Ebrahimian M, Kazemi Arababadi M. Molecular and Serological De¬tection of Acute and Latent Toxoplasmosis Using Real-Time PCR and ELISA Techniques in Blood Donors of Rafsanjan City, Iran. Iran J Parasitol. 2014; 9(3):336-41.
Hill D, Dubey JP. Toxoplasma gondii: transmis¬sion, diagnosis and prevention. Clin Microbiol Infect. 2002; 8(10):634-40.
Dubey JP. The history of Toxoplasma gondii - the first 100 years. J Eukaryot Microbiol. 2008; 55(6):467-75.
Spencer BR. Transfusion transmission of para¬sites. In: simon TL, editors. Rossi's Principles of Transfusion Medicine. UK: Blackwell Pub¬lishing Ltd; 2009. P. 760- 72.
David A. Leiby, Silvano wendel. The protozo¬an parasites. In: John A. J. Barbara, Fiona A. M. Regan, Marcela Contreras, eds. Transfusion Microbiology. 1st ed. UK: Cambridge Univer¬sity Press; 2008: 117–39.
Pappas G, Roussos N, Falagas ME. Toxo-plasmosis snapshots: Global status of Toxo¬plasma gondii seroprevalence and implications for pregnancy and congenital toxoplasmosis. Int J Parasitol. 2009; 39(12):1385-94.
Robert-Gangneux F, Darde M-L. Epidemiolo¬gy of and diagnostic strategies for toxoplasmo¬sis. Clin Microbiol Rev. 2012; 25(2):264-96.
Mostafavi SN, Jalali Monfared L. Toxoplasmo¬sis epidemiology in Iran: a systematic review. J Isfahan Med School.2012; 30(176): 1-15.
Daryani A, Sarvi S, Aarabi M, Mizani A, Ah¬madpour E, Shokri A, et al. Seroprevalence of Toxoplasma gondii in the Iranian General Popula¬tion: A Systematic Review and Meta-analysis. Acta Tropica. 2014; 137: 185–194.
Mary L Turgeon. Toxoplasmosis. In: immu¬nology & serology in laboratory medicine. 5th ed. Mosby; 2013: 264 –269.
Wilson M, Remington JS, Clavet C, Varney G, Press C, Ware D. Evaluation of six commercial kits for detection of human immunoglobulin M antibodies to Toxoplasma gondii. J Clin Micro¬biol.1997; 35(12): 3112–15.
Montoya JG, Liesenfeld O. Toxoplasmosis. Lancet. Lancet. 2004; 363(9425):1965-76.
José G. Montoya, John C. Boothroyd, Joseph A. Kovacs. Toxoplasma gondii. In: Bennett, Raphael Dolin, Martin J. Blaser, editors. Princi¬ples and Practice of Infectious Diseases. Phila¬delphia: Elsevier; 2015. P. 3122–53.
Ivovic V, Vujanic M, Zivkovic T, Klun I, Djurkovic-Djakovic O. Molecular Detection and Genotyping of Toxoplasma gondii from Clinical Samples. In: toxoplasmosis recent ad¬vances.1st ed. Croatia: InTech; 2012: 103–120.
Montoya JG. Laboratory diagnosis of Toxo¬plasma gondii infection and toxoplasmosis. J In¬fect Dis. 2002; 185 Suppl 1:S73-82.
John AJ, Barbara RE. Introduction: Transfu¬sion Transmitted Infections, Then and Now. In: In: John A. J. Barbara, Fiona A. M. Regan, Marcela Contreras, eds. Transfusion Microbi¬ology. 1st ed. UK: Cambridge University Press; 2008: 1-7.
Karimi G, Mardani A, Zadsar M. Toxoplasma and Blood Transfusion. Iran J Parasitol. 2014; 9(4): 597-98.
Sheridan GEC, Masters CI, Shallcross JA, Mackey BM. Detection of mRNA by Reverse Transcription-PCR as an indicator of viability in Escherichia coli cells. Appl Environ Microbiol. 1998; 64(4): 1313–1318.
Sundar P, Mahadevan A, Jayshree RS, Sub-bakrishna DK, Shankar SK. Toxoplasma sero¬prevalence in healthy voluntary blood donors from urban Karnataka. Indian J Med Res. 2007; 126(1):50-5.
Elhence P, Agarwal P, Prasad KN, Chaudhary RK. Seroprevalence of Toxoplasma gondii anti¬bodies in North Indian blood donors: Implica¬tions for transfusion transmissible toxoplasmo¬sis. Transfus Apher Sci. 2010; 43(1):37-40.
Nissapatorn V, Kamarulzaman A, Init I, Tan LH, Rohela M, Norliza A, Chan LL, Latt HM, Anuar AK, Quek KF. Seroepidemiology of toxoplasmosis among HIV-infected patients and healthy blood donors. Med J Malaysia. 2002; 57(3):304-10.
Mahmood SH, Al-Qadhi BN, Zghair KH. Prevalence of Toxoplasmosis of Males Blood Donors in Baghdad. Iraqi J Sci. 2013; 54(4): 832-41.
Alvarado-Esquivel C, Mercado-Suarez MF, Rodri guez-Briones A et al. Seroepidemiology of infection with Toxoplasma gondii in healthy blood donors of Durango, Mexico. BMC In¬fect Dis. 2007;7(1):75.
Colho RAL, Kobayashi M, Carvalho Jr LB. Prevalence of IgG antibodies specific to Toxo¬plasma gondii among blood donors in Recife, Northeast Brazil. Rev Inst Med Trop Sao Pau¬lo. 2003; 45(4):229-31.
Elsheikha HM, Azab MS, Abousamra NK, Rahbar MH, Elghannam DM, Raafat D. Sero¬prevalence of and risk factors for Toxoplasma gondii antibodies among asymptomatic blood donors in Egypt. Parasitol Res. 2009; 104(6):1471-6.
Zarkovic A, MacMurray C, Deva N, Ghosh S, Whitley D, Guest S. Seropositivity rates for Bartonella henselae, Toxocara canis and Toxoplasma gondii in New Zealand blood donors. Clin Exp Oph-thalmol. 2007; 35(2):131-4.
Chiang TY, Hsieh HH, Kuo MC, Chiu KT, Lin WC, Fan CK, Fang CT, Ji DD. Seroepi¬demiology of Toxoplasma gondii infection among healthy blood donors in Taiwan. PloS One. 2012;7(10):e48139.
Yazar S, Eser B, Yay M. Prevalence of anti-Toxoplasma gondii antibodies in Turkish blood donors. Ethiop Med J. 2006 Jul;44(3):257-61.
Al-Amari OM. Prevalence of antibodies to Toxoplasma gondii among blood donors in Abha, Asir Region, southwestern Saudi Arabia. J Egypt Public Health Assoc. 1994; 69(1-2):77-88.
Svobodova V, Literak I. Prevalence of IgM and IgG antibodies to Toxoplasma gondii in blood donors in the Czech Republic. Eur J Epidemiol. 1998; 14(8):803-5.
Pinlaor S, Ieamviteevanich K, Pinlaor P, Ma¬leewong W, Pipitgool V. Seroprevalence of specific total immunoglobulin (Ig), IgG and IgM antibodies to Toxoplasma gondii in blood donors from Loei Province, Northeast Thai¬land. Southeast Asian J Trop Med Public Health. 2000; 31(1):123-7.
Yomtovian R, Gernsheimer T, Assmann SF, Mohandas K, Lee TH, Kalish LA, Busch MP. WBC reduction in RBC concentrates by pres¬torage filtration: multicenter experience. Trans¬fusion. 2001; 41(8):1030-36.
Roger Y. Dodd, Susan L. Stramer. Transfu¬sion-transmitted infections. In: Michael F. Murphy, Derwood H. Pamphilon, Nancy M. Heddle. Practical Transfusion Med. 2009. P. 141.
Leiby D.A, Wendel S. The protozoan parasites. In: John A. J. Barbara J.A.j, editors. Transfu¬sion Microbiology. UK: Cambridge University Press; 2008. P. 117-139.
Infectious agents transmitted by transfusion. In: Harvey G. Klein, David J. Anstee. Molli¬son's Blood Transfusion in Clinical Medicine. Blackwell publishing. 2005. P. 746-747.
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| Issue | Vol 11 No 1 (2016) | |
| Section | Review Article(s) | |
| Keywords | ||
| Blood Donors Blood Transfusion Toxoplasmosis Toxoplasma gondii Iran | ||
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