Determining the Frequency of Cystic Echinococcosis among Suspected Cases Referred to Health Centers Southwest Iran, and Post-Treatment Serologic Follow-Up
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Abstract
Background: This study was designed to determine the frequency of hydatidosis in Khuzestan Province, Iran and to evaluate the antibody changes in infected individuals after treatment.
Methods: Overall, 454 sera were collected from health centers of Khuzestan Province, southern Iran (from 2013 to 2018). Demographic data such as age, gender and history of disease were recorded. Serum samples were investigated for antibody against CE by ELISA using antigen B. Thirty six of cases were followed up after treatment.
Results: Among the 454 evaluated cases, antibody against CE was detected in 184 (40.52%) including 115 (62.5%) females and 69 (37.5%) males. Age distribution was from 8-97 yr, the highest prevalence of hydatid cyst was observed in age group 40-49 years. Liver was the most infected organ (76.63%). Relapse of CE occurred in 23 of patients. In the majority of patients the antibody decreased, whereas in some cases increased CE antibody observed during post-treatment follow up.
Conclusion: Current study indicated the high prevalence of hydatidosis and rate of relapse after treatment among suspected patients. Therefore, long periods and regular follow-up of patients after treatment is necessary and for these monitoring, antibody assay can be an appropriate method.
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11. Karami MF, Maraghi S, Rafiei A, et al. Comparison of Sensitivity and Specificity of Native ELISA Test (Prepared in Khouzestan, Iran) and Commercial ELISA Kit in the Diagnosis of Human Hydatidosis. Zahedan Journal of Research in Medical. 2019; 21(4): e91416.
12. Beyhan YE, Babür C, Mungan M, et al. Evaluation of cystic echinococcosis suspected patients applied to national parasitology reference laboratory of public health institution of Turkey between 2009-2013. Turkiye Parazitol Derg. 2015; 39(1):17-21.
13. Madiyal M, Banerjee B, George AK, et al. Role of Serology in Diagnosis of Human Hydatidosis: Experience from a Tertiary Care Hospital. International Journal of Current Microbiology and Applied Sciences. 2016; 5(12):195-202.
14. Griffin DO, Donaghy HJ, Edwards B. Management of serology negative human hepatic hydatidosis (caused by Echinococcus granulosus) in a young woman from Bangladesh in a resource-rich setting: A case report. IDCases. 2014; 1(2):17-21.
15. Manzano-Román R, Sánchez-Ovejero C, Hernández-González A, et al. Serological diagnosis and follow-up of human cystic echinococcosis: a new hope for the future? Biomed Res Int. 2015;2015:428205.
16. Kamali M, Yousefi F, Mohammadi MJ, et al. Hydatid cyst epidemiology in Khuzestan, Iran: A 15-year evaluation. Archives of Clinical Infectious Diseases. 2018; 13(1):e13765.
17. Fallah N, Rahmati K, Fallah M. Prevalence of Human Hydatidosis Based on Hospital Records in Hamadan West of Iran from 2006 to 2013. Iran J Parasitol. 2017; 12(3):453-460.
18. Rezaei F, Saghafipour A, Sheikholeslami NZ, et al. Investigation of demographic and clinical status of sufferers of hydatid cysts referred to hospitals affiliated to Qom University of Medical Sciences during a 12-year period (2002-2013), Iran. Qom Univ Med Sci J. 2014; 8(5):63-67.
19. Hajipirloo HM, Bozorgomid A, Alinia T, et al. Human cystic echinococcosis in west azerbaijan, northwest Iran: a retrospective hospital based survey from 2000 to 2009. Iran J Parasitol. 2013; 8(2):323-6.
20. Sarkari B, Hosseini F, Khabisi SA, et al. Seroprevalence of cystic echinococcosis in blood donors in Fars province, southern Iran. Parasite Epidemiol Control. 2016; 2(1):8-12.
21. Heidari Z, Mohebali M, Zarei Z, et al. Seroepidemiological study of human hydatidosis in Meshkinshahr district, Ardabil province, Iran. Iran J Parasitol. 2011; 6(3):19-25.
22. Asghari M, Mohebali M, Eshrat Beigom K, et al. Seroepidemiology of human hydatidosis using AgB-ELISA test in Arak, central Iran. Iran J Public Health. 2011; 44(9): 1219–1224.
23. Rafiei A, Jahanshahi A, Talaeizadeh A. Evaluation of specific IgG antibody detection in diagnosis and post surgical monitoring of cystic echinococcosis. Iran J Parasitol. 2008; 3(2):10-14.
24. Lawn SD, Bligh J, Craig PS, et al. Human cystic echinococcosis: evaluation of post-treatment serologic follow-up by IgG subclass antibody detection. Am J Trop Med Hyg. 2004; 70(3):329-35.
25. Piccoli L, Tamarozzi F, Cattaneo F, et al. Long-term sonographic and serological follow-up of inactive echinococcal cysts of the liver: hints for a “watch-and-wait” approach. PLoS Negl Trop Dis. 2014; 8(8):e3057.
2. Neumayr A, Tamarozzi F, Goblirsch S , et al. Spinal cystic echinococcosis–a systematic analysis and review of the literature: part 1. Epidemiology and anatomy. PLoS Negl Trop Dis.2013; 7(9):e2458.
3. Brunetti E, Garcia HH, Junghanss T. Cystic echinococcosis: chronic, complex, and still neglected. PLoS Negl Trop Dis. 2011; 5(7):e1146.
4. Sarkari B, Rezaei Z. Immunodiagnosis of human hydatid disease: where do we stand? World J Methodol. 2015; 5(4):185-95.
5. Tenguria RK, Naik MI. Evaluation of human cystic echinococcosis before and after surgery and chemotherapy by demonstration of antibodies in serum. Ann Parasitol. 2014; 60(4):297-303.
6. Rafiei A, Hemadi A, Maraghi S, et al. Human cystic echinococcosis in nomads of south-west Islamic Republic of Iran. East Mediterr Health J. 2007; 13(1):41-8
7. Sadjjadi SM. Present situation of echinococcosis in the Middle East and Arabic North Africa. Parasitol Int. 2006;55:S197-202.
8. Rokni M. Echinococcosis/hydatidosis in Iran. Iran J Parasitol. 2009; 4(2):1-16.
9. Harandi MF, Budke CM, Rostami S . The monetary burden of cystic echinococcosis in Iran. PLoS Negl Trop Dis. ;20126(11):e1915.
10. Sadjjadi SM, Sedaghat F, Hosseini SV, et al. Serum antigen and antibody detection in echinococcosis: application in serodiagnosis of human hydatidosis. Korean J Parasitol. 2009; 47(2):153-157.
11. Karami MF, Maraghi S, Rafiei A, et al. Comparison of Sensitivity and Specificity of Native ELISA Test (Prepared in Khouzestan, Iran) and Commercial ELISA Kit in the Diagnosis of Human Hydatidosis. Zahedan Journal of Research in Medical. 2019; 21(4): e91416.
12. Beyhan YE, Babür C, Mungan M, et al. Evaluation of cystic echinococcosis suspected patients applied to national parasitology reference laboratory of public health institution of Turkey between 2009-2013. Turkiye Parazitol Derg. 2015; 39(1):17-21.
13. Madiyal M, Banerjee B, George AK, et al. Role of Serology in Diagnosis of Human Hydatidosis: Experience from a Tertiary Care Hospital. International Journal of Current Microbiology and Applied Sciences. 2016; 5(12):195-202.
14. Griffin DO, Donaghy HJ, Edwards B. Management of serology negative human hepatic hydatidosis (caused by Echinococcus granulosus) in a young woman from Bangladesh in a resource-rich setting: A case report. IDCases. 2014; 1(2):17-21.
15. Manzano-Román R, Sánchez-Ovejero C, Hernández-González A, et al. Serological diagnosis and follow-up of human cystic echinococcosis: a new hope for the future? Biomed Res Int. 2015;2015:428205.
16. Kamali M, Yousefi F, Mohammadi MJ, et al. Hydatid cyst epidemiology in Khuzestan, Iran: A 15-year evaluation. Archives of Clinical Infectious Diseases. 2018; 13(1):e13765.
17. Fallah N, Rahmati K, Fallah M. Prevalence of Human Hydatidosis Based on Hospital Records in Hamadan West of Iran from 2006 to 2013. Iran J Parasitol. 2017; 12(3):453-460.
18. Rezaei F, Saghafipour A, Sheikholeslami NZ, et al. Investigation of demographic and clinical status of sufferers of hydatid cysts referred to hospitals affiliated to Qom University of Medical Sciences during a 12-year period (2002-2013), Iran. Qom Univ Med Sci J. 2014; 8(5):63-67.
19. Hajipirloo HM, Bozorgomid A, Alinia T, et al. Human cystic echinococcosis in west azerbaijan, northwest Iran: a retrospective hospital based survey from 2000 to 2009. Iran J Parasitol. 2013; 8(2):323-6.
20. Sarkari B, Hosseini F, Khabisi SA, et al. Seroprevalence of cystic echinococcosis in blood donors in Fars province, southern Iran. Parasite Epidemiol Control. 2016; 2(1):8-12.
21. Heidari Z, Mohebali M, Zarei Z, et al. Seroepidemiological study of human hydatidosis in Meshkinshahr district, Ardabil province, Iran. Iran J Parasitol. 2011; 6(3):19-25.
22. Asghari M, Mohebali M, Eshrat Beigom K, et al. Seroepidemiology of human hydatidosis using AgB-ELISA test in Arak, central Iran. Iran J Public Health. 2011; 44(9): 1219–1224.
23. Rafiei A, Jahanshahi A, Talaeizadeh A. Evaluation of specific IgG antibody detection in diagnosis and post surgical monitoring of cystic echinococcosis. Iran J Parasitol. 2008; 3(2):10-14.
24. Lawn SD, Bligh J, Craig PS, et al. Human cystic echinococcosis: evaluation of post-treatment serologic follow-up by IgG subclass antibody detection. Am J Trop Med Hyg. 2004; 70(3):329-35.
25. Piccoli L, Tamarozzi F, Cattaneo F, et al. Long-term sonographic and serological follow-up of inactive echinococcal cysts of the liver: hints for a “watch-and-wait” approach. PLoS Negl Trop Dis. 2014; 8(8):e3057.
| Files | ||
| Issue | Vol 16 No 2 (2021) | |
| Section | Short Communication(s) | |
| DOI | https://doi.org/10.18502/ijpa.v16i2.6311 | |
| Keywords | ||
| Cystic echinococcosis Hydatid cyst Iran Antibody detection | ||
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Rafiei A, Biranvand E, Nazari I, Bahraini A. Determining the Frequency of Cystic Echinococcosis among Suspected Cases Referred to Health Centers Southwest Iran, and Post-Treatment Serologic Follow-Up. Iran J Parasitol. 2021;16(2):312-317.
