Epidemiology of Hookworm Infection in the School-age Children: A Comparative Cross-sectional Study
Abstract
Background: Globally more than 740 million peoples are infected with hookworm. In sub-Saharan Africa, approximately 200 million people have been infected with hookworm, 90 million of them were children. The objective of this study was to identify the prevalence and determinant factors of hookworm infection in urban and rural school-age children’s.
Methods: This comparative cross-sectional study design was conducted in Bahir Dar and Mecha district, Bahir Dar, Ethiopia from Mar-May, 2014. Epi-info software was used to calculate the sample size. Multistage sampling technique was used to select the children’s. Blood and stool samples were collected from the children to determine the hemoglobin level and the presence of parasites. Data were entered into the computer using Epi-info software and transferred to SPSS for analysis. Descriptive statistics were used to identify the prevalence of hookworm and binary logistic regression was used to identify the determining factors for hookworm.
Results: The prevalence of hookworm was 22.3% [21%-24%]. Hookworm infection was associated with gender (AOR 1.31, 95% CI [1.03-1.66]), wearing shoe (AOR 0.35, 95% CI [0.25-0.48]), hand washing practice (AOR 0.62, 95% CI [0.48-0.79]), personal hygiene (AOR 0.45, 95% CI [0.34-0.61]), age (AOR 0.44, 95% CI [0.34-0.57]) or availability of latrine (AOR 0.08, 95 % CI [0.06-0.1]). Hookworm infection significantly decreases the school performance of children.
Conclusion: High prevalence of hookworm infection was observed. The ministry of health and ministry of education should include deworming activity as one strategy to increase quality of education.
References
Ranjit N, Zhan B, Hamilton B, Stenzel D, Lowther J, Pearson M. Proteolytic Degradation of Hemoglobin in the Intestine of the Human Hookworm. Necator americanus. J Infect Dis. 2009;199(6):904-12.
Pearson M, Pickering D, Tribolet L, Cooper L, Mulvenna J, Oliveira L. Neutralizing Antibodies to the Hookworm Hemoglobinase Na-APR-1: Implications for a Multivalent Vaccine against Hookworm Infection and Schistosomiasis. J Infect Dis. 2010;201(10):1561-9.
Hotez P, Bethony J, Diemert D, Pearson M, Loukas A. Developing vaccines to combat hookworm infection and intestinal schistosomiasis. Opportunities for Integrated Intervention Strategies. Washington (DC). United States of America Institute of Medicine (US) Forum on Microbial Threats; 2011.
Midzi N, Mtapuri S, Mapingure M, Sangweme D, Chirehwa M, Brouwer K. Consequences of polyparasitism on anaemia among primary school children in Zimbabwe Acta Tropica. 2010;115(1-2):103-11.
Ngui R, Lim Y, Chong L, Sek C, Jaffar S. Association between Anaemia, Iron Deficiency Anaemia, Neglected Parasitic Infections and Socioeconomic Factors in Rural Children of West Malaysia. . PLoS Negl Trop Dis. 2012;6(3):1-8.
WIKIPEDIA. Hook worm: wikipedia; 2013 [Available from: http://en.wikipedia.org/wiki/Hookworm.
Albonico M, Stoltzfus R, Savioli L, Tielsch J, Chwaya H. Epidemiological evidence for a differential effect of hookworm species, ancylostoma duodenale or necator americanus, on iron status of children. Int J Epidemiol. 1998;27(3):530-7.
Fekadu D, Petros B, Kebede A. Hookworm species distribution among school children in Asendabo Town, Jimma Zone, Southwest Ethiopia. Ethiop J Health Sci. 2008;18(2):53-6.
Peter H, David M, Alan F, Eric O, Sonia S, Jeffrey S. Incorporating a Rapid-Impact Package for Neglected Tropical Diseases with Programs for HIV/AIDS, Tuberculosis, and Malaria. PLoS Med 2006;3(5):576-84.
Jeremiah N, Carol A, Yulya S, Kacie M. Social and Economic Impact Review on Neglected Tropical Diseases. Washington DC: HUdson Institute 2012. 36 p.
Hotez P. The development impact of the neglected tropical diseases United Nations Department of Economic and Social Affairs Population Division; 2011. p. 1-40.
Brooker S. Estimating the global distribution and disease burden of intestinal nematode infections. Int J Parasitol. 2010;40(10):1137-44.
Robertson L, Crompton D, Sanjur D, Nesheim M. Haemoglobin concentrations and concomitant infections of hookworm and Trichuris trichiura in Panamanian primary school children. Trans R Soc Trop Med Hyg. 1992;86:654-6.
Seshadri S, Gopaldas T. Impact of iron supplementation on cognitive functions in preschool and school-aged children: the Indian experience. Am J Clin Nutr. 1989;50:675-86.
Fred S, Alina S, Neci S. HOOKWORM AND THREADWORM INFECTIONS AND THEIR ASSOCIATION WITH HEMOGLOBIN AND EOSINOPHIL CONCENTRATIONS IN RESIDENTS OF SALVADOR-BAHIA, BRAZIL. Rev Inst Med Trop Sao Paulo. 2013;55(4):233-8.
Hoyt B. Disease and Development: Evidence from Hookworm Eradication in the American South. The Quarterly Journal of Economics. 2007.
Nokes C, Cooper E, Robinson B, Budy D. Geohelminth infection and academic assessment in Jamaican children. . Trans Roy Soc Trop Med Hyg. 1991;85:272-3.
Nokes C, Bundy D. Does helminth infection affect mental processing and educational achievement? . Parasitol Today. 1994;10:14-8.
Nokes C, Grantham S, Sawyer A, Cooper E, Bundy D. Parasitic helminth infection and cognitive function in schoolchildren. Proceed Roy Soc London B 1992;247:77-81.
Stephenson L, Latham M, Kurz K, Kinoti S, Brigham H. Treatment with a single dose of albendazole improves growth of Kenyan school children with hookworm, Trichuris trichiura, and Ascaris lumbericoides infections. . Am J Trop Med Hyg. 1989;4:78-87.
Stansfield S, Bundy D, Mitchell A, Bhatia R, Engels D, Montresor A, et al. Schistosomiasis and soil-transmitted helminth infections: forging control efforts. Trans R Soc Trop Med Hyg. 2002;96(6):577-9.
WHO. Control of neurocysticercosis: report by the Secretariat, provisional agenda item 14.2, 56th World Health Assembly. Geneva; 2012.
Stephenson L. Optimizing the benefits of anthelmintic treatment in children. Paediatr Drugs. 2001;3(7):495-508.
Hotez P, Fenwick A, Savioli L. Rescuing the bottom billion through control of neglected tropical diseases. Lancet. 2009;373:1570-75.
Silva N, Brooker S, Hotez P, Montresor A, Engels D, Savioli L. Soil-transmitted helminth infections: updating the global picture Trends Parasitol. 2003;19:547 - 51.
Bethony J, Brooker S, Albonico M, Geiger S, Loukas A, Diemert D, et al. Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm Lancet. 2006;367:1521 - 32.
Yelifari L, Bloch P, Magnussen P, Lieshout L, Dery G, Anemana S, et al. Distribution of humanOesophagostomum bifurcum , hookworm andStrongyloides stercoralis infections in northern Ghana Trans R Soc Trop Med Hyg. 2005;99:32 - 8.
Silva N, Brooker S, Hotez P, Montresor A, Engels D. Soil transmitted helminth infections: updating the global picture. Trends Parasitol. 2003;19(12):547-51.
Hall A, Suvenchan M. Intestinal Worms: Strategies to Control Disease, African Health. 1994;17(23).
Janice V, Vicente B, Florencia C. Determination of soil-transmitted helminth infection and its association with hemoglobin levels among Aeta schoolchildren of Katutubo Village in Planas, Porac, Pampanga. Philippine Science Letters. 2014;7(1):73-80.
Debbie H, Emily M, Joseph O, Welbeck A, Lauren W, Hinckley J, et al. Epidemiology of Hookworm Infection in Kintampo North Municipality, Ghana: Patterns of Malaria Coinfection, Anemia, and Albendazole Treatment Failure. Am J Trop Med Hyg. 2011;84(5):792-800.
Hotez P, Fenwick A, Savioli L, Molyneux D. Rescuing the “bottom billion” through neglected tropical disease control. Lancet. 2009;373:1570-6.
Hotez P, Brindley P, Bethony J, King C, Pearce E, Jacobson J. Helminth infections: the great neglected tropical diseases. J Clin invest. 2008;118:1311-21.
Benoist B, McLean E, Egli I, Cogswell M. Worldwide prevalence of anaemia 1993–2005. In: Organization WH, editor. 2008.
Simon B, Peter H, Donald B. H o o k w o r m - R e l a t e d A n a e m i a a m o n g P r e g n a n t W o m e n : A Syste matic Review. PLoS Negl Trop Dis 2008;2(9):1-9.
Brooker S, Clements A, Bundy D. Global epidemiology, ecology and control of soil transmitted helminth infections. Adv Parasitol. 2006;62:221-61.
Molyneux D, Hotez P, Fenwick A. ‘‘Rapid-impact interventions’’: how a policy of integrated control for Africa’s neglected tropical diseases could benefit the poor. PLoS Med. 2005;2(11).
Brooker S, Clements A, Bundy D. Global epidemiology, ecology and control of soil-transmitted helminth infections Adv Parasitol. 2006;62:221-61.
Simon B, Archie C, Peter H, Simon H, Andrew T, Donald B, et al. The co-distribution of Plasmodium falciparum and hookworm among African schoolchildren. Malaria Journal. 2006;5(99).
Peter H, Aruna K. Negl ected Tropi cal Diseases in Sub-Sa haran Africa: Review of Their Prevalence, Distribu tion, and Disease Burden. PLoS Negl Trop Dis 2009;3(8):1-6.
Tadesse Z, Hailemariam A, Kolaczinski J. Potential for integrated control of neglected tropical diseases in Ethiopia. Trans R Soc Trop Med Hyg. 2008;2008(102):213-4.
Girum T. The prevalence of intestinal helminthic infections and associated risk factors among school children in Babile town, eastern Ethiopia. EthiopJHealth Dev. 2005;19(2):140-7.
ALEMESHET Y, YOSEPH M, SELESHI K. PREVALENCE AND PREDICTORS OF INTESTINAL HELMINTHIASIS AMONG SCHOOL CHILDREN IN JIMMA ZONE; A CROSS-SECTIONAL STUDY. Ethiop J Health Sci. 2011;21(3):167-73.
Amare M, Solomon S, Tesfaye K. Prevalence of intestinal parasitic infections among urban dwellers in southwest Ethiopia. EthiopJHealth Dev. 2007;21(1):12-7.
Wondimagegnehu T, Woldemichael T, Assefa T. Hookworm infection among the Melka Sedi banana plantation residents, middle Awash Valley, Ethiopia. Ethiop Med J. 1992;30(3):129-34.
Megbaru A, Asrat H, Gessessew B. Prevalence of intestinal schistosomiasis and soil transmitted helminthiasis among primary school children in Umolante district, South Ethiopia. Clinical Medicine Research. 2014 3(6):174-80.
Mengistu L, Berhanu E. Prevalence of intestinal parasites among schoolchildren in a rural area close to the southeast of Lake Langano, Ethiopia. EthiopJHealth Dev 2004;18(2):116-20.
Lopiso E, Yared M, Ayele A, Mohammed A, Ashenafi B, Sultan M, et al. Prevalence of Hookworm infection and hemoglobin status among rural elementary school children in Southern Ethiopia. Ethiop J Health Dev. 2002;16(1):113-5.
Bemnet A, Jemal A, Beyene M, Gizachew Y, Yeshambel B, Simon G, et al. Nutritional status, intestinal parasite infection and allergy among school children in Northwest Ethiopia. BMC Pediatrics 2013;13(7):1-9.
Mengistu E, Wossenseged L, Yeshambel B, Beyene M, Aschalew G, Belay A, et al. PREVALENCE OF INTESTINAL PARASITES AND ASSOCIATED RISK FACTORS AMONG STUDENTS OF ATSE FASIL GENERAL ELEMENTARY SCHOOL AZEZO, NORTHWEST ETHIOPIA. Ethiop J Health Biomed Sci. 2010;3(1).
Alemu A, Atnafu A, Addis Z, Shiferaw Y, Teklu T, Mathewos B, et al. Soil transmitted helminths and schistosoma mansoni infections among school children in Zarima town, northwest Ethiopia. BMC Infect Dis 2011;9(11):189.
Lemlem L, Berhanu E, Asrat H. Current status of intestinal Schistosomiasis and soiltransmitted helminthiasis among primary school children in Adwa Town, Northern Ethiopia. Ethiop J Health Dev. 2010;24(3):191 -7.
Williams W, Eric N, Ezekiel K, Samuel C. Prevalence of hookworm infection: A retrospective study in Kumasi, Ghana. Science Journal of Public Health. 2014;2(3):196-9.
Yeshambel B, Girmay M, Alemayehu A, Berhanu E, Charlotte H, Atalay A, et al. Prevalence and risk factors for soil-transmitted helminth infection in mothers and their infants in Butajira, Ethiopia: a population based study. BMC Public Health 2010;10:21.
Kram M, Juanita H, Saeed A, Ghazala R, Mohammad A. Prevalence and Factors Associ ated with Intestinal P a r a s i t i c I n f e c t i o n a m o n g C h i l d r e n i n a n U r b a n S l u m o f K a r a c h i. PLoS ONE. 2008;3(11):1-6.
Brooker S, Clements A, Bundy D. Global epidemiology, ecology and control of soil-transmitted helminth infections. Adv Parasitol. 2006;62:221-61.
Bethony J, Brooker S, Albonico M, Geiger S, Loukas A, Diemert D, et al. Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm. The Lancet 2006;67(9521):1521-32.
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| Issue | Vol 13 No 4 (2018) | |
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