Iranian Journal of Parasitology 2014. 9(3):402-406.

The Rate of Plasmodium vivax Infectivity within Gloucose-6-Phosphate Dehydrogenase (G6PD) Deficient Individuals in Hormozgan Province, Iran.
Mohammad Ebrahimipour, Mehdi Nateghpour, Homa Hajjaran, Gholamhosein Edrissian, Mahmood Jalali, Ahmad Raeisi, Afsaneh Motevalli Haghi, Leila Farivar, Masomeh Khodadadi, Abas Rahimi-Froushani


Background: One of the most important enzymatic disorders that interact with malaria is deficiency of G6PD (Gloucose-6-phosphate dehydrogenase). This enzyme protects red blood cells from hydrogen peroxide and other oxidative damages. Distribution of this enzyme deficiency usually accompanies with low level distribution of malaria disease in most malarious areas. So this hypothesis may be considered that the G6PD deficiency could be protective against malaria.

Methods: Totally 160 samples were taken from vivax malaria infected and non-infected individuals. Preparing blood smears and quantitative test for G6PD deficiency were employed for all of the samples. To ensure accuracy of the malaria in negative samples besides using microscopical examination,semi-nested multiplex PCR was also performed for the two groups.

Results: In microscopical examination 36 and 124 samples were vivax malaria positive and negative respectively. Out of 36 P.vivax positive cases 3 (8.3%) cases were detected to be G6PD deficient versus 30 (24.2%) cases out of 124 P. vivax negative cases. The results showed a significant differentiation between P. vivax positive and P. vivax negative cases in the rate of G6PD deficiency (3/36 in positive cases versus 30/124 in negative cases) (P<0.05).

Conclusion: vivax malaria positive individuals with G6PD deficiency showed too mild symptoms of Malaria or even asymptomatic.


G6PD deficiency; Iran; Malaria; Plasmodium vivax

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Edrissian GhH, Nateghpour M, Afshar A, Sayedzadeh A, Mohsseni Gh, Satvat MT, Emadi AM. Monitoring the response of Plasmodium falciparum and P. vivax to antimalarial drugs in the malarious areas in sout-east Iran. Arc Iranian Med. 1999; 2(2): 61-6.

Collins WE. Plasmodium knowlesi: A malaria parasite of monkeys and humans. Ann Rev Entomol. 2012; 57: 107-121.

World Health Organization. World malaria report. 2009; Available from:

Leslie T, Bricen M, Mayan I, Mohammed N, Klinkenberg E, Hopkins Sibley C, Whitty CJM, Rowland M. The impact of phenotypic and genotypic G6PD deficiency on risk of Plasmodium vivax infection: A case-control study amongst Afghan refugees in Pakistan. Plos Med. 2010; 7(5).

Cappellini MD, Fiorelli G. Glucose-6-phosphate dehydrogenase deficiency. Lancet. 2008; 371: 64-74.

Mohammad Ganji SH, Noori Daloii MR. G6PD study in Iran; Incidence. Mol Genet Analysis. 2007.

Farhud DD, Yazdanpanah L. Glucose-6-phosphate dehydrogenase (G6PD) deficiency. Iran J Public Health. 2008; 37(4).

Noori Daloii MR, Hajebrahimi Z, Najafi L, Mesbah-Namin SA, Mowjoodi A, Mohammad Ganji S, Yekaninejad MS, Sanati MS. A comprehensive study on the major mutations in glucose- 6-phosphate dehydrogenase deficient polymorphic variants identified in the coastal provinces of Caspian Sea in the north of Iran. Clin Biochem. 2007; 40(9-10): 699-704.

Kazeminezhad SR, Mashayekhi A, Khatami SR, Daneshmand S, Fahmi F, Ghaderigandmani M, Jalali-Far MA. Prevalence and molecular identification of Mediterranean glucose-6-phosphate dehydrogenase deficiency in Khuzestan province, Iran. Iran J Public Health. 2009; 38(3): 127-131.

John GK, Douglas NM, Seidlein L, Nosten F, Baird JK, White NJ, Price RN. Primaquine radical cure of Plasmodium vivax. Malaria J. 2012; 11: 280.

Technical manual, Model 7940 ACD-A, Anticoagulant Citrate Dextrose Solution A, US, 2001 Boehringer Laboratories, Inc.

Henning L, Felger I, Beck HP. Rapid DNA extraction for molecular epidemiological studies of malaria. Acta Trop. 1999; 72(2): 149-55.

Kaneko A, Taleo G, Kalkoa M, Yaviong J, Reeve PA, Ganczakowski M, Shirakawa C, Palmer K, Kobayakawa T, Bjorkman A. Malaria epidemiology, glucose-6-phosphate dehydrogenase deficiency and human settlement in the Vanuata Archipelago. Acta Trop. 1998; 70(3): 285-302.

Nateghpour M, Miahipour A, Yousefi M, Mohammadiha A, Fagani Y. A patient with G6PD deficiency and falciparum malaria. Iran J Parasitol. n2007; 2(1): 43-45.

Edrissian GhH, Montazemi K, Nasseri AR, Afshar A. Malaria antibodies and glucose-6-phosphate dehydrogenase (G-6-PD) deficiency. Iran J Public Health. 1983; 12(1-4): 9.

Rebholz CE, Michel AJ. Frequency of malaria nand glucose-6-phosphate dehydrogenase deficiency in Tajikistan. Malaria J. 2006; 5: 51.

Matsuoka H, Arai M, Yoshida S, Tantular IS, Pusarawati S, Kerong H, Kawamoto F. Five different glucose-6-phosphate dehydrogenase (G6PD) variant found among 11 G6PD deficient persons in Flores Island, Indonesia. J Hum Genet. 2003; 48: 541-544.

Shimizu H, Tamam M. Glucose-6-phosphate dehydrogenase deficiency and Southeast Asian ovalocytosis in asymptomatic Plasmodium carriers in Sumba Island, Indonesia. J Hum Genet. 2005; 50: 420-424.


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