Tehran University of Medical Sciences Iranian Journal of Parasitology 1735-7020 18 2 2023 06 27 251 256 Donya Maleki Department of Infectious Diseases, School of Medicine, Iran University of Medical Sciences, Tehran Iran Sam Zeraatian-Nejad Davani Department of Cardiovascular Surgery, Rasool akram Hospital, Iran University of Medical Sciences, Tehran, Iran Mahshid Talebi-Taher 1. Department of Infectious Diseases, School of Medicine, Iran University of Medical Sciences, Tehran Iran 2. Antimicrobial Resistance Research Center, Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran Iran Borna Salemi Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Irana Khadijeh Khanaliha Research Center of Pediatric Infectious Diseases, Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran 2022 06 29 2022 10 23 Hydatid cyst mainly involves the liver and lung; however, it can rarely involve cardiac tissue. This study describes the presence of hydatid cysts in the heart with considerable disease points in Tehran, Iran. Two cases aged between 25 to 50 years with cardiac hydatid cyst involvement were identified in 2021 in Tehran, Iran. Epicardial hydatid cyst between a left anterior descending coronary artery (LAD) and left obtuse marginal artery (OM) on the left ventricle, and in the second case, intrapericardial cyst attached to the pulmonary trunk with a thin base were identified. The cardial cysts were resected, and the patients recovered without any complications.  Cardiac hydatid cyst is a very rare disease. Rapid diagnosis and surgical and medical care are necessary for treatment. https://ijpa.tums.ac.ir/index.php/ijpa/article/view/3662 https://ijpa.tums.ac.ir/index.php/ijpa/article/download/3662/1294