The Rate of Plasmodium vivax Infectivity within Gloucose-6-Phosphate Dehydrogenase (G6PD) Deficient Individuals in Hormozgan Province, Iran.

  • Mohammad Ebrahimipour Department of Parasitology, School of Public Health, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
  • Mehdi Nateghpour Department of Parasitology, School of Public Health, Tehran University of Medical Sciences (TUMS), Tehran, Iran ; National Institute of Health Research, TUMS, Tehran, Iran.
  • Homa Hajjaran Department of Parasitology, School of Public Health, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
  • Gholamhosein Edrissian Department of Parasitology, School of Public Health, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
  • Mahmood Jalali Department of Biochemistry, School of Medicine, TUMS, Tehran, Iran.
  • Ahmad Raeisi Center for Disease Control and Management, Ministry of Health& Medical Education, Tehran, Iran.
  • Afsaneh Motevalli Haghi Department of Parasitology, School of Public Health, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
  • Leila Farivar Department of Parasitology, School of Public Health, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
  • Masomeh Khodadadi Department of Parasitology, School of Public Health, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
  • Abas Rahimi-Froushani Department of Epidemiology and Biostatistics, School of Public Health, TUMS, Tehran, Iran.
Keywords: G6PD deficiency, Iran, Malaria, Plasmodium vivax

Abstract

Background: One of the most important enzymatic disorders that interact with malaria is deficiency of G6PD (Gloucose-6-phosphate dehydrogenase). This enzyme protects red blood cells from hydrogen peroxide and other oxidative damages. Distribution of this enzyme deficiency usually accompanies with low level distribution of malaria disease in most malarious areas. So this hypothesis may be considered that the G6PD deficiency could be protective against malaria.Methods: Totally 160 samples were taken from vivax malaria infected and non-infected individuals. Preparing blood smears and quantitative test for G6PD deficiency were employed for all of the samples. To ensure accuracy of the malaria in negative samples besides using microscopical examination,semi-nested multiplex PCR was also performed for the two groups.Results: In microscopical examination 36 and 124 samples were vivax malaria positive and negative respectively. Out of 36 P.vivax positive cases 3 (8.3%) cases were detected to be G6PD deficient versus 30 (24.2%) cases out of 124 P. vivax negative cases. The results showed a significant differentiation between P. vivax positive and P. vivax negative cases in the rate of G6PD deficiency (3/36 in positive cases versus 30/124 in negative cases) (P<0.05).Conclusion: vivax malaria positive individuals with G6PD deficiency showed too mild symptoms of Malaria or even asymptomatic.

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How to Cite
1.
Ebrahimipour M, Nateghpour M, Hajjaran H, Edrissian G, Jalali M, Raeisi A, Motevalli Haghi A, Farivar L, Khodadadi M, Rahimi-Froushani A. The Rate of Plasmodium vivax Infectivity within Gloucose-6-Phosphate Dehydrogenase (G6PD) Deficient Individuals in Hormozgan Province, Iran. IJPA. 9(3):402-6.
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