Tehran University of Medical Sciences Iranian Journal of Parasitology 1735-7020 18 3 2023 09 22 400 403 Taliha Karakök Infectious Disease Deparment, Fatsa State Hospital, Ordu, Türkiye 2022 11 16 2023 09 22 Splenic infarction is a rare complication of both malaria and COVID-19. We report a splenic infarction case due to COVID-19 and malaria co-infection. A 35‑year‑old male with no known chronical disease tested positive for both COVID-19 and malaria in Turkey in 2022. Oral artemether and lumefantrine treatment was started. On the third day of the treatment, he complained about a severe left upper quadrant pain. A repeated abdominal CT showed splenomegaly and 8 cm diameter hypodense areas throughout the spleen consistent with splenic infarction. The patient was discharged with low molecular weight heparin. A rare complication that can be seen in both diseases developed a more rigorous recommendation for anticoagulant therapy is needed for co-infections of COVID-19 with diseases that may present similar thrombotic complications. https://ijpa.tums.ac.ir/index.php/ijpa/article/view/3797 https://ijpa.tums.ac.ir/index.php/ijpa/article/download/3797/1313