Clinicopathological Review of Human Coenurosis in Kwazulu-Natal, South Africa: A Retrospective Single Center Study
Background: To describe the clinicopathological features of human coenurosis diagnosed at a single center in an academic Anatomical Pathology Laboratory, KwaZulu-Natal, South Africa.
Methods: This was a 10-year retrospective laboratory based study, from 2011-2020, which reappraised the clinical presentation, histomorphological tissue reaction patterns and outcomes in patients diagnosed with coenurosis.
Results: Five cases of coenurosis and 19 cases of cysticercosis were diagnosed during the study period. Following re-appraisal of the slides, 6 cases of coenurosis were confirmed and included in the study cohort. The anatomical distribution of disease was as follows: brain (1), liver (1), eye (1) and soft tissue (3). There were 3 males and 3 females and the patients’ age ranged from 2 to 46 (mean 22.2) yr. Three patients were HIV positive whilst the clinical history of the infection was not available for the other 3 patients. All patients presented with mass effect related symptoms, ranging from headache to a painful soft tissue swelling. Two cases displayed synovial metaplasia in addition to characteristic chronic subacute inflammation and fibrosis. One case had supportive inflammation. Two cases comprised of coenuri exclusively and therefore it was not possible to assess tissue reaction.
Conclusion: We describe the first cases of human coenurosis in HIV positive patients and for the first time report synovial metaplasia as one of the reaction patterns of coenurosis. Whenever cysticercosis and hydatidosis are considered clinically, a negative serology should prompt clinicians to consider coenurosis in addition to the neoplastic diagnostic considerations.
2. Yamazawa E, Ohno M, Satomi K, et al. First case of human neurocoenurosis caused by Taenia serialis: A case report. Int J Infect Dis. 2020;92:171-174. doi:10.1016/j.ijid.2020.01.004.
3. Vaughan PJ, Connor DH. Coenurosis. In Pathology of infectious diseases. Vol. 1. Stamford, Connecticut: Appleton and Lange; 1997; 1361-1364.
4. Ing MB, Schantz PM, Turner JA. Human coenurosis in North America: case reports and review. Clin Infect Dis. 1998; 27(3):519-523. doi:10.1086/514716.
5. Ali SM, Reddy PS, Venugopal S, Chhabra M, Mahadevan A. Cerebral Coenurosis Masquerading as Malignancy: A Rare Case Report from India. J Neurosci Rural Pract. 2019;10(2):367-370. doi:10.4103/jnrp.jnrp_296_18.
6. Watson KC, Laurie W. Cerebral coenu-rosis in man. The Lancet. 1955; Dec24:1321-1322.
7. El-On J, Shelef I, Cagnano E, Benifla M. Taenia multiceps: a rare human cestode infec-tion in Israel. Vet Ital. 2008; 44(4):621-631.
8. Michal A, Regli F, Campiche R, et al. Cere-bral coenurosis. Report of a case with arte-ritis. J Neurol. 1977; 216(4):265-272. doi:10.1007/BF00314050.
9. Wilson VC, Wayte DM, Addae RO. Hu-man coenurosis--the first reported case from Ghana. Trans R Soc Trop Med Hyg. 1972; 66(4):611-623.
10. Malomo A, Ogunniyi J, Ogunniyi A, Akang EE, Shokunbi MT. Coenurosis of the central nervous system in a Nigerian. Trop Geogr Med. 1990; 42(3):280-282.
11. Lescano AG, Zunt J. Other cestodes: sparganosis, coenurosis and Taenia crassiceps cysticercosis. Handb Clin Neurol. 2013; 114:335-345. doi:10.1016/B978-0-444-53490-3.00027-3.
12. FAIN A. Coenurus of Taenia brauni Setti parasitic in man and animals from the Bel-gian Congo and Ruanda-Urundi. Nature. 1956; 178(4546):1353. doi:10.1038/1781353a0.
13. Delobel P, Signate A, El Guedj M, et al. Unusual form of neurocysticercosis asso-ciated with HIV infection. Eur J Neurol. 2004; 11(1):55-58. doi:10.1046/j.1351-5101.2003.00696.x.
14. Kermani H, Dehghani N, Dehghani S, et al. Cutaneous Metaplastic Synovial Cyst: A Case Report and Literature Review. Iran Red Crescent Med J. 2015; 17(12):e22467. Published 2015 Dec 28. doi:10.5812/ircmj.22467.
15. Kim BC, Choi WJ, Park EJ, et al. Cutane-ous metaplastic synovial cyst of the first metatarsal head area. Ann Dermatol. 2011; 23(Suppl 2):S165-S168. doi:10.5021/ad.2011.23.S2.S165.
16. Ramdial PK, Singh Y, Singh B. Metaplastic synovial cyst in male breast. Ann Diagn Pathol. 2005; 9(4):219-222.
17. Amrabadi O, Oryan A, Moazeni M, Shari-Fiyazdi H, Akbari M. Histopathological and Molecular Evaluation of the Experi-mentally Infected Goats by the Larval Forms of Taenia multiceps. Iran J Parasitol. 2019; 14(1):95-105.
|Issue||Vol 17 No 1 (2022)|
|Coenuriasis Taeniasis Histopathology South Africa|
|Rights and permissions|
|This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.|