The First Identification of Encephalitozoon cuniculi Infection in an Animal Care Worker in Turkey
Background: As a zoonotic pathogen, Encephalitozoon cuniculi is a cause of serious disease in animals and people. The present study was to evaluate the health status examination of this seropositive animal care worker in our pre-vious study.
Methods:Blood samples were taken from five workers. CIA test was ap-plied to detect antibodies against E. cuniculi in blood serum. The indirect immunofluorescence antibody test was used as confirmation test. Seroposi-tive worker had a complete medical examination.
Results:Only one worker was found to be seropositive according to the results of the serological test. Sera positive to E. cuniculi was confirmed with IFAT and spores were detected in the urine sample of the worker. The worker was treated with albendazole.
Conclusion:Rabbits should be examined routinely for the presence of anti-E. cuniculi antibody. People working with laboratory animal should avoid contact with urine and faeces of infected or pay attention to personal hy-giene.
Weber R, Bryan RT, Schwartz DA, Owen RL. Human Microsporidial infections. Clin Micro-biol Rev. 1994; 7: 426-61.
Mathis A, Weber R, Deplazes P. Zoonotic potential of the microsporidia. Clin Microbiol Rev. 2005; 18: 423–445.
Furuya K. Spore-forming microsporidian En-cephalitozoon: current understanding of infection and prevention in Japan. Jpn J Infect Dis. 2005; 62: 413-422.
Deplazes P, Mathis A, Baumgartner R, Tanner I, Weber, R. Immunologic and molecular characteristics of Encephalitozoon-like micro-sporidia isolated from humans and rabbits in-dicate that Encephalitozoon cuniculi is a zoonotic parasite. Clin Infect Dis. 1996; 22: 557-9.
Rossi P, La Rosa G, Ludovisi A, Tamburrini A, Gomez Morales MA, PozioE. Identifica-tion of a human isolate of Encephalitozoon cunic-uli type I from Italy. Int J Parasitol. 1998; 28: 1361–6.
Cislakova L, Halanova M. Microsporidial in-fections in immunocompromised hospitalised patients. Indoor Built Environ. 2003; 12(1/2): 37-9.
Halánová M, Cisláková L, Valencákova A, Bálent P, Adam J, Trávnicek M. Serological screening of occurrence of antibodies to En-cephalitozoon cuniculi in humans and animals in Eastern Slovakia. Ann Agric Environ Med. 2003: 10: 117–20.
Jeklova E, Jekl V, Kovarcik K, Hauptman K, Koudela B, Neumayerova et al. Usefulness of detection of specific IgM and IgG antibodies for diagnosis of clinical encephalitozoonosis in pet rabbits. Vet Parasitol. 2010; 170: 143–8.
Malcekova B, Halanova M, Sulinova Z, Molnar L, Ravaszova P, Adam J, et al. Sero-prevalence of antibodies to Encephalitozoon cu-niculi and Encephalitozoon intestinalis in humans and animals. Res Vet Sci. 2010; 89(3):358-6.
Hollister WS, Canning EU, Colbourn NI, Aa-rons EJ. Encephalitozoon cuniculi isolated from the urine of an AIDS patient, which differs from canine and murine isolates. J Eukaryot Microbiol. 1995; 42(4): 367–2.
Berkin S, Kahraman MM. Türkiye’de tavşan-larda Encephalitozoon (Nosema) cuniculi en-feksiyonu. Ankara Üniv Vet Fak Derg. 1983; 30: 397-06.
Eroksuz H, Eroksuz Y, Metin N, Ozer H. Morphologic examinations of cases of natu-rally acquired encephalitozoonosis in a rabbit colony. Turkish J Vet Animal Sci. 1999a; 23: 191-195.
Ozkan O, Ozkan AT, Zafer Z. Encephalito-zoonosis in New Zealand rabbits and potential transmission risk. Vet Parasitol. 2011; 179(1–3): 234–7.
Eroksuz Y, Eroksuz H, Ozer H, Cevik A, Un-ver O. A survey of encephalitozoon cuniculi infection in rabbit colonies in Elazıg, Turkey: pathomorphologic and serologic (Carbonim-munoassay test) studies. Isr J Vet Med. 1999b; 54(3): 73-77.
Chalupský J, Vávra J, Bedrník P.Detection of antibodies to Encephalitozoon cuniculi in rabbits by the indirect immunofluorescent antibody test. Folia Parasitol. 1973; 20: 281–284.
Ryan NJ, Sutherland G, Coughlan K, Globan M, Doultree J, Mashall J, et al. A new tri-chrome-blue stain for detection of microspor-idial species in urine, stool, and naso-pharyngeal specimens. J Clin Microbiol. 1993; 3264–9.
Buget E, Buyukbaba-Boral O, Kırkoyun-Uysal H, Nazlıcan O, Ogut T, Sengur G. First Case Report in Turkey: Microsporidiosis and Pul-monary Cryptosporidiosis in an AIDS Patient. Turkish Microbiol Soc. 2000; 30: 166-170.
Yazar S, Eser B, Yalcin S, Sahin I, Koc AN. A case of pulmonary microsporidiasis in an acute myeloblastic leukaemia (AML) - M3 patient. Yonsei Med J. 2003: 44: 146-9.
Atambay M, Karaman Ü, Daldal N, Çolak C. The Prevalence of Microsporidium among Adult Patients Admitted to the Parasitology Labora-tory at the Inonu University Turgut Ozal Medical Center. Turkish J Parasitol. 2008; 32: 113-5.
Karaman Ü, Atambay M, Daldal N, Çolak C. The Prevalence of Microsporidium among Pa-tients Given a Diagnosis of Cancer. Turkish J Parasitol. 2008; 32: 109-12.
Matsubayashi H, Koike T, Mikate T, Hagiwara S.A case Encephalitozoon-like. body infection in man. Arch Pathol. 1959; 67: 181-187.
Harcourt-Brown FM. Encephalitozoon cuniculi Infection in Rabbits. Seminars in Avian and Exotic Pet Medicine. 2004; 13(2): 86-3.
Jordan CN, Zajac AM, Lindsay DS. Encepha-litozoon cuniculi infections in rabbits. Comp Cont Educ Pract Vet. 2006; 28: 108–16.
Valenčáková A, Balent P, Petrovova E, No-votny F, Luptakova L. Encephalitozoonosis in household pet Nederland Dwarf rabbits (Oryctolagus cuniculus). Vet Parasitol. 2008; 153: 265-9.
Didier ES. Microsporidiosis: an emerging and opportunistic infection in humans and ani-mals. Acta Trop. 2005; 94(1): 61–6.
26.Reetz J, Nöckler K, Reckinger S, Vargas MM, Weiske W, Broglia A. Identification of Encephalitozoon cuniculi genotype III and two novel genotypes of Enterocytozoon bieneusi in swine. Parasitol Int. 2009; 58: 285–292.
De Groote MA, Visvesvara G, Wilson ML, Pieniazek NJ, Slemenda SB, et al. Polymerase chain reaction and culture confirmation of dis-seminated Encephalitozoon cuniculi in a patient with AIDS: successful therapy with albend-azole. J Infect Dis. 1995; 171: 1375–78.
|Issue||Vol 10 No 2 (2015)|
|Animal care worker Encephalitozoon cuniculi|
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