Tehran University of Medical Sciences Iranian Journal of Parasitology 1735-7020 18 2 2023 06 27 257 261 Aida Vafae Eslahi Medical Microbiology Research Center, Qazvin University of Medical Sciences, Qazvin, Iran Negar Sheikhdavoodi Metabolic Diseases Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin Unversity of Medical Sciences, Qazvin, Iran Milad Badri Medical Microbiology Research Center, Qazvin University of Medical Sciences, Qazvin, Iran 2. Metabolic Diseases Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran 2022 09 24 2022 12 26 Crusted scabies (CS) is an extremely contagious variant of classical scabies with substantial morbidity and mortality. It is the most prevalent in immunocompromised patients, those with some underlying diseases, and individuals with physical and mental disabilities. Herein, we report a 70-year-old woman who presented with generalized erythema with itchy hyperkeratotic plaques and crusted lesions on her face, hands, between fingers, neck, scalp, abdomen, and legs up to the knees. She was diagnosed with CS and subsequently isolated and treated with ivermectin (200 μg/kg) and 5% permethrin cream. She died a short time after being admitted, and it was due to severe septic shock and cardiac arrest. Immediate isolation and treatment of CS patients is essential to prevent morbidity and mortality. Prompt diagnosis and precise medical management in both patients and healthcare settings is required. https://ijpa.tums.ac.ir/index.php/ijpa/article/view/3742 https://ijpa.tums.ac.ir/index.php/ijpa/article/download/3742/1295