Efficacy of the Bunium persicum (Boiss) Essential Oil against Acute Toxoplasmosis in Mice Model

  • Amir TAVAKOLI KARESHK Dept. of Medical Parasitology and Mycology, Kerman University of Medical Sciences, Kerman, Iran
  • Amir KEYHANI Dept. of Medical Parasitology and Mycology, Kerman University of Medical Sciences, Kerman, Iran
  • Hossein MAHMOUDVAND Research Center for Tropical and Infectious Diseases, Kerman University of Medical Science, Kerman, Iran
  • Razieh TAVAKOLI OLIAEI Dept. of Medical Parasitology and Mycology, Kerman University of Medical Sciences, Kerman, Iran
  • Arash asadi Dept. of Medical Parasitology and Mycology, Kerman University of Medical Sciences, Kerman, Iran
  • Moazameh ANDISHMAND Dept. of Medical Parasitology and Mycology, Kerman University of Medical Sciences, Kerman, Iran
  • Hossein AZZIZIAN Department of Physiology, Kerman University of Medical Sciences, Kerman, Iran
  • Zahra BABAEI Dept. of Medical Parasitology and Mycology, Kerman University of Medical Sciences, Kerman, Iran
  • Naser ZIA-ALI Dept. of Medical Parasitology and Mycology, Kerman University of Medical Sciences, Kerman, Iran
Keywords: Toxoplasma gondii, Bunium persicum Boiss, Prophylactic, Therapeutic

Abstract

Background: We evaluated the in vivo activity of Bunium persicum (Boiss) essential oil on infected mice with acute toxoplasmosis.Methods: To evaluate prophylactic effects, male NMRI mice received B. persicum essential oil at the concentrations of 0.05 and 0.1 mL/kg for 14 days. After 24 h mice were infected intraperitonealy with 1×104 tachyzoites of T. gondii, RH strain. In order to investigate therapeutic effects, mice were infected and then received B. persicum oil at the concentrations of 0.05 and 0.1 ml/kg two times a day for 5 days. The time/mean time of death in all infected mice and the number of tachyzoites from infected mice were recorded.Results: The time/mean time of death of infected mice was 8 and 9 days after oral administration of B. persicum oil at the concentration of 0.05 and 0.1 mL/kg, respectively (P<0.05). In contrast, the time/mean time of death control group was 5 days. In addition, B. persicum significantly reduced the mean number of tachyzo­ites compared with control group. The time/mean time of death of infected mice was 6 and 7 days after oral administration of B. persicum essential oil at the concentra­tion of 0.05 and 0.1 mL/kg, respectively. In contrast, the time/mean time of death control group was 5 days. B. persicum especially at the concentration of 0.1 ml/kg significantly reduced the mean number of tachyzoites compared with con­trol group. Conclusion: The results showed the potential of B. persicum essential oil as a natu­ral source for the production of new prophylactic agent for use in toxoplasmosis.

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Published
2015-12-14
How to Cite
1.
TAVAKOLI KARESHK A, KEYHANI A, MAHMOUDVAND H, TAVAKOLI OLIAEI R, asadi A, ANDISHMAND M, AZZIZIAN H, BABAEI Z, ZIA-ALI N. Efficacy of the Bunium persicum (Boiss) Essential Oil against Acute Toxoplasmosis in Mice Model. IJPA. 10(4):625-31.
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Original Article(s)