Review Article

The Burden of Cystic Echinococcosis in Kenya: A Review Article

Abstract

Background: Cystic echinococcosis (CE), caused by the larval stage of Echinococcus granulosus sensu lato (s.l), is a zoonotic parasitic disease with a worldwide distribution. Kenya is one of the high endemic countries of CE with the endemic areas in the country being under immense occupation of traditional pastoralists. Turkana area in Kenya, has in the past recorded the highest prevalence of CE in the world.

Methods: The keywords cystic echinococcosis; Prevalence; Diagnosis; Risk-factors; Kenya were searched on google scholar and PubMed and the important literature materials retrieved for further analysis.

Results: The most notable infection risk factor for this disease in the country is the close association between man, dogs, and livestock. Successful control of CE in Kenya requires application of innovative interventions achieved after the review of the disease situation in the country. With the emergence and advent of new diagnostic techniques, CE organ-specific infections and transmission pattern in Kenya differ from what is commonly reported in literature.

Conclusion: A better understanding of CE prevalence of different hosts, its transmission pattern and the pathogenicity might make it possible to set up more effective control programs in future.

WHO Echinococcosis report 2016

Muller R. Worms and Human Diseases. 2nd Ed. Wallingord : CABI International, OXON, UK; 2002

Xiao N, Qiu J, Nakao M, Yang W, Chen X, Schantz PM, Craig PS, Ito A. Echinococcus Schiquicus a new species from the Qinghai-Tibet plateau region of China: discovery and epidemiological implications. Parasitol Int. 2006 (55):233-6

Odero JK. The burden of Cystic Echinococcosis in Kenya in selected regions of Kenya. Thesis submitted to Jommo Kenyatta University of Agriculture and Technology. 2015

Addy F, Alakonya A, Wamae N, Magambo J, Mbae C, Mulinge E, Zeyhle E, Wassermann M, Kern P and Romig T. Prevalence and Diversity of echinococcosis in livestock in Maasailand, Kenya. Parasitol Res 2012(111):2289-94

McManus DP and Thompson RC. Molecular epidemiology of Cystic Echinococcosis. Parasitology J. 2003 (127):S37-S51 DOI:10.1017/S0031182003003524

Casulli A, Zeyhle E, Brunetti E, Pozio E, Meroni V, Genco F and Filice C. Molecular evidence of the camel strain (G6) genotype of Echinococcus granulosus in human from Turkana, Kenya. Royal Society of Tropical Medicine and Hygien 2009 xxx-xxx

Dinkel A, Njoroge EM, Zimmermann A, Walz M, Zeyhle E, Elmahdi IE, Mackenstedt U and Romig T. A PCR system for detection of species and genotypes of the Echinococcus granulosus-complex, with reference to the epidemiological situation in eastern Africa. International J for Parasitology 2004 (34):645-53

Macpherson CN, Barthodomot B, and Frider B. Application of ultrasound in diagnosis, treatment, epidemiology, public health and control of Echinococcus granulosus and E. multilocularis. Parasitology 2003; 127, S21

Eckert J, Ghemmell MA, Meslin, F.-X and Powlowski, Z. S. WHO/OIE Manual on Echinococcosis in Humans and Animals: a Public Health Problem of Global Concern. ISBN 2002; (92):522-X

Solomon N, Zeyhle EC., Wchira J, Mengiste A, Romig T, Fields JP, Macpherson CN. Cystic Echinococcosis in Turkana, Kenya: The Role of Cross Sectional Screening Surveys in assessing the prevalence of human infection. American j of Trop Medicine and Hygiene 2017;(97):2

Huttner M, Siefert L, Mackenstedt U and Romig T. A Survey of Echinococcus species in wild carnivores and livestock in East Africa. International J for Parasitology (2009) (39):1269-76

Nelson GS. Hydatid Disease: Research and Control in Turkana, Kenya. 1. Epidemiological observation. Trans R Soc Trop Med Hyg. 1986 (80): 177-82

MacPherson CN, Karsad L, Stevenson P, and Arundel JH. Hydatid cyst in the Turkana District of Kenya. III. The significance of wild animals in the transmission of Echinococcus granulosus with particular reference to Turkana and Maasailand in Kenya. Ann Top Med Parasitology 1983;(77):61-73

Craig PS, Macpherson CN, Watson-Jones DL. and Nelson GL. Immunodetection of Echinococcus eggs from naturally infected dogs and from environmental contamination sites in settlement in Turkana, Kenya. Royal Society of Tropical Medicine and Hygiene 1988;(82):268-274

Juttner K, McKenzie L, Razzak N, Zehyle E, Belliere M, Anderson D and Tulloh R. Cardiac hydatid diseasein the third world. BMJ Case Reports 2011; doi 10.1136/bcr.12.2010.3609

Ndaguatha PL. Unusual bladder outflow obstruction: Case Report. East Africa Medical Journal 2003 doi:10.4314/eamj.v80i7.8725.source:Pubmed

Kuremu RT, Svanvik J, Bwombengi OS, Lelei LK, and Mathews D. Hydatid Disease of the Spine: Case Report. East African Medical J. 2002;(79) :165-166

Mulambalah CS & Siteti DI. Update on Human Bone Hydatid disease. Science Journal of Clinical Medicine 2015(4):10-17

Chana HS, Klauses V, Shah A. Orbital Hydatidosis in Kenya. Am J Trop Med Hyg. 1986;(35):991-4

Njoroge EM, Mbithi PM, Gathuma JM, Wachira TM, Gathura PB, Magambo JK, and Zeyhle E. A Study of Cystic Echinococcosis in slaughter animals in three selected areas of northern Turkana, Kenya. Veterinary Parasitology. 2002;(xx):10485-91

Kitelberger R, Reichel MP, Jenner J, Heath D, Lightowlers MW, Moro P, and O’Keefe JS. Evaluation of three enzyme-linked immunosorbent assays (ELISAs) for the detection of serum antibodies in sheep infected with Echinococcus granulosus. Veterinary Parasitolology. 2002;(110):57-76

Gathura, PB & Kamiya M. Echinococcosis in Kenya: transmission characteristics, incidence and control measures. Jpn J vet Res. 1990; (38):107-16

Abakar AD., El Mahdi IE., Mohammed AA and Malik AA., 2016. Status of Cystic-echinococcosis caused by Echinococcus granulosus in Sudan. Merit Research J of Medicine and Medical Sciences .2017;( 4):323-328

Okelo GB. Hydatid disease: research and control in Turkana, III. Albendazole in the treatment of inoperable hydatid disease in Kenya-a report in twelve cases. Trans R Soc Trop Med Hyg. 1986; (80):193-5. doi:10.1016/0035-9203(86)90005-2

Blanton RE, Wachira TM, Zeyhle EE, Njoroge EM, Magambo JK, Schantz PM. Oxfendazole treatment for cystic hydatid disease in naturally infected animals. Antimicrobiol agents and chemotherapy. 1998;(42):601-605

Eckert J, Deplazes P, Craig PS, Gemmell MA, Gottsten B, Heath D.…and Lightlowers, M. Echinococcosis in animals: Clinical aspects, diagnosis and treatment. International J (2001a ):72-99

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IssueVol 14 No 4 (2019) QRcode
SectionReview Article(s)
DOI https://doi.org/10.18502/ijpa.v14i4.2092
Keywords
Cystic echinococcosis Prevalence Diagnosis Risk-factors Kenya

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How to Cite
1.
KIA EB, OUMA FF, MULAMBALAH CS, OKOTH PK. The Burden of Cystic Echinococcosis in Kenya: A Review Article. Iran J Parasitol. 2019;14(4):502-509.