Tehran University of Medical Sciences Iranian Journal of Parasitology 1735-7020 10 2 2015 06 15 296 300 EN Hossein Mortazavi Dept. of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran. Mehdi Mohebali Dept. of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran AND Center for Research of Endemic Parasites of Iran (CREPI), Tehran University of Medical Sciences, Tehran, Iran. Yasaman Taslimi Molecular Immunology and Vaccine Research Laboratory, Pasteur Institute of Iran, Tehran, Iran. Pardis Sadeghipour Molecular Immunology and Vaccine Research Laboratory, Pasteur Institute of Iran, Tehran, Iran. Mahsa Ansari Dept. of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran. Kambiz Kamyab Department of Pathology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran. Marjan Talebi Dept. of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran. Ali Khamesipour Skin and Leprosy Research Center, Tehran University of Medical Sciences, Tehran, Iran. 2015 10 14   Herein, a 28-year-old man with hoarseness, skin and oral lesions is presented. At the time of admission, the patient had an erythematous plaque on his chin near his lower lip and an erythematous-violaceous plaque on his palate near the open-ing of the pharynx and 20 kg weight lost in last one year. The biopsy of his skin lesions by hematoxylin and eosin staining revealed an infiltration of the dermis by lymphoplasma and histiocytic cells with a loose granuloma formation sugges-tive of leishmaniasis. Biopsy of mucosal lesions revealed Leishman bodies in dermis. PCR was performed on the specimens of skin, bone marrow, mucosa, and saliva, the results were positive. The pathogenic agent was identified as Leishmania major by the nested PCR. Serologic tests including direct agglutination test (DAT) and indirect immunofluorescence test (IFAT) were positive with high titers of anti-L. infantum antibodies (1:102400 versus 1:800, respectively), indicative of visceral involvement. The patient responded to a combination of miltefosine and meglumine antimoniate (Glucantime®). Visceral involvement due to L. major is rarely reported. To the best of our knowledge, probably hoarseness due to L. major has not been previously reported from Iran. https://ijpa.tums.ac.ir/index.php/ijpa/article/view/319 https://ijpa.tums.ac.ir/index.php/ijpa/article/download/319/493