Severe Cerebral Falciparum Malaria with Dengue Coinfection: A Case Report
AbstractA rare severe case of the coinfection of cerebral falciparum malaria and dengue is reported in this paper. The patient was a 50 yr old male in the north of China, who returned from Uganda not long ago and suffered unconsciousness after fever for 4 d before the falciparum malaria and dengue infection was diagnosed via blood smear microscopy, RT-PCR and serology, although the antimalarial and symptomatic treatment was carried out, ultimately the patients died of septic shock because of multiple organ dysfunctions. This case report showed such a coinfection was prone to cause severe acute consequence. The timely diagnosis and delicate treatment are crucial for prognosis of patients
World Health Organization. World Malaria Report 2015. http://apps.who.int/iris/bitstream/10665/200018/1/9789241565158_eng.pdf?ua=1
Khetarpal N, Khanna I. Dengue Fever: Causes, Complications, and Vaccine Strategies. J Immunol Res. 2016; 2016:6803098.
Charrel RN, Brouqui P, Foucault C, de Lamballerie X. Concurrent dengue and malaria. Emerg Infect Dis. 2005; 11(7):1153-4.
Yong KP, Tan BH, Low CY. Severe falciparum malaria with dengue coinfection complicated by rhabdomyolysis and acute kidney injury: an unusual case with myoglobinemia, myoglobinuria but normal serum creatine kinase. BMC Infect Dis. 2012; 12:364.
Zhang L, Zhou SS, Feng J et al. Malaria situation in the People’s Republic of China in 2014. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2015; 33(5):319-26.
Mu D, Li Y, Yin WW, Yu HJ. Analysis on the epidemiological characteristics of dengue fever in China. Int J Virol. 2016; 23(3):177-80.
Li LJ, Ren H. Infectious diseases. 8th ed. Beijing: People’s Medical Publishing House; 2013.
The editorial board of Practice of Internal Medicine in the first Medical College of Shanghai. Practice of Internal Medicine. 7th ed. Beijing: People's Medical Publishing House; 1980.
Epelboin L, Hanf M, Dussart P, Ouar-Epelboin S, Djossou F, Nacher M, Carme B. Is dengue and malaria co-infection more severe than single infections? A retrospective matched-pair study in French Guiana. Malar J. 2012; 11:142.
Shan ZQ, Yu XB. Progress in the research of malaria diagnosis. China Trop Med. 2001; 1(1):47-9.
White NJ, Ho M. The pathophysiology of malaria. Adv Parasitol. 1992; 31:83-173.
Dai Y, Pan ZW, Zhang ZY et al. Screening of infection of malaria parasite with atypical eosinophil distributions in the WBC scattergram and alarm in Sysmex XE-2100 hematology analyzer. Chin J Lab Med. 2008; 31(7):763-6.
|Issue||Vol 13 No 2 (2018)|
|Falciparum malaria Dengue Coinfection Prognosis|
|Rights and permissions|
|This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.|