Iranian Journal of Parasitology 2014. 9(4):553-559.

Herbal Remedies Connected to Malaria like Fever in Iranian Ancient Medicinal Books- Brief Review Article.
Azadeh Ghiaee, Farzaneh Naghibi, Somayeh Esmaeili, Mahmoud Mosaddegh


Malaria is a major international public health problem. Drug-resistant parasites have made treatment and control of malaria more difficult. Therefore, safe, affordable and effective new drugs are urgently needed. Traditional medicine is an important source for new drugs. Determining the ancient medicinal books was the first step of this study for finding malaria or disease that has symptoms like malaria. Then the plants that used to treat “Ghebbe Khalesseh fever” were listed. Finally, recent antimalarial researches were explored. About 31 plants were identified. Information from these resources is valuable for the selection of plants for antiplasmodial screening programs.


Malaria; Medicinal plant; Plasmodium; Traditional medicine

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WHO fact sheet malaria; 2010. Available from: s094/en/.

Brooks GF, Carroll KC, Butel JS, Morse SA. Parasitology. In: Jawetz, Melnick, & Adelberg's Medical Microbiology 24th ed. New York: McGraw-Hill; 2007. Chapter 46.

Adams M, Alther W, Kessler M, Kluge M, Hamburger M. Malaria in the renaissance:Remedies from European herbals from the 16th and 17th century. J Ethnopharmacol. 2011; 133:278-88.

WHO-TDR the World Health Organization, Special Programme for Research and Training in Tropical Diseases. April 26th 2006 revision date. Malaria. Available from:

Willcox M, Bodeker G, Rasoanaivo P. Traditional medicinal plants and malaria. CRC Press: Boca Raton; 2004.

Saxena S, Neerja Pant N, Jain DC, Bhakuni RS. Antimalarial agents from plant sources. Current Science. 2003; 85(9):1314-29.

White NJ. Qinghaosu (Artemisinin): the price of success. Science. 2008; 320:330-4.

Willcox M.L, Bodeker G. Traditional herbal medicines for malaria. Br Med J. 2004; 329:1156-9.

Bourdy G, Willcox M.L, Ginsburg H, Rasoanaivo Ph, Graz B, Deharo E. Ethnopharmacology and malaria: New hypothetical leads or old efficient antimalarials? Int J Parasitol. 2008; 38:33-41.

Edrissian GhH. Malaria in Iran: Past and Present situation. Iran J Parasitol. 2006; 1(1):1-14.

Packard RM. The making of a Tropical Disease. The John Hopkins University Press. Baltimore: Maryland; 2007.

Avicenna. Canon in Medicine (in Arabic). 1st ed. Dar Ihya al-Turath al-Arabi: Beirut; 2005. vol.4.

Muhammad ibn Zakariya Razi. Al-Mansouri(in Arabic). 1st ed. Arab League Education, Culture and Science Organization: Kuwait; 1987.

Ahmad Akhawayni Bukhari. Hedayat al- Motaallemin fi-Tebb (in Persian). 2nd ed. Mashhad University. Mashhad: Iran; 1992.

Ismaeil Jurjani. Zakhireyi Kharazmshahi (in Persian). 1st ed. Tehran: Academy of Medical Sciences. Tehran: Iran; 2001.

Bahaaddin Nurbakhsh. Khulasat al-Tajarub (in Persian). 1st ed. Tehran University of Medical Sciences. Tehran: Iran; 2008.

Hakim Mohammad Akbar Arzani. Tebbe Akbari (in Persian). 1st ed. Institute of Natural Medicine. Qom: Iran; 2008.

Seyyid Mohammad Hossein. Makhzan al- Adwiyyah (in Persian). 1st ed. Tehran University of Medical Sciences. Tehran: Iran; 2011.

Amin Gh. Popular medicine plants of Iran. Medical Science Tehran University and Ethic and Medical History Research Centre. Tehran: Iran; 2005.

Ghahreman A, Okhovvat AR. Matching the old medicinal plant names with scientific terminology. University of Tehran Press. Tehran: Iran; 2004.

Soltani A. Encyclopedia of Traditional Medicine (Dictionary of Medicinal Plants). Iran University of Medical Sciences and Health Services. Tehran: Iran; Vol(s). 1-3.

Pinmai K, Hiriote W, Soonthornchareonnon N, Jongsakul K, Sireeratawong S, Tor-Udom S. In vitro and In vivo Antiplasmodial Activity and Cytotoxicity of Water Extracts of Phyllanthus emblica, Terminalia chebula, and Terminalia bellerica. J Med Assoc Thai. 2010; 93(7):120-6.

Bischoff TA, Kelley CJ, Karchesy Y, Laurantos M, Nguyen-Dinh P, Arefi AG. Antimalarial activity of lactucin and lactucopicrin: sesquiterpene lactones isolated from Cichorium intybus L. J Ethnopharmacol. 2004; 95(2-3):455-7.

Asase A. Ethnobotanical study of some Ghanaian anti-malarial plants. J Ethnopharmacol. 2005; 99:273-9.

Koudouvo K, Karou SD, IIboudo DP, Kokou K, Essien K, Aklikokou K, de Souza C, Simpore J, Gbeassor M. In vitro antiplasmodial activity of crude extracts from Togolese medicinal plants. Asian Pac J Trop Med. 2011; 4(2); 129-32.

Dell’Agli M, V.Galli G, Corbett Y, Taramelli D, Lucantoni L, Habluetzel A, Maschi O, Caruso D, Giavarini F, Romeo S, Bhattacharya D, Bosisio E. Antiplasmodial activity of Punica granatum L. fruit rind. J Ethnopharmacol. 2009; 125(2):279-85.

Esmaeili S, Naghibi F, Mosaddegh M, Sahranavard S, Ghafari S, Abdullah NR. Screening of antiplasmodial properties traditionally used among some Iranian plants. J Ethnopharmacol. 2009; 121(3):400-4.

Sianne S and Fanie RVH. Antimalarial activity of plant metabolites. Nat Prod Rep. 2002; 19:675-92.

Rastogi RP and Mehrotra BN. Compendium of Indian Medicinal Plants published by Central Drug Research Institute, Lucknow and National

Institute of Sciences Communication and Information Resources. New Delhi: India; 1990-1994; 6: 395-8.

Ruiz La, Ruiz Li, Maco M, Cobos M, Gutierrez-Choquevilca A, Roumy V. Plants used by native Amazonian groups from the Nanay River (Peru) for the treatment of malaria. J Ethnopharmacol. 2011; 133(2):917-21.


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