Short Communication

A 20 Years Retrospective Descriptive Study of Human Cystic Echinococcosis and the Role of Albendazole Concurrent with Surgical Treatment: 2001-2021

Abstract

Background: Hydatid cyst, caused by the larvae of Echinococcus granulosus, is one of the most severe cestode infections occurring in Iran. The liver is the most commonly involved organ. The present study was carried out to review the demographic of 20 years surgically treated hydatic cysts.
Methods: Ninety-eight patients were enrolled in the study. Demographic features, time of surgery, cyst size, and albendazole usage have been reviewed from the medical records of patients in Loghman Hakim Hospital, Tehran, Iran, from 2001 to 2021. Statistical analysis was performed to find any correlation between the uses of concurrent albendazole with surgical procedure.
Results: Of 98 patients with hydatid cyst, 57 (58.2%) were female. The mean age of patients was 39.4 ± 18.7 yrs, and the mean surgery time was 217.5 ±   81.4 minutes. Regarding the infection site, the liver (60.2%) and lungs (22.4%) were the most affected organs, respectively. 56.1% of patients had one cyst, and 42.9 % had two or more cysts. 20.4% of them had taken albendazole before surgery, but 86.7 % took it after the operation. No recurrent cysts were seen among 91.8% of them, but 8.2% mentioned suffering from a recurrent cyst. 85.7% of those recurrent cases did not receive albendazole before surgery, and 75% of recurrent cases after surgery did not take albendazole (P<0.05).
Conclusion:  Administration of albendazole before and after the operation was significantly related to reduced recurrence, bleeding, morbidity, and even the time of surgery.

1. Kamali M, Yousefi F, Mohammadi MJ, et al. Hydatid cyst epidemiology in Khuzestan, Iran: a 15-year evaluation. Arch Clin Infect Dis. 2018; 13(1):e13765.
2. Parkoohi PI, Jahani M, Hosseinzadeh F, et al. Epidemiology and clinical features of hydatid cyst in Northern Iran from 2005 to 2015. Iran J Parasitol. 2018;13:310-316.
3. Arif SH, Wani NA, Zargar SA, et al. Albendazole as an adjuvant to the standard surgical management of hydatid cyst liver. Int J Surg. 2008;6:448-51.
4. Akhan O, Yildiz AE, Akinci D, et al. Is the adjuvant albendazole treatment really needed with PAIR in the management of liver hydatid cysts? A prospective, randomized trial with short-term follow-up results. Cardiovasc Intervent Radiol. 2014;37:1568-74.
5. Arif SH, Malik AA, Khaja AR, et al. Role of albendazole in the management of hydatid cyst liver. Saudi J Gastroenterol. 2011;17(5):343-347.
6. Yetim B, Kilic E. The role of combination pre-and postoperative albendazole therapy in the surgical management of liver hydatidosis. Ann Ital Chir. 2018;89:528-533.
7. Jerraya H, Khalfallah M, Osman SB, et ak. Predictive factors of recurrence after surgical treatment for liver hydatid cyst. Surg Endosc. 2015;29(1):86-93.
8. Keshmiri M, Baharvahdat H, Fattahi SH, et al. Albendazole versus placebo in treatment of echinococcosis. Trans R Soc Trop Med Hyg. 2001;95(2):190-4.
9. Gomez IGC, López-Andújar R, Belda Ibáñez T, et al. Review of the treatment of liver hydatid cysts. World J Gastroenterol. 2015;21(1):124-31.
10. WHO. The International Statistical Classification of Diseases and Health Related Problems ICD-10: Tenth Revision. Volume 1: Tabular List: World Health Organization; 2004.
11. Sozuer E, Akyuz M, Akbulut S. Open surgery for hepatic hydatid disease. Int Surg. 2014;99(6):764-769.
12. Peker KD, Gumusoglu AY, Seyit H, et al. Prevention of Postoperative Bile Leak in Partial Cystectomy for Hydatid Liver Disease: Tricks of the Trade. J Gastrointest Surg. 2015;19(12):2228-34.
13. Arabnejad F, Lashkarizadeh MR, Mohseni MM, et al. Epidemiology and Early Complications of Lung and Liver Hydatid Cyst Surgery among Patients Referred to Afzalipour Hospital, Kerman University of Medical Sciences During 2003-2013. Journal of Kerman University of Medical Sciences. 2016;23:543-53.
14. Ahmadi N, Hamidi M. A retrospective analysis of human cystic echinococcosis in Hamedan province, an endemic region of Iran. Ann Trop Med Parasitol. 2008;102(7):603-9.
15. Moosazadeh M, Abedi G, Mahdavi SA, et al. Epidemiological and clinical aspects of patients with hydatid cyst in Iran. J Parasit Dis. 2017;41(2):356-360.
16. Dehkordi AB, Sanei B, Yousefi M, et al. Albendazole and treatment of hydatid cyst: review of the literature. Infect Disord Drug Targets. 2019;19(2):101-104.
17. Rokni M. Echinococcosis/hydatidosis in Iran. Iranian J Parasitol. 2009. 4(2):1-16.
18. Ramos G, Antonio Orduña M, et al. Hydatid cyst of the lung: diagnosis and treatment. World J Surg. 2001; 25(1):46-57.
19. Mousavi S, Samsami M, Fallah M, et al. A retrospective survey of human hydatidosis based on hospital records during the period of 10 years. J Parasit Dis. 2012;36(1):7-9.
20. Montazeri V, Sokouti M, Rashidi MR. Comparison of pulmonary hydatid disease between children and adults. Tanaffos. 2007; 6(1), 13-18.
21. Eckert J, Gemmell M, Meslin Fo-X, et al. WHO/OIE manual on echinococcosis in humans and animals: a public health problem of global concern: Paris, France: World Organisation for Animal Health; 2001.
22. Marom G, Khoury T, Gazla SA, et al. Operative treatment of hepatic hydatid cysts: A single center experience. Asian J Surg. 2019;42:702-7.
23. Ahumada V, Moraga F, Rada G. Laparoscopy or open surgery for the treatment of hydatid cyst? Medwave. 2016;16 Suppl 1:e6385.
24. Bildik N, Çevik A, Altintas M, et al. Efficacy of preoperative albendazole use according to months in hydatid cyst of the liver. J Clin Gastroenterol. 2007;41(3):312-6.
25. Yüksel O, Akyürek N, Şahin T, et al. Efficacy of radical surgery in preventing early local recurrence and cavity-related complications in hydatic liver disease. J Gastrointest Surg. 2008;12(3):483-9.
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IssueVol 18 No 1 (2023) QRcode
SectionShort Communication(s)
DOI https://doi.org/10.18502/ijpa.v18i1.12386
Keywords
Echinococcosis Albendazole General Surgery Anthelmintics Antiparasitic Agents
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How to Cite
1.
Mahmoodi S, Ebrahimian M, Mirhashemi SH, Soori M, Rashnoo F, Oshidari B, Shadidi Asil R, Zamani A, Hajinasrollah E. A 20 Years Retrospective Descriptive Study of Human Cystic Echinococcosis and the Role of Albendazole Concurrent with Surgical Treatment: 2001-2021. Iran J Parasitol. 2023;18(1):100-106.