Original Article

Predisposing Factors to Lymphatic Filariasis among Residents in Igbo-Eze North; an Endemic Area in Nigeria


Background: The study on lymphatic filariasis (LF) in Igbo-Eze North was conducted to determine the prevalence and predisposing factors to LF among its residents between May and October 2018.

Methods: A total of 201 residents who have lived in the area for at least one year were recruited. They were stratified according to age, gender and occupation, and were clinically examined firstly by rapid assessment method for any lymphoedema and hydrocele. At recruitment, blood samples were collected from all volunteered participants for LF test. In addition, demographic information and risk factors of the respondents were captured using a structured questionnaire by oral interview.

Results: The overall prevalence for LF was 84 (41.8%). Furthermore, LF prevalence was significant (P < 0.05) in all the studied communities: 61.5% in Umuogbuagu, 48.1% in Aguibege, 32.7% in Umuagama and 21.7% in Umuopu. The sex-related prevalence of LF was higher among females than males, with slight significant difference (P = 0.046). In relation to age and occupation, higher prevalences (P < 0.0001) were recorded among older (≥ 50 years) subjects (49, 61.2%) and traders (55, 57.9%) respectively. The risk associated with LF implicated lack of knowledge, non-use of mosquito nets, as well as visit and proximity to water bodies as major predispositions (P < 0.05).

Conclusion: The prevalence of LF in this study was high. Higher prevalence was among females, older people and traders. Notable risks to the disease outcome are environmental, attitudinal and occupational with chances of scaled up prevalence and burden overtime.

1. WHO. Meeting of the international task force for disease eradication—October 2010. Weekly Epidem Rec. 2011; 86: 53-59.
2. Sabesan S, Vanamail P, Raju, KHK, et al. Lymphatic filariasis in India: epidemiology and control measures. J Postgrad Med. 2010; 56(3): 232-8.
3. Arora DR, Arora BB. Medical Parasitology. Third Edition. CBS Publishers and Dis-tributors, New Delhi, India, 2014.
4. Omudu EA Okafor FC. Rapid epidemio-logical and socio-cultural appraisal of lym-phatic filariasis amongst the Igede ethnic group in Benue State, Nigeria. Nigerian J Para. 2007; 28(2): 118 – 124.
5. Krentel A, Fischer P, Manoempil P, et al. Using knowledge, attitudes and practice (KAP) surveys on lymphatic filariasis to prepare a health promotion campaign for mass drug administration in Alor District, Indonesia. Trop Med Intl Health. 2006; 11(11): 1731 - 1740.
6. Omudu EA. Sero-Epidemiological and Socio-Cultural Studies on Lymphatic Filari-asis in Benue State, Nigeria. A Ph.D. Un-published Thesis submitted to the De-partment of Zoology, Faculty of Biological Sciences, University of Nigeria, Nsukka, 2008.
7. Norões J, Addiss D, Amaral F, et al. Oc-currence of living adult Wuchereria bancrofti in the scrotal area of men with micro-filaraemia. Trans Roy Soc Trop Med Hyg. 1996; 90(1): 55-56.
8. Chandrakala G, Zulfeen M. Filariasis in pregnancy: prevalent yet less known global health burden. J Basic Clin Rep Sci. 2016; 5(2): 107 - 109.
9. Das N, Das N. Treatment of tropical diseases. World Sci News. 2016; 45(1): 61 - 62.
10. National Population Commission (2007). 2006 national population and housing census. Federal Republic of Nigeria Offi-cial Gazelle, Lagos, 15th May, volume 94, number 24.
11. Sarmukaddam S, Garad S. On validity of assumptions while determining sample size. Indian J Comm Med. 2004; 29: 87 – 91.
12. Nwoke BEB, Dozie INS, Jiya J, et al. The prevalence of hydrocoele in Nigeria and its implication on mapping of lymphatic fila-riasis. Nigerian J Para. 2006; 27: 29 - 35.
13. Cheesbrough M. District Laboratory Prac-tice in Tropical Countries. Second Edition. Cambridge University Press, Cape Town, South Africa, 2006.
14. Nwosu CG, Ivoke N, Okoye IC, et al. As-sessment of the obstetric, demographic and economic burden on falciparum-malaria parasitaemia among women of child-bearing age receiving antenatal services in Nsukka, Nigeria. Intl J Sci Tech. 2018; 6(2): 193 – 200.
15. Iboh CI, Okon OE, Opara KN, et al. Lymphatic filariasis among the Yakurr people of Cross River State, Nigeria. Para-sites and Vectors. 2012; 5: 203.
16. Udoidung NI, Braide IE, Opara KN, et al. Current status of Bancroftian filariasis in rural communities of the Lower Cross River Basin, Nigeria: parasitological and clinical aspects. J Pub Health. 2008; 16: 383 – 388.
17. Targema CN, Onwuliri CO, Mafuya HB, et al. Mapping of lymphatic filariasis in Benue State, Nigeria. Nigerian J Para. 2008; 29(1): 55 – 60.
18. Mbah DC, Njoku OO. Prevalence of lym-phatic filariasis in Oraeri, Aguata Local Government Area of Anambra State, Ni-geria. Nigerian J Para. 2002; 21: 95 – 102.
19. Abel E, Frank OR, Blaney DD, et al. Rapid assessment for lymphatic filariasis in cen-tral Nigeria: a comparison of the immuno-chromatographic and test and hydrocele rates in an area of high endemicity. Am Soc Trop Med Hyg. 2002; 68(6): 643 – 646.
20. Anosike JC, Nwoke BEB, Ajayi EG, et al. Lymphatic filariasis among Ezza people of Ebonyi State, Eastern Nigeria. Annals Agric Environ Med. 2005; 12: 181 – 186.
21. Okon OE, Iboh CI, Opara KN. Bancroft-ian filariasis among the Mbembe people of Cross River State, Nigeria. J Vec Borne Dis. 2010; 47: 91 – 96.
22. Terranella A, Eigiege A, Gontor I, et al. Urban lymphatic filariasis in central Nige-ria. Annals Trop Med Para. 2006; 100: 163 – 172.
23. Christiana O, Olajumoke M, Oyetunde S. Lymphatic filariasis and associated mor-bidities in rural communities of Ogun State, Southwestern Nigeria. Travel Med Infect. 2014; 12(1): 95 – 101.
24. Adekunle NO, Sam-Wobo SO, Adeleke MA, et al. Prevalence and distribution of Wucheria bancrofti in Osse Local Govern-ment Area, Ondo State. Nigerian J Para. 2016; 37(1): 96 – 100.
25. Elkanah OS, Elkanah DS, Wahedi JA, et al. Lymphatic filariasis in Muri Emirate: clinical and parasitological studies in Jalin-go LGA, Taraba State, Nigeria. Asian J Med Health. 2017; 6(1): 1 – 7.
26. Dogara MM, Nock HI, Agbede RIS, et al. Prevalence of lymphatic filariasis in three villages in Kano State, Nigeria. Internet J Trop Med. 2012; 8: 1.
27. Okorie PN, Davies E, Ogunmola OO, et al. Lymphatic filariasis baseline survey in two sentinel sites of Ogun state, Nigeria. Pan Afr Med J. 2015; 20: 397.
28. van den Berg H, Kelly-Hope LA, Lindsay SW. Malaria and lymphatic filariasis: the case for integrated vector management. Lancet Infect Dis. 2013; 13: 89 – 94.
29. Richards FO, Emukah E, Graves PM, et al. Community-wide distribution of long-lasting insecticidal nets can halt transmis-sion of lymphatic filariasis in southeastern Nigeria. Am J Trop Med Hyg. 2013; 89: 578 – 587.
30. Rebollo MP, Sambou SM, Thomas B, et al. Elimination of lymphatic filariasis in the Gambia. PLoS Negl Trop Dis. 2015; 9: 1 – 16.
31. Nsakashalo-Senkwe M, Mwase E, Chize-ma-Kawesha E, et al. Significant decline in lymphatic filariasis associated with nation-wide scale-up of insecticide treated nets in Zambia. Para Epidem Control. 2017; 2(4): 7 – 14.
32. Brant TA, Okorie PN, Ogunmola O, et al. Integrated risk mapping and landscape characterization of lymphatic filariasis and loaiasis in South West Nigeria. Para Epi-dem Control. 2018; 3: 21 – 35.
IssueVol 16 No 4 (2021) QRcode
SectionOriginal Article(s)
DOI https://doi.org/10.18502/ijpa.v16i4.7879
Lymphatic Filariasis Nigeria Knowledge Epidemiology Wuchereria bancrofti

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How to Cite
Aniaku IE, Onyishi GC, Nwosu C, Urama CC, Akobe NA, Nnawuihe OO, Obodo CS. Predisposing Factors to Lymphatic Filariasis among Residents in Igbo-Eze North; an Endemic Area in Nigeria. Iran J Parasitol. 2021;16(4):663-671.