Determination of Trace Metals Abnormalities in Patients with Vivax Malaria
,
Abstract
Background: In the present study, blood serum level of metals were determined in malarial patients and compared with those in the normal subjects without complication using Atomic Absorption Spectrometer.
Methods: For the determination of these metals twelve intravenous blood samples each from referred malarial patients and a group of normal subjects were collected and immediately centrifuged to obtain the supernatant liquid, serum of both the groups for analysis.
Results: The blood serum levels of copper in malarial patients determined to be 2.6917 ppm, which is higher as compared to that found 2.045 in normal subjects. Whereas the blood serum levels of iron, magnesium, and zinc found 2.0708 ppm, 12.2467 ppm and 4.9017 ppm respectively in malarial patients, who are lower than those, are determined in the blood serum of normal subjects. Blood serum levels of iron, magnesium, and zinc in normal subjects found 3.950 ppm, 19.4892 ppm, and 5.242 ppm respectively.
Conclusion: In this study the metal content of copper, iron, magnesium and zinc in vary in malarial patients as compared those in the normal subjects. It may suggest that the decreased levels of iron, magnesium, and zinc can be maintained by giving as supplement of these metals in therapy.
Rosenthal PJ. Protease of malaria parasite. Emerging Infec Dis 1998, 4:49-57.
Sandstead HH, Lofgren PA. Dietary Zinc and Iron- Recent Perspectives Regarding Growth andCognitive Development. J Nutr. 2000;130 (2):345-346.
GulatiRB, SainaniGS.A.P.I.Text Book ofMedicine. 3rd ed. Bombay:1979.
Gouado Inocent, Lehman Leopold Gustave, Some Issa T, Mbouyap Yolonde, Pankoui Mfonkeu Joel Bertand, Ejoh Aba Richard, Tchouanguep Mbiapo Felicité. Influence of malaria on the serum levels of vitamin A, zinc and calcium of children in Douala-Cameroon.Afr J Biotechnol. 2007;6 (7):871-876.
Brown KH, Lanata CF, YuenML, Peerson JM, Butron B, Lönnerdal B. Potential magnitude of the misclassification of a population’s trace element status due to infection example from a survey of young Peruvian children.AmJ Clin Nutr. 1993;58 (4):549-554.
BeiselWR, Pekarek RS, Van Ormer D, Wannemacher RWJr. Influence of acute infection on the metabolism of zinc and other trace elements. Psychopharmacol. 1995; (7):34–35.
Platel DF, Mangou F, Tribouley-Duret J. Role of glutathione in the detoxification of erriprotoporphyrin IX in chloroquine resistant Plasmodium berghei. Mol Biochem Parasitol. 1999;98(2):215-23.
Majumdar I, Paul P, Talib VH,Ranga S. The effect of iron therapy on the growth of iron-replete and iron-deplete children. JTrop Pediatr.2003;49 (2):84-88.
Scrimshaw NS. Minerals and immunity. AnnN.YAcad. Sci. N.Y: 1990.
Kawano Y, Abe H, Kojima S, Yoshimi H,Sanai T, Kimura G, Matsuoka H, Takishita S, Omae T. Effects of magnesium supplementation in hypertensive patients. Hypertension. 1998; (32): 260-265.
Wester PO. Magnesium. Am J Clin Nutr. 1987;45(5 Suppl): 1305-12.
Ray AP, Narasimham MVVL, Kalra N L. Indian Society for malaria, and other communicable diseases. New Delhi: 1992. Available from: http://www.malariasite.com/ref.htm.
Adnan Seyrek, Abdurrahim Kocyigit, OzcanErel. Essential trace elements selenium, zinc, copper, and iron concentrations and their related acute-phase proteins in patients with vivax malaria. Biol TraceElemRes. 2005;106(2): 107-115.
1Garba IH, Ubom GA. Potential role of serum magnesium measurement as a biomarker of acute falciparum malaria infection in adult patients. Biol Trace ElemRes.2006;114 (1-3): 115-120.
Maurois P, Gueux. E, Rayssiguier Y. Magnesium deficiencyaffects malaria susceptibility in mice. J Am Coll Nutr. 1993;1 (12): 21-25.
| Files | ||
| Issue | Vol 6 No 2 (2011) | |
| Section | Articles | |
| Keywords | ||
| Malaria Serum Trace Metals Atomic Absorption Spectrometer | ||
| Rights and permissions | |
|
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
