Causes of Pediatric Visceral Leishmaniasis in Southeastern Iran
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Abstract
Leishmania infantum is the most frequent cause of visceral leishmaniasis and L. tropica has been rarely linked to the disease in Iran. In this study, bone marrow aspirates were collected from 10 child patients, suspected with visceral leishmaniasis referred to the Pediatric Wards of Kerman Medical Hospitals, Kerman, Iran during 2002–2011. Leishmania species were identified by using nested PCR in all slides. The PCR samples from nine patients indicated L. infantum as principal causative agent of visceral leishmaniasis and one L. tropica as a minor species.
Minodier P, Piarroux R, Garnier JM, Unal D, Perrimond H, Dumon H. Pediatric visceral leishmaniasis in southern France. Pediatr Infect Dis J. 1998; 17(8):701-4.
Murray HW, Berman JD, Davies CR, Saravia NG. Advances in leishmaniasis. Lancet. 2005; 366(9496):1561–77.
Mahmoudvand M, Mohebali H, Sharifi I, Keshavarz H, Hajjaran H, Akhoundi B, Jahanbakhsh S, Zarean M, Javadi A. Epidemiological Aspects of Visceral Leishmaniasis in Baft District, Kerman Province, Southeast of Iran. Iran J Parasitol.2011; 6(1):1–11.
Hervás JA, Martín-Santiago A, Hervás D, Rojo E, Mena A, Rocamora V, Dueñas J. Old world Leishmania infantum cutaneous leishmaniasis unresponsive to liposomal amphotericin B treated with topical imiquimod. Pediatr Infect Dis J. 2012; 31(1):97-100.
Mohebali M. Visceral leishmaniasis in Iran: Review of the Epidemiological and Clinical Features. Iran J Parasitol.2013; 8(3):348-58.
Jafari S, Hajiabdolbaghi M, Mohebali M, Hajjaran H, Hashemian H. Disseminated leishmaniasis caused by Leishmania tropica in HIVpositive patients in the Islamic Republic of Iran. East Mediterr Health J. 2010; 16(3):340-3.
Kazemi Rad E, Mohebali M, Hajjaran H, Rezaei S, Mamishi S. Diagnosis and characterization of Leishmania species in Giemsa-stained slides by PCR-RFLP. Iran J Public Health.2008; 37: 54-60.
Noyes HA, Reyburn H, Bailey JW, Smith D. A nested-PCR-based schizodeme method for identifying Leishmania kinetoplast minicircle classes directly from clinical samples and its application to the study of the epidemiology of Leishmania tropica in Pakistan. J Clin Microbiol. 1998; 36(10):2877–81.
Hajjaran H, Mohebali M, Mamishi S, Vasigheh F, Oshaghi MA, Naddaf SR, Teimouri A, Edrissian GH, Zarei Z. Molecular identification and polymorphism determination of cutaneous and visceral leishmaniasis agents isolated from human and animal hosts in Iran. Biomed Res Int. published online Oct 28, 2013. doi: 10.1155/2013/789326.
Alborzi A, Rasouli M, Shamsizadeh A. Leishmania tropica-isolated patient with visceral leishmaniasis in southern Iran. Am J Trop Med Hyg.2006; 74(2):306–7.
Magill AJ, Grogl M, Gasser RA, Jr., Sun W, Oster CN. Visceral infection caused by Leishmania tropica in veterans of Operation Desert Storm. N Engl J Med. 1993; 328(19):1383–7.
Toz SO1, Culha G, Zeyrek FY, Ertabaklar H, Alkan MZ, Vardarlı AT, Gunduz C, Ozbel Y. A real-time ITS1-PCR based method in the diagnosis and species identification of Leishmania parasite from human and dog clinical samples in Turkey. PLoS Negl Tropm Dis. 2013;7(5):e2205. doi: 10.1371/journal.pntd. 0002205.
| Files | ||
| Issue | Vol 9 No 4 (2014) | |
| Section | Articles | |
| Keywords | ||
| Iran Leishmania tropica Visceral leishmaniasis | ||
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