Effects of Toxoplasma gondii Infection in Level of Serum Testosterone in Males with Chronic Toxoplasmosis.

  • Zahra Eslamirad Department of Parasitology, School of Medicine, Arak University of Medical Sciences, Arak, Iran.
  • Reza Hajihossein Department of Parasitology, School of Medicine, Arak University of Medical Sciences, Arak, Iran.
  • Behzad Ghorbanzadeh Department of Parasitology, School of Medicine, Arak University of Medical Sciences, Arak, Iran.
  • Mohammad Alimohammadi Clinical Laboratory of Imam Khomeini Hospital, Khomein, Iran.
  • Mahdi Mosayebi Department of Parasitology, School of Medicine, Arak University of Medical Sciences, Arak, Iran.
  • Mojtaba Didehdar Department of Parasitology, School of Medicine, Arak University of Medical Sciences, Arak, Iran.
Keywords: Human, Male, Testosterone, Toxoplasma gondii

Abstract

 Background: Toxoplasma gondii is an intracellular protozoan parasite that infects human and animals. Toxoplasma parasites are isolated from different parts of ani-mals even from semen but there are little information about the effect of toxo-plasmosis on fertility in animals and humans. In present study, the effect of chronic toxoplasmosis on serum levels of testosterone in men was studied. Methods: In this case-control study, 1026 men referred to Arak Post Marriage Center were selected. Three ml of blood samples were collected and sera separated by centrifugation at room temperature. These sera were analyzed for detection of anti-T. gondii IgG antibody. Next 365 positive sera were selected as cases and also the same number of negative sera (365) as controls. Finally the level of testosterone was analyzed for the cases and controls samples. Result: Serological tests on the sera of 1,026 men in Arak City showed that 365 of them had anti-Toxoplasma antibody. Comparison of testosterone concentration in case and control groups showed that testosterone concentration in case group was less than control group and this difference was statistically significant (P<0.05). Conclusion: The chronic toxoplasmosis could affect reproductive parameters in men.

References

Terpsidis KI, Papazahariadou MG, Taitzoglou IA etl.. Toxoplasma gondii: Reproductive parameters in experimentally infected male rats. Exp Parasitol. 2009; 121(3):238-41.

Stahl W, Dias JA, Turek G. Hypothalamic-adenohypophyseal origin of reproductive failure in mice following chronic infection with Toxoplasma gondii. Exp Biol Med. 1985;(178):246-9.

Stahl W, Kaneda Y, Noguchi T. Reproductive failure in mice chronically infected with Toxoplasma gondii. Parasitol Res. 1994;80(1):22-8.

Antonios S, Ismail H, Essa T. Hypothalamic origin of reproductive failure in chronic experimental toxoplasmosis. J Egypt Soc Parasitol. 2000; 30 (2):593-9.

Oktenli C, Doganci L, Ozgurtas et al. Transient hy-pogonadotrophic hypogonadism in males with acute toxoplasmosis: suppressive effect of inter-leukin1β on the secretion of GnRH. Hum Reprod. 2004; 19(4):859-66.

Arantes TP, Lopes WDZ, Ferreira RM, et al. Toxo-plasma gondii Evidence for the transmission by se-men in dogs. Exp Parasitol. 2009;123(2):190-4.

Lopes WDZ, Da Costa AJ, Santana LF, et al. As-pects of Toxoplasma infection on the reproductive system of experimentally infected rams (Ovis aries). J Parasitol Res. 2009.

Kaňková Š, Kodym P, Flegr J. Direct evidence of Toxoplasma-induced changes in serum testosterone in mice. Exp Parasitol. 2011;128(3):181-3.

Flegr J, Hruskova M, Hodny Z, Novotna M, Hanusova J. Body height, body mass index, waist-hip ratio, fluctuating asymmetry and second to fourth digit ratio in subjects with latent toxoplas-mosis. Parasitology. 2005;130(6):621-8.

Flegr J, Lindová J, Kodym P. Sex-dependent tox-oplasmosis-associated differences in testosterone concentration in humans. Parasitology. 2008; 135(4):427-31.

Hodková H, Kolbeková P, Skallová A, Lindová J, Flegr J. Higher perceived dominance in Toxoplasma infected men-A new evidence for role of increased level of testosterone in toxoplasmosis-associated changes in human behavior. Neuroendocrinol Lett. 2007;28(2):110-4.

Kankova S, Kodym P, Frynta D, Vavrinova R, Kubena A, Flegr J. Influence of latent toxoplas-mosis on the secondary sex ratio in mice. Parasit-ology.2007;134(12):1709-17.

Kaňková Š, Šulc J, Nouzová K, Fajfrlík K, Frynta D, Flegr J. Women infected with parasite Toxoplas-ma have more sons. Naturwissenschaften. 2007;94(2):122-7.

Flegr J, Lindová J, Pivoñková V, Havlíček J. Brief Communication: Latent toxoplasmosis and sali-vary testosterone concentration-Important con-founding factors in second to fourth digit ratio studies. Am J Phys Anthropol. 2008;137(4):479-84.

How to Cite
1.
Eslamirad Z, Hajihossein R, Ghorbanzadeh B, Alimohammadi M, Mosayebi M, Didehdar M. Effects of Toxoplasma gondii Infection in Level of Serum Testosterone in Males with Chronic Toxoplasmosis. IJPA. 8(4):622-6.
Section
Articles