High Seroprevalence of Toxoplasma gondii Antibody in HIV/AIDS Individuals from North of Iran

  • Mohammad Taghi RAHIMI Toxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari, Iran
  • Seif Ali MAHDAVI Amol faculty of Paramedics, Mazandaran University of Medical Sciences, Sari, Iran
  • Behzad JAVADIAN Amol faculty of Paramedics, Mazandaran University of Medical Sciences, Sari, Iran
  • Rozita RE¬ZAEI Amol Faculty of Nursing and Midwifery, Mazandaran University of Medical Sciences, Sari, Iran
  • Mahmood MOOSAZADEH Health Sciences Research Center, School of Health, Mazandaran University of Medical Sciences, Sari, Iran
  • Mehri KHADEMLOU Health Center Province, Mazandaran University of Medical Sciences, Sari, Iran
  • Seyed Hosein SEYEDPOUR Health Center Province, Mazandaran University of Medical Sciences, Sari, Iran
  • Abolghasem SYADATPANAH Dep. of Medical Parasitology and Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
Keywords: Toxoplasma gondii, HIV/AIDS, Seroprevalence, Iran

Abstract

Background: Toxoplasmosis in immunocompetent people is generally asympto­matic but in immunocompromised patients including HIV/AIDS, can­cer pa­tients, and organ transplant recipients, etc. it can lead to serious pathological problems. The objective of current study was to determine the seroprevalence of T. gondii IgG and IgM antibodies in HIV/AIDS patients using ELISA technique in Mazanda­ran Province, northern Iran.Methods: Overall, 82 serum samples (61 males and 21 females) were collected from HIV/AIDS patients in Mazandaran Provinces, in 2013. Sera were surveyed employing ELISA assay. Data were analyzed using Chi-Square or Fisher exact test. In addition, before sampling a questionnaire was filled out for each subject.Results: Overall seroprevalence of examined sera was 96.3% for IgG antibody but none of the sera shown IgM antibody against T. gondii. The seroprevalence of toxoplasmosis in males and females was 96.7% and 95.2%, respectively. An antibody titer of >1 IU/ml was considered as positive. Furthermore, none of the included variables statistically was significant.Conclusions: Seroprevalence of chronic (latent) toxoplasmosis in HIV/AIDS patients in Mazandaran Province is high compared to toxoplasmosis in general population. Consequently, the risk of acquiring Toxoplasma encephalitis in exam­ined seropositive HIV/AIDS patients of Toxoplasma is high.

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Published
2015-12-14
How to Cite
1.
RAHIMI MT, MAHDAVI SA, JAVADIAN B, RE¬ZAEIR, MOOSAZADEH M, KHADEMLOU M, SEYEDPOUR SH, SYADATPANAH A. High Seroprevalence of Toxoplasma gondii Antibody in HIV/AIDS Individuals from North of Iran. IJPA. 10(4):584-9.
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