Tehran University of Medical Sciences Iranian Journal of Parasitology 1735-7020 17 2 2022 05 28 138 144 Zahra Mirabedini Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Naveed Ahmed Khan Department of Clinical Sciences, University of Sharjah College of Medicine, University City, Sharjah, 27272, United Arab Emirates Maryam Niyyati Department of Parasitology and Mycology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Ehsan Javanmard Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Mohammad Hamedanipour Department of Clinical Science, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran Zahra Arab-Mazar Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran 2021 10 27 2022 04 10 Acanthamoeba is a free-living amoeba that has been found on surfaces, air, water and various environmental sources around the world. It enters the human body through the respiratory tract via the nose. Of note, amoebae are well known to act as a reservoir for various pathogenic microorganisms including bacteria and viruses such as Adenoviruses and Mimivirus. Given that SARS-CoV-2 of the Coronaviridae family is transmitted through the respiratory tract, and the Trojan horse nature of Acanthamoeba, it has been suggested that amoebae act as a vector in the transmission of SARS-CoV-2. The aim of this study was to provide an opinion of the possibility of the coexistence of Acanthamoeba with SARS-CoV-2. https://ijpa.tums.ac.ir/index.php/ijpa/article/view/3491 https://ijpa.tums.ac.ir/index.php/ijpa/article/download/3491/1206