Tehran University of Medical Sciences Iranian Journal of Parasitology 1735-7020 16 4 2021 11 24 538 547 Le Phuc 1. Medic Medical Center, Ho Chi Minh City, Vietnam 2. National Institute of Malaria, Parasitology and Entomology of Vietnam, Ha Noi, Vietnam Cao Loi Scientific and Training Management Department, National Institute of Malaria, Parasitology and Entomology of Vi-etnam, Ha Noi, Vietnam Huynh Quang Institute of Malariology, Parasitology and Entomology Quy Nhon, Binh Dinh, Vietnam Le Vinh Medical Parasitology Unit, Department of Fundamental Sciences and Basic Medical Sciences, The University of Medi-cine Pham Ngoc Thach, Infectious E Department, Hospital for Tropical Disease, Ho Chi Minh City, Vietnam Cao Sinh Vinh Medical University, Vinh, Nghe An, Vietnam Vu Du National Hospital of Obstetrics and Gynecology, Ha Noi, Vietnam Que Tram Department of Tropical Diseases, Vinh Hospital of Friendship General, Vinh, Nghe An, Vietnam Khong Quang National Hospital for Tropical Disease, Ha Noi, Vietnam Tang Hai Department of Otorhinolaryngology, Nghe An Obstetrics and Pediatrics Hospital, Vinh, Nghe An, Vietnam Tran-Anh Le Department of Parasitology, Vietnam Military Medical University, Ha Noi, Vietnam 2021 01 16 2021 06 15 Background: Human toxocariasis is prevalent in many countries but this disease has been rarely reported from Vietnam. We aimed to investigate the clinical and laboratory findings and assess possible association between these findings in patients with toxocariasis in Vietnam. Methods: A prospectively study, between October 2017 and June 2019 was performed involving 120 toxocariasis patients at Medic Medical Center, Ho Chi Minh City, Vietnam. The diagnosis of toxocariasis was established based on clinical, laboratory (eosinophilia, raised IgE concentration) and serological (positive Toxocara IgG ELISA test) evaluation as well as the exclusion of other helminthic coinfection.   Results: The most frequently reported manifestation was of skin (n = 93, 77.5%), including urticarial (n= 69, 57.5%) followed by neurologic, gastrointestinal and pulmonary signs/symptoms. Hepatic involvement occurred in 8.3% of the patients. No significant relationship between clinical findings and laboratory parameters was found except the higher values of eosinophil count and IgE concentration among patients with liver involvement. There was a significant relationship between eosinophil count and IgE concentration (r=0.389, P<0.001). Serological findings did not show a correlation with clinical and other laboratory findings. Conclusion: Our data revealed a wide range of clinical symptoms/signs and a high incidence of skin manifestations in patients with toxocariasis. Eosinophil count and IgE concentration are valuable markers for the evaluation of the disease. https://ijpa.tums.ac.ir/index.php/ijpa/article/view/3240 https://ijpa.tums.ac.ir/index.php/ijpa/article/download/3240/1167