New Nodule Type Found in the Lungs of Pomacea canaliculata, an Intermediate Host of Angiostrongylus cantonensis

  • Yue GUO 1. School of Medicine, Huzhou University, Huzhou, China
  • Hong Chang ZHOU 1. School of Medicine, Huzhou University, Huzhou, China
  • Ying DONG 1. School of Medicine, Huzhou University, Huzhou, China
  • Ting ZHANG 1. School of Medicine, Huzhou University, Huzhou, China
  • Yu Yang SUN 1. School of Medicine, Huzhou University, Huzhou, China
  • Jian Feng ZHONG 2. Infectious Diseases Dept., Huzhou Central Hospital, Huzhou, China
  • Yu Liang CAO 3. Intensive Medicine, No.98 Hospital of PLA, Huzhou, Zhejiang, China
  • Sheng Wen SHAO 1. School of Medicine, Huzhou University, Huzhou, China
  • Yong Liang PAN 1. School of Medicine, Huzhou University, Huzhou, China
  • Hai Yan DONG 1. School of Medicine, Huzhou University, Huzhou, China
Keywords: Pomacea canaliculata, Lung nodule, 18S ribosomal RNA, Poterioochromonas sp, Angiostrongylus cantonensis


Background: Pomacea canaliculata (P.canaliculata) lung nodules, were commonly caused by Angiostrongylus cantonensis infection. Here, we found a new nodule type without any parasites. Methods: Overall, 447 P. canaliculata snails were collected in Ning Bo, Zhe Jiang, China in 2018. In order to exhibit the similarities and differences between two nodules types (2018, Huzhou Zhejiang, China), both types were collected in formalin for tissue pathological sectioning. Besides, to obtain the microbial community of the new nodule, the 18S ribosomal RNA (rRNA) gene of it was amplified and analyzed using the Illumina second-generation sequencing platform. Results: Although two nodules were found in the lungs of P. canaliculata, they were different in shape and pathology. Illumina sequencing indicated Poterioochromonas sp., a species of golden algae, might be the causing agent of the new nodule. Conclusion: We firstly found a new pathological nodule type in the lungs of P. canaliculata, and this nodule might be induced by golden algae infection, however, the direct link between the golden algae and the new nodules, as well as the nodules’ impact on the snails’ physiology and A. cantonensis infection require further study.

Author Biography

Yue GUO, 1. School of Medicine, Huzhou University, Huzhou, China
School of Medicine, Hu Zhou University, No. 759, East 2nd Road, Huzhou, Zhe Jiang, China


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How to Cite
GUO Y, ZHOU HC, DONG Y, ZHANG T, SUN YY, ZHONG JF, CAO YL, SHAO SW, PAN YL, DONG HY. New Nodule Type Found in the Lungs of Pomacea canaliculata, an Intermediate Host of Angiostrongylus cantonensis. IJPA. 13(3):362-8.
Original Article(s)