Evaluating Effect of Albendazole on Trichuris trichiura Infection: A Systematic Review Article
-
Toraj AHMADI JOUYBARI
,
Khadije NAJAF GHOBADI
,
Bahare LOTFI
,
Hamid ALAVI MAJD
,
Nayeb Ali AHMADI
,
Mohammad ROSTAMI-NEJAD
,
Abbas AGHAEI
Abstract
Background: The aim of the study was assessment of defaults and conducted meta-analysis of the efficacy of single-dose oral albendazole against T. trichiura infection.
Methods: We searched PubMed, ISI Web of Science, Science Direct, the Cochrane Central Register of Controlled Trials, and WHO library databases between 1983 and 2014. Data from 13 clinical trial articles were used. Each article was included the effect of single oral dose (400 mg) albendazole and placebo in treating two groups of patients with T. trichiura infection. For both groups in each article, sample size, the number of those with T. trichiura infection, and the number of those recovered following the intake of albendazole were identified and recorded. The relative risk and variance were computed. Funnel plot, Beggs and Eggers tests were used for assessment of publication bias. The random effect variance shift outlier model and likelihood ratio test were applied for detecting outliers. In order to detect influence, DFFITS values, Cook’s distances and COVRATIO were used. Data were analyzed using STATA and R software
Results: The article number 13 and 9 were outlier and influence, respectively. Outlier is diagnosed by variance shift of target study in inferential method and by RR value in graphical method. Funnel plot and Beggs test did not show the publication bias (P=0.272). However, the Eggers test confirmed it (P=0.034). Meta-analysis after removal of article 13 showed that relative risk was 1.99 (CI 95% 1.71 - 2.31).
Conclusion: The estimated RR and our meta-analyses show that treatment of T. trichiura with single oral doses of albendazole is unsatisfactory. New anthelminthics are urgently needed.Cooper H, Hedges LV, Valentine JC. The handbook of research synthesis and meta-analysis. 2nd ed. New York: Russel Sage Foundation; 2009.
Sterne JA, Jüni P, Schulz KF, Altman DG, Bartlett C, Egger M. Statistical methods for assessing the influence of study characteristics on treatment effects in ‘meta-epidemiological’ research. Stat Med. 2002; 21(11):1513-24.
WHO. Preventive chemotherapy in human helminthiasis: Coordinated use of antihelmintic drugs in control interventions. A manual for health professionals and programme managers. Geneva: World Health Organization; 2006. p. 1–62.
Bethony J, Brooker S, Albonico M, Geiger SM, Loukas A, Diemert D, et al. Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm. Lancet. 2006;367(9521):1521-32.
Brooker S. Estimating the global distribution and disease burden of intestinal nematode infections: adding up the numbers–a review. Int J Parasitol. 2010;40(10):1137-44.
Pullan RL, Smith JL, Jasrasaria R, Brooker SJ. Global numbers of infection and disease burden of soil transmitted helminth infections in 2010. Parasit Vectors. 2014;7(1):1.
Brooker S, Clements AC, Bundy DA. Global epidemiology, ecology and control of soil-transmitted helminth infections. Adv Parasitol. 2006;62:221-61.
Zimmermann MB, Hurrell RF. Nutritional iron deficiency. Lancet. 2007;370(9586):511-20.
Smits HL. Prospects for the control of neglected tropical diseases by mass drug administration. Expert Rev Anti Infect Ther. 2009;7(1):37-56.
Keiser J, Utzinger J. Efficacy of current drugs against soil-transmitted helminth infections: systematic review and meta-analysis. JAMA. 2008;299(16):1937-48.
Oyediran ABOO, Oyejide CO. Double-blind comparative study of a new anthelminthic, albendazole, in the treatment of intestinal helminthes. In: Firth M, editor. Albendazole in Helminthiasis: Royal Society of Medicine International Congress and Symposium Series No. 57. London, England: Royal Society of Medicine;1983. P. 69-81.
Bwibo NO, Pamba HO. Double-blind comparative study of albendazole and placebo in the treatment of intestinal helminths. In: Firth M, ed. Albendazole in Helminthiasis: Royal Society of Medicine International Congress and Symposium Series No. 61. London, England: Royal Society of Medicine; 1984. P. 47-53.
Ovedoff DL. Summary of albendazole trials in South-East Asia. In: Firth M, ed. Albendazole in Helminthiasis: Royal Society of Medicine International Congress and Symposium Series No. 61. London, England: Royal Society of Medicine; 1984. P.103-112.
Chien F, Foon K, Hassan K. Efficacy of albendazole against the three common soil-transmitted helminthiases. Trop Biomed. 1989;6:133-6.
Upatham E, Viyanant V, Brockelman W, Kurathong S, Lee P, Chindaphol U. Prevalence, incidence, intensity and associated morbidity of intestinal helminths in south Thailand. Int J Parasitol. 1989;19(2):217-28.
Sinniah B, Chew P, Subramaniam K. A comparative trial of albendazole, mebendazole, pyrantel pamoate and oxantel pyrantel pamoate against soil-transmitted helminthiases in school children. Trop Biomed. 1990;7(2):129-34.
Stephenson LS, Latham MC, Kinoti SN, Kurz KM, Brigham H. Improvements in physical fitness of Kenyan schoolboys infected with hookworm, Trichuris trichiura and Ascaris lumbricoides following a single dose of albendazole. Trans R Soc Trop Med Hyg. 1990;84(2):277-82.
Beach MJ, Streit TG, Addiss DG, Prospere R, Roberts JM, Lammie PJ. Assessment of combined ivermectin and albendazole for treatment of intestinal helminth and Wuchereria bancrofti infections in Haitian schoolchildren. Am J Trop Med Hyg. 1999;60(3):479-86.
Olds G, King C, Hewlett J, Olveda R, Wu G, Ouma J, et al. Double-blind placebo-controlled study of concurrent administration of albendazole and praziquantel in schoolchildren with schistosomiasis and geohelminths. J Infect Dis. 1999;179(4):996-1003.
Ndibazza J, Muhangi L, Akishule D, Kiggundu M, Ameke C, Oweka J, et al. Effects of deworming during pregnancy on maternal and perinatal outcomes in Entebbe, Uganda: a randomized controlled trial. Clin Infect Dis. 2010;50(4):531-40.
Speich B, Ame SM, Ali SM, Alles R, Hattendorf J, Utzinger J, et al. Efficacy and safety of nitazoxanide, albendazole, and nitazoxanide-albendazole against Trichuris trichiura infection: a randomized controlled trial. PLoS Negl Trop Dis. 2012;6(6):e1685.
Wiria AE, Hamid F, Wammes LJ, Kaisar MM, May L, Prasetyani MA, et al. The effect of three-monthly albendazole treatment on malarial parasitemia and allergy: a household-based cluster-randomized, double-blind, placebo-controlled trial. PLoS One. 2013;8(3):e57899.
Yap P, Du Z-W, Wu F-W, Jiang J-Y, Chen R, Zhou X-N, et al. Rapid re-infection with soil-transmitted helminths after triple-dose albendazole treatment of school-aged children in Yunnan, People's Republic of China. Am J Trop Med Hyg. 2013;89(1):23-31.
Viechtbauer W, Cheung MWL. Outlier and influence diagnostics for meta‐analysis. Res Synth Methods. 2010;1(2):112-25.
Gumedze FN, Jackson D. A random effects variance shift model for detecting and accommodating outliers in meta-analysis. BMC Med Res Methodol. 2011;11(1):19.
Viechtbauer W. Conducting meta-analyses in R with the metafor package. J Stat Softw. 2010;36(3):1-48.
Alavi Majd H, Najafi Ghobadi KH, Ah-madi N, Nazari A. Application of effective diagnostic methods for meta-analyzing the effect of Albendazole in the treatment of patients with Hookworm. J Ilam Univ Med Sci. 2013;21(5):141–9.
Majd HA, Ghobadi KN, Baghban AA, Ahmadi N, Sajjadi E. Detecting and Accommodating Outliers in Meta-Analysis for Evaluating Effect of Albendazole on Ascaris lumbricoides Infection. Iran Red Crescent Med J. 2014;16(5): e17648.
Kaminsky R, Ducray P, Jung M, Clover R, Rufener L, Bouvier J, et al. A new class of anthelmintics effective against drug-resistant nematodes. Nature. 2008;452(7184):176-80.
| Files | ||
| Issue | Vol 11 No 4 (2016) | |
| Section | Review Article(s) | |
| Keywords | ||
| Meta-analysis Albendazole Trichuris trichiura | ||
| Rights and permissions | |
|
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
