An Insight into the Behavior, Course and Kinetics of Acute Infection of Toxoplasma gondii Human RH Strain in Experimentally Infected Murine Model.
AbstractBackground: Toxoplasma gondii, an apicomplexan parasite, is capable of infecting a broad range of intermediate warm-blooded hosts including humans. The parasite seems to be capable of altering the natural behavior of the host to favor its trans-mission in the environment. The aim of this study was to evaluate the course, alter-ations in behavior along with normal kinetics of the abnormally induced experi-mental acute toxoplasmosis in murine models. Methods: Ten Swiss albino mice were intraperitoneally inoculated with 100 viru-lent RH strain tachyzoites and finally, the alterations in behavior were described and compared with other known alterations in humans and animals. Results: The behavior and the other symptoms of the acute toxoplasmosis were recorded. Such mice showed typical symptoms like normal coat, severe ascites with pendulous abdomen and tachypnoea exhibited by resting fore legs either on walls of the cage, or nozzle of water bottle or other resting mice and yielded a creamy colored cloudy natured peritoneal fluid on aspiration. Conclusions: Finally the alterations in behavior were described and compared with other known alterations in humans and animals. The study has generated some im-portant data related to possible causes of behavioral alterations and generation of suitable strategies for control of these alterations in behavior vis-à-vis better under-standing of the effect of acute infection of parasite on normal behavior of infected intermediate host.
Rorman E, Zamir CS, Rilkis I, Ben-David H. Congenital toxoplasmosis—prenatal aspects of Toxoplasma gondii infection. Re-prod Toxicol. 2006, 21: 458–472.
Zhou P, Chen Z, Li H, Zheng H, He S, Lin R, Zhu X. Toxoplasma gondii infection in humans in China. Parasit Vectors. 2011, 4:165.
Grigg ME, Ganatra J, Boothroyd JC, Margolis TP. Unusual abundance of atyp-ical strains associated with human ocular toxoplasmosis. J Infec Dis. 2000, 184: 633-639.
Balasundaram MB, Andavar R, Pal-aniswamy M, Venkatapathy N. Outbreak of acquired ocular toxoplasmosis involv-ing 248 patients. Archives Ophthalmol. 2010, 128(1): 28-32.
Alapatt JP, Kutty RK, Jose B, Gopi P. A case of cerebral toxoplasmosis in a preg-nant non-immunocompromised pa-tient. Neurol Neurochir Pol. 2009, 43(4): 391–395.
Angel SO, Matrajt M, Margarit J, Nigro M, Illescas E, Pszenny V, Amendoeiva MRR, Guavnera E, Garberi JC. Screening of ac-tive Toxoplasma in patients by DNA hy-bridization with ABGTg7 probe in blood samples. J Clin Microbiol. 1997, 35: 591-595.
Fatzer R. Diffuse Toxoplasmose-Encephalitis in der rechten Grosshirn-halfteeiner Ziege. Schweiz Arch Tierheilkd. 1974, 116: 219.
Dubey JP. Prevention of abortion and neonatal death due to toxoplasmosis by vaccination of goats with the nonpatho-genic coccidium Hammonida hammondi. Am J Vet Res. 1981, 42: 2155.
Hartley WJ, Seaman JT. Suspected Toxo-plasma infection in an adult goat. Vet Pathol. 1981, 19: 210.
Sabin AB. Toxoplasmic encephalitis in children. J Am Med Assoc. 1941, 116:801–807.
Frenkel JK, Dubey JP, Hoff RL. Loss of stages after continuous passage of Toxo-plasma gondii and Besnoitia jellisoni. J Proto-zool. 1976, 23: 421-424.
Dubey JP. The History of Toxoplasma gondii—The First 100 Years. J Eukaryotic Microbiol. 2008, 55(6), 467–475.
Dubey JP. Duration of immunity to shedding to Toxoplasma gondii oocysts by cats. J Parasitol. 1995, 81: 410- 415.
Innes EA. A brief history and overview of Toxoplasma gondii. Zoon Pub Hlth. 2010, 57:1–7.
da Silva RC, Langoni H. Toxoplasma gondii: host–parasite interaction and behavior manipulation. Parasitol Res. 2009, 105: 893–898.
Holliman RE. Toxoplasmosis, behavior and personality. J Inf. 1997, 35:105–110.
Webster JP Rats, cats, people and para-sites: the impact of latent toxoplasmosis on behavior. Microbes Inf. 2001, 3:1037–1045.
Vyas A, Kim SK, Giacomini N, Booth-royd JC, Sapolsky RM. Behavioral chang-es induced by Toxoplasma infection of ro-dents are highly specific to aversion of cat odors. Proc Nat Acad Sci. 2007, 104:6442–6447.
Berdoy M, Webster JP, Macdonald DW Fatal attraction in rats infected with Toxo-plasma gondii. Proc Biol Sci. 2000, 267:1591–1594.
Lamberton PH, Donnelly CA, Webster JP. Specificity of the Toxoplasma gondii-altered behavior to definitive versus non definitive host predation risk. Parasitol. 2008, 135:1143–1150.
Sabin AB. Toxoplasmosis. A recently recognized disease of human beings. Adv Pediatr. 1942, 1:1–53.
Gatkowska J, Wieczorek M, Dziadek B, Dzitko K, Dlugonska H. Behavioral changes in mice caused by Toxoplasma gondii invasion of brain. Parasitol Res. 2011, DOI 10.1007/s00436-011-2800-y
Carruthers VB, Suzuki Y. Effects of Toxo-plasma gondii infection on the brain. Schiz-ophrenia Bull. 2007, 33:745–751.
Ferguson DJ, Hutchison WM. An ultra-structural study of the early development and tissue cyst formation of Toxoplasma gondii in the brains of mice. Parasitol Res. 1987, 73:483–491.
Holliman RE. Toxoplasmosis, behavior and personality. J Infect. 1997, 35:105–110.
Gulinello M, Acquarone M, Kim JH, Spray DC, Barbosa HS, Sellers R, Tan-owitz HB, Weiss LM. Acquired infection with Toxoplasma gondii in adult mice results in sensorimotor deficits but normal cogni-tive behavior despite widespread brain pa-thology. Microbes Inf. 2010, 12:528–537.
Hay J, Aitken PP, Graham DI. Toxo-plasma infection and response to novelty in mice. Parasitol Res. 1984, 70:575–588.
Prandovszky E, Gaskell E, Martin H, Dubey JP, Webster JP, McConkey GA. The neurotropic parasite Toxoplasma gondii increases dopamine metabolism. PLoS One. 2011, 6:e23866.
Stibbs HH. Changes in brain concentra-tions of catecholamines and indoleamines in Toxoplasma gondii infected mice. Ann Trop Med Parasitol. 1985, 79:153–157.
Flegr J. Effects of toxoplasma on human behavior. Schizophrenia Bull. 2007, 33: 757–760.
Yolken RH, Dickerson FB, Fuller Torrey E. Toxoplasma and schizophrenia. Parasit Imm. 2009, 31:706–715.
Miman O, Kusbeci OY, Aktepe OC, Cetinkaya Z. The probable relation be-tween Toxoplasma gondii and Parkinson’s disease. Neurosci Let. 2010, 475:129–131.
Stommel EW, Seguin R, Thadani VM, Schwartzman JD, Gilbert K, Ryan KA, Tosteson TD, Kasper LH. Cryptogenic epilepsy: an infectious etiology? Epi-lep.2001, 42:436–438.
Zhu S. Psychosis may be associated with toxoplasmosis. Med Hyp. 2009, 73:799–801.