Prevalence of Opisthorchis viverrini and its Associated Risk Factors in the Phon Sawan District of Nakhon Phanom Province, Thailand
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Abstract
Background: Opisthorchis viverrini is one of the endemic helminths in Thailand. Nonetheless, O. viverrini still exist and raise concerns regarding public health. This study aimed to evaluate the current prevalence of O. viverrini infections and underlying risk factors among rural communities in Northeast Thailand.
Methods: A cross-sectional study was conducted between Sep and Dec 2019 in Phon Sawan district in Nakhon Phanom Province, Thailand. The participants were selected using a voluntary sampling method after the proportional allocation of the total sample size. Demographic data were collected using a standardized questionnaire. One stool sample was collected from each participant and the presence of O. viverrini and other intestinal parasite infections were determined using the modified Kato-Katz technique.
Results: Overall, 250 participants aged 21 yr or older were enrolled. Overall, the prevalence of O. viverrini and Strongyloides stercoralis was 24% (95% confidence interval [CI]: 18.8-29.8) and 1.2% (95% CI: 0.2-3.5), respectively. Of the positive O. viverrini cases, the parasite rate significantly differed between gender, age group and in those who had a history of eating raw fish and taking the anti-helminthic drug (all P<0.05). Nevertheless, multivariate regression analysis among O. viverrini cases revealed that only being male (adjusted odds ratio [aOR] 1.9 [95% CI: 1.1 – 3.6], P = 0.033) and aged ≥61 yr (aOR 6.7 [95% CI: 1.4 – 32.5], P=0.018) were positively associated with a higher risk of O. viverrini infection.
Conclusion: Opisthorchiasis and strongyloidiasis are still endemic in this area and there is a need for projects to eliminate these parasites.
2. Sithithaworn P, Andrews RH, Nguyen VD, et al. The current status of opisthorchiasis and clonorchiasis in the Mekong Basin. Parasitol Int. 2012;61(1):10-6.
3. Suwannatrai A, Saichua P, Haswell M. Epidemiology of Opisthorchis viverrini infection. Adv Parasitol. 2018;101:41-67.
4. Sripa B, Kaewkes S, Sithithaworn P, et al. Liver fluke induces cholangiocarcinoma. PLoS Med. 2007;4(7):e201.
5. Bouvard V, Baan R, Straif K, et al. A review of human carcinogens--Part B: biological agents. Lancet Oncol. 2009;10(4):321-2.
6. Laoraksawong P, Sanpool O, Rodpai R, et al. Current high prevalences of Strongyloides stercoralis and Opisthorchis viverrini infections in rural communities in northeast Thailand and associated risk factors. BMC Public Health. 2018;18(1):940.
7. Kaewpitoon SJ, Sangwalee W, Kujapun J, et al. Active screening of gastrointestinal helminth infection in migrant workers in Thailand. J Int Med Res. 2018;46(11):4560-8.
8. Sripa B, Tangkawattana S, Laha T, et al. Toward integrated opisthorchiasis control in northeast Thailand: the Lawa project. Acta Trop. 2015;141(Pt B):361-7.
9. Khuntikeo N, Chamadol N, Yongvanit P, et al. Cohort profile: cholangiocarcinoma screening and care program (CASCAP). BMC Cancer. 2015;15:459.
10. Chuangchaiya S, Laoprom N, Idris, ZM. Prevalence and associated risk factors of Opisthorchis viverrini infections in rural communities along the Nam Kam River of Northeastern Thailand. Trop Biomed. 2019;36(1):81-93.
11. Chuangchaiya S, Navanesan S, Jaichuang S, et al. Current prevalence of Opisthorchis viverrini infection and associated risk factors in Nakhon Phanom Province, Northeastern Thailand. Trop Biomed. 2020;37(4):986-999.
12. Kaewpitoon N, Kaewpitoon SJ, Pengsaa P. Opisthorchiasis in Thailand: review and current status. World J Gastroenterol. 2008;14(15):2297-302.
13. Laoprom N, Prathummang S, Chuangchaiya S, et al. Opisthorchis viverrini metacercarial infection in cyprinid fish in Nakhon Phanom Province, Northeastern Thailand. Trop Biomed. 2021;38(2):25-30.
14. Nontasut P, Muennoo C, Sa-nguankiat S, et al. Prevalence of strongyloides in Northern Thailand and treatment with ivermectin vs albendazole. Southeast Asian J Trop Med Public Health. 2005;36(2):442-4.
15. Kitvatanachai S, Boonsilp S, Watanasatitarpa S. Intestinal parasitic infections in Srimum suburban area of Nakhon Ratchasima Province, Thailand. Trop Biomed. 2008;25(3):237-42.
16. Sayasone S, Vonghajack Y, Vanmany M, et al. Diversity of human intestinal helminthiasis in Lao PDR. Trans R Soc Trop Med Hyg. 2009;103(3):247-54.
17. Janwan P, Intapan PM, Thanchomnang T, et al. Rapid detection of Opisthorchis viverrini and Strongyloides stercoralis in human fecal samples using a duplex real-time PCR and melting curve analysis. Parasitol Res. 2011;109(6):1593-601.
18. Kaewpitoon SJ, Ponphimai S, Pechdee P, et al. The prevalence of intestinal helminth infection in rural subdistricts of northeastern Thailand. Trop Biomed. 2019;36(1):152-64.
19. Thaewnongiew K, Singthong S, Kutchamart S, et al. Prevalence and risk factors for Opisthorchis viverrini infections in upper Northeast Thailand. Asian Pac J Cancer Prev. 2014;15(16):6609-12.
20. Sriamporn S, Pisani P, Pipitgool V, et al. Prevalence of Opisthorchis viverrini infection and incidence of cholangiocarcinoma in Khon Kaen, Northeast Thailand. Trop Med Int Health. 2004;9(5):588-94.
21. Kaewpitoon SJ, Rujirakul R, Kaewpitoon N. Prevalence of Opisthorchis viverrini infection in Nakhon Ratchasima province, Northeast Thailand. Asian Pac J Cancer Prev. 2012;13(10):5245-9.
22. Saengsawang P, Promthet S, Bradshaw P. Prevalence of OV infection in Yasothon Province, Northeast Thailand. Asian Pac J Cancer Prev. 2012;13(7):3399-402.
23. Songserm N, Promthet S, Wiangnon S, et al. Prevalence and co-infection of intestinal parasites among Thai rural residents at high-risk of developing cholangiocarcinoma: a cross-sectional study in a prospective cohort study. Asian Pac J Cancer Prev. 2012;13(12):6175-9.
24. Chudthaisong N, Promthet S, Bradshaw P. Risk factors for Opisthorchis viverrini infection in Nong Khai Province, Thailand. Asian Pac J Cancer Prev. 2015;16(11):4593-6.
25. Nakbun S, Thongkrajai P, Nithikathkul C . Risk factors for Opisthorchis viverrini infection in Nakhon Phanom, Thailand, where the infection is highly endemic. Asian Biomedicine. 2018;12(1):45-51.
26. Forrer A, Sayasone S, Vounatsou P, et al. Spatial distribution of, and risk factors for Opisthorchis viverrini infection in southern Lao PDR. PLoS Negl Trop Dis. 2012;6(2):e1481.
27. Yong TS, Shin EH, Chai JY, et al. High prevalence of Opisthorchis viverrini infection in a riparian population in Takeo Province, Cambodia. Korean J Parasitol. 2012;50(2):173-6.
28. Andrews RH, Sithithaworn P, Petney TN. Opisthorchis viverrini: an underestimated parasite in world health. Trends Parasitol. 2008;24(11):497-501.
29. Steinmann P, Utzinger J, Du ZW, et al. Efficacy of single-dose and triple-dose albendazole and mebendazole against soil-transmitted helminths and Taenia spp.: a randomized controlled trial. PLoS One. 2011;6(9):e25003.
30. Phongluxa K, Xayaseng V, Vonghachack Y, et al. Helminth infection in southern Laos: high prevalence and low awareness. Parasit Vectors. 2013;6(1):328.
31. Boonjaraspinyo S, Boonmars T, Kaewsamut B, et al. A cross-sectional study on intestinal parasitic infections in rural communities, northeast Thailand. Korean J Parasitol. 2013;51(6):727-34.
32. Prasongdee TK, Laoraksawong P, Kanarkard W, et al. An eleven-year retrospective hospital-based study of epidemiological data regarding human strongyloidiasis in northeast Thailand. BMC Infect Dis. 2017;17(1):627.
| Files | ||
| Issue | Vol 16 No 3 (2021) | |
| Section | Original Article(s) | |
| DOI | https://doi.org/10.18502/ijpa.v16i3.7101 | |
| Keywords | ||
| Opisthorchis viverrini; Foodborne trematode; Epidemiology Thailand | ||
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