Tehran University of Medical Sciences Iranian Journal of Parasitology 1735-7020 16 4 2021 11 24 697 702 EN Sury Antonio López-Cancino 1. Laboratory of Parasitology Research, Federico Gómez Children´s Hospital of Mexico, Mexico City, Mexico 2. Research Center of Health Sciences, Faculty of Health Sciences, Anahuac México University, Huixquilucan, State of México, México 3. Autonomous University of Chiapas. Tuxtla Gutiérrez, Chiapas, México Jorge Fernando Méndez-Galván Unit of Emerging Infectious Diseases Research, Federico Gómez Children Hospital of Mexico, Mexico City, Mexico Mariana Guerrero Laboratory of Parasitology Research, Federico Gómez Children´s Hospital of Mexico, Mexico City, Mexico Marcos Meneses-Mayo Research Center of Health Sciences, Faculty of Health Sciences, Anahuac México University, Huixquilucan, State of México, México Sergio Agustín Islas-Andrade 1. Research Center of Health Sciences, Faculty of Health Sciences, Anahuac México University, Huixquilucan, State of México, México 2. American British Cowdray Medical Center, Mexico City, Mexico Enedina Cardoso Laboratory of Parasitology Research, Federico Gómez Children´s Hospital of Mexico, Mexico City, Mexico 2020 10 10 2021 05 17 Congenital Chagas disease is considered a form of dispersion of Trypanosoma cruzi related to human migration from endemic, often rural to previously non-endemic urban areas. This fact increases the Chagas disease establishment risk inside of family members by vertical transmission pathway. Congenital Chagas disease cases in newborns could not identified by the health professional even in endemic regions. Here we present the first family cluster of Chagas disease cases from Chiapas: one of the most important endemic areas in South of Mexico, where vertical T. cruzi transmission incidence rate is ranged between 2% to 22% revealing an important public health problem. Two cases inside a family from Chiapas, México with positive antibodies against T. cruzi detected by ELISA are presented; one of them got the infection through vertical pathway. We think that congenital Chagas disease should not be ignored in a newborn born from an asymptomatic Chagas disease mother, who may transmit the parasite infection randomly. https://ijpa.tums.ac.ir/index.php/ijpa/article/view/3117 https://ijpa.tums.ac.ir/index.php/ijpa/article/download/3117/1186