Interleukin-18 Antagonism Improved Histopathological Conditions of Malaria Infection in Mice
-
Marzieh JABBARZARE
,
Voon Kin CHIN
,
Herni TALIB
,
Mun Fei YAM
,
Siti Khadijah ADAM
,
Haniza HASSAN
,
Roslaini ABDUL MAJID
,
Che Norma MAT TAIB
,
Mohamad Aris MOHD MOKLAS
,
Mohamad TAUFIK HIDAYAT
,
Hasidah MOHD SIDEK
,
Rusliza BASIR
Abstract
Background: Interleukin 18 (IL-18) exerts pleiotropic roles in many inflammatory-related diseases including parasitic infection. Previous studies have demonstrated the promising therapeutic potential of modulating IL-18 bioactivity in various pathological conditions. However, its involvement during malaria infection has yet to be established. In this study, we demonstrated the effect of modulating IL-18 on the histopathological conditions of malaria infected mice.
Methods: Plasmodium berghei ANKA infection in male ICR mice was used as a model for malaria infection. Modulation of IL-18 release was carried out by treatment of malarial mice with recombinant mouse IL-18 (rmIL-18) and recombinant mouse IL-18 Fc chimera (rmIL-18Fc) intravenously. Histopathological study and analysis were performed on major organs including brain, liver, spleen, lungs and kidney.
Results: Treatment with rmIL-18Fc resulted in significant improvements on the histopathological conditions of the organs in malaria-infected mice.
Conclusion: IL-18 is an important mediator of malaria pathogenesis and targeting IL-18 could prove beneficial in malaria-infected host.
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| Issue | Vol 10 No 3 (2015) | |
| Section | Original Article(s) | |
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| Malaria Interleukin-18 Plasmodium berghei Histopathology | ||
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