High Seroprevalence of Toxoplasma gondii Antibody in HIV/AIDS Individuals from North of Iran
AbstractBackground: Toxoplasmosis in immunocompetent people is generally asymptomatic but in immunocompromised patients including HIV/AIDS, cancer patients, and organ transplant recipients, etc. it can lead to serious pathological problems. The objective of current study was to determine the seroprevalence of T. gondii IgG and IgM antibodies in HIV/AIDS patients using ELISA technique in Mazandaran Province, northern Iran.Methods: Overall, 82 serum samples (61 males and 21 females) were collected from HIV/AIDS patients in Mazandaran Provinces, in 2013. Sera were surveyed employing ELISA assay. Data were analyzed using Chi-Square or Fisher exact test. In addition, before sampling a questionnaire was filled out for each subject.Results: Overall seroprevalence of examined sera was 96.3% for IgG antibody but none of the sera shown IgM antibody against T. gondii. The seroprevalence of toxoplasmosis in males and females was 96.7% and 95.2%, respectively. An antibody titer of >1 IU/ml was considered as positive. Furthermore, none of the included variables statistically was significant.Conclusions: Seroprevalence of chronic (latent) toxoplasmosis in HIV/AIDS patients in Mazandaran Province is high compared to toxoplasmosis in general population. Consequently, the risk of acquiring Toxoplasma encephalitis in examined seropositive HIV/AIDS patients of Toxoplasma is high.
Tenter AM. Toxoplasma gondii in animals used for human consumption. Memórias do Instituto Oswaldo Cruz. 2009; 104(2): 364-9.
Dubey J, Beattie C. Toxoplasmosis of animals and man: CRC Press, Inc.; 1988.
Jacquier P, Hohlfeld P, Vorkauf H, Zuber P. Epidemiology of toxoplasmosis in Switzerland: national study of seroprevalence monitored in pregnant women 1990-1991. Schweiz Med Wochenschr Suppl. 1994;65:29S-38S.
Sarvi S, Daryani A, Aarabi M, Mizani A, Ahmadpour E, Shokri A, Rahimi, MT, Sharif M. Seroprevalence of Toxoplasma gondii in Iran general population: A systematic Review and Meta-analysis. submitted to. Acta Trop. 2014; 137: 185-194.
Dubey J, Jones J. Toxoplasma gondii infection in humans and animals in the United States. Int J Parasitol. 2008; 38(11): 1257-78.
Jones JL, Kruszon-Moran D, Wilson M, McQuillan G, Navin T, McAuley JB. Toxoplasma gondii infection in the United States: seroprevalence and risk factors. Am J Epidmiol. 2001; 154(4): 357-65.
Tekkesin N. Diagnosis of toxoplasmosis in pregnancy: a review. HOAJ Biology. 2012; 1(1): 9.
Youssefi MR, Mousapour A, Nikzad R, Gonzalez-Solis D, Halajian A, Rahimi MT. Gastrointestinal helminths of the Caspian turtle, Mauremys caspica (Testudines), from Northern Iran J Parasitic Dis.1-4.
Daryani A, Sharif M, Meigouni M. Seroprevale-nce of IgG and IgM antiToxoplasma antibodies in HIV/AIDS patients, northern Iran. Asian Pacific J Trop Med. 2011; 4(4): 271-4.
Mohraz M, Mehrkhani F, Jam S, SeyedAlinaghi SA, Sabzvari D, Fattahi F. Seroprevalence of Toxoplasmosis in HIV+/AIDS Patients in Iran. Acta Med Iran. 2011; 49(4): 213-8.
Shafiei R, Riazi Z, Sarvghad M, Sharifdini MG, Mahmoodzadeh A, Hajia M. Prevalence of IgG and IgM anti-Toxoplasma gondii antibodies in HIV positive patients in northeast of Iran. Iran J Pathol. 2011; 6(2): 68-72.
Davarpanah M, Mehrabani D, Neirami R, Ghahremanpoori M, Darvishi M. Tox-oplasmosis in HIV/AIDS patients in Shiraz, southern Iran. Iran Red Cres Med J. 2007; 9(1): 22-7.
Afrasiabian S, Hajibagheri K, Yousefinejad V, Rezaiee S, Shahmoradi F. The frequency of Toxoplasma and Cytomegalovirus infections in HIV-positive patients in HIV/AIDS counseling and care center in Kurdistan in 1385. Sci J Kurdistan Uni Med Sci. 2008; 13(2): 34-41.
Falusi O, French AL, Seaberg EC, Tien PC, Watts DH, Minkoff H. Prevalence and predictors of Toxoplasma seropositivity in women with and at risk for human immunodeficiency virus infection. Clin Infect Dis. 2002; 35(11): 1414-7.
Grant IH, Gold JW, Rosenblum M, Niedzwiecki D, Armstrong D. Toxoplasma gondii serology in HIV-infected patients: the development of central nervous system toxoplasmosis in AIDS. AIDS. 1990;4(6): 519-22.
Pauwels A, Meyohas M, Eliaszewicz M, Legendre C, Mougeot G, Frottier J. Toxoplasma colitis in the acquired immunodeficiency syndrome. Am J Gastro. 1992; 87(4): 518-9.
Holliman R. Serological study of the prevalence of toxoplasmosis in asymptomatic patients
infected with human immunodeficiency virus. Epidemiol Infec. 1990; 105(02): 415-8.
Peterson PK, Gekker G, Hu S, Chao CC. Intracellular survival and multiplication of Toxoplasma gondii in astrocytes. J Infect Dis. 1993; 168(6): 1472-8.
Porter SB, Sande MA. Toxoplasmosis of the central nervous system in the acquired immunodeficiency syndrome. N Engl J Med. 1992; 327(23): 1643-8.
Contini C. Clinical and diagnostic management of toxoplasmosis in the immunocompromised patient. Parassitologia. 2008; 50(1/2): 45.
Ogoina D, Onyemelukwe GC, Musa BO, Obiako RO. Seroprevalence of IgM and IgG Antibodies to Toxoplasma infection in healthy and HIV-positive adults from Northern Nigeria. J Infec Developing Countries. 2013; 7(05): 398-403.
Saadatnia G, Golkar M. A review on human toxoplasmosis. Scandinavian J Infec Dis. 2012; 44(11): 805-14.