Original Article

Efficacy of Preoperative Albendazole on Protoscoleces Viability in Hydatid Cyst of the Liver

Abstract

Background: Optimal duration for medical therapy of liver hydatid cysts before surgery in not certainly defined yet. In this study, we aimed to evaluate the effectiveness of 2 weeks preoperative albendazole in decreasing viable cysts.

Methods: Patients referring to Imam Reza Hospital, Mashhad, Iran with a diagnosis of hepatic hydatid cyst were randomly divided into intervention (44 patients) and control (46 patients) groups. The case group were treated with oral albendazole before surgery and the control group underwent surgery without albendazole therapy. Efficacy of albendazole on the reduction of prevalence and viability of the protoscoleces was finally evaluated.

Results: A number of 90 patients were included in the final analysis. Protoscoleces were reported alive in 10 (22.7%) and 17 (36.9%) of patients in the case and control group, respectively. The decrease of live protoscoleces in case group was not statistically significant (P=0.14).

Conclusion: Decrease in the viability of protoscoleces in hepatic hydatid cysts after 2 weeks administration of oral albendazole at a dose of 10 mg/kg/day preoperatively, is not significant. Optimal duration of medical treatment before surgery seems to be 4 weeks or more.

1. Farazi A, Zarinfar N, Kayhani F, Khazaie F. Hydatid disease in the central region of Iran: A 5-year epidemiological and clinical overview. Cent Asian J Glob Health. 2019;8:364.
2. Deplazes P, Rinaldi L, Alvarez Rojas CA, et al. Global distribution of alveolar and cystic echinococcosis. Adv Parasitol. 2017;95:315-493.
3. Jenkins DJ, Romig T, Thompson RC. Emergence/re-emergence of Echinococcus spp.--a global update. Int J Parasitol. 2005;35:1205-1219.
4. Shafiei R, Teshnizi SH, Kalantar K, Gholami M, Mirzaee G, Mirzaee F. The seroprevalence of human cystic echinococcosis in Iran: A systematic review and meta-analysis study. J Parasitol Res. 2016;2016:1425147.
5. Wen H, Vuitton L, Tuxun T, Li J, Vuitton DA, Zhang W, McManus DP. Echinococcosis: Advances in the 21st century. Clin Microbiol Rev. 2019;32:e00075-00018.
6. Salamone G, Licari L, Randisi B, et al. Uncommon localizations of hydatid cyst. Review of the literature. G Chir. 2016;37:180-185.
7. Deák J, Zádori G, Csiszkó A, Damjanovich L, Szentkereszty Z. Hydatid disease of pancreas: A case report. Interv Med Appl Sci. 2019;11:74-76.
8. Jabbari Nooghabi A, Raofi K, Motie MR. Concomitant splenic and hepatic hydatidosis: Report of two cases and review of the literature. Acta Medica Iranica. 2015;53(1):74-7.
9. Noaman H, Rawaf S, Majeed A, Salmasi AM. Hydatid cyst of the heart. Angiology. 2017;68:765-768.
10. Arianpoor A, Motie MR, Telefoni MY, Amini E. Concurrent hydatidosis of the liver, spleen and breast: A case report. Arch Clin Infect Dis. 2018;13
11. Safioleas MC, Misiakos EP, Kouvaraki M, Stamatakos MK, Manti CP, Felekouras ES. Hydatid disease of the liver: A continuing surgical problem. Arch Surg. 2006;141:1101-1108.
12. Brunetti E, Kern P, Vuitton DA. Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans. Acta Trop. 2010;114:1-16.
13. Dehkordi AB, Sanei B, Yousefi M, et al. Albendazole and treatment of hydatid cyst: Review of the literature. Infect Disord Drug Targets. 2019;19:101-104.
14. Creţu CM, Codreanu RR, Mastalier B, et al. Albendazole associated to surgery or minimally invasive procedures for hydatid disease--how much and how long. Chirurgia (Bucur). 2012;107:15-21.
15. Shams Ul B, Arif SH, Malik AA, Khaja AR, Dass TA, Naikoo ZA. Role of albendazole in the management of hydatid cyst liver. Saudi J Gastroenterol. 2011;17:343-347.
16. Arif SH, Shams Ul B, Wani NA, et al. Albendazole as an adjuvant to the standard surgical management of hydatid cyst liver. Int J Surg. 2008;6:448-451.
17. Türkçapar AG, Ersöz S, Güngör C, Aydinuraz K, Yerdel MA, Aras N. Surgical treatment of hepatic hydatidosis combined with perioperative treatment with albendazole. Eur J Surg. 1997;163:923-928.
18. Aktan AO, Yalin R. Preoperative albendazole treatment for liver hydatid disease decreases the viability of the cyst. Eur J Gastroenterol Hepatol. 1996;8:877-879.
19. Manterola C, Mansilla JA, Fonseca F. Preoperative albendazole and scolices viability in patients with hepatic echinococcosis. World J Surg. 2005;29:750-753.
20. Bildik N, Cevik A, Altintaş M, Ekinci H, Canberk M, Gülmen M. Efficacy of preoperative albendazole use according to months in hydatid cyst of the liver. J Clin Gastroenterol. 2007;41:312-316.
21. Erzurumlu K, Hökelek M, Gönlüsen L, Tas K, Amanvermez R. The effect of albendazole on the prevention of secondary hydatidosis. Hepatogastroenterology. 2000;47:247-250.
Files
IssueVol 17 No 4 (2022) QRcode
SectionOriginal Article(s)
DOI https://doi.org/10.18502/ijpa.v17i4.11274
Keywords
Albendazole Hydatid cyst Echinococcus granulosus
Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
1.
Vahidirad A, Mansouri M, Shamshirian A, Berenji F, Motie MR. Efficacy of Preoperative Albendazole on Protoscoleces Viability in Hydatid Cyst of the Liver. Iran J Parasitol. 2022;17(4):483-487.