Tehran University of Medical Sciences Iranian Journal of Parasitology 1735-7020 15 3 2020 09 12 457 462 Mahmooud AHMADI-HAMEDANI Department of Clinical Sciences, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran Hediyeh HOSSEINPOUR Veterinary Medicine, Semnan University, Semnan, Iran Hesamodin ESKAFIAN Department of Clinical Sciences, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran Shayan DAVARPANAH Veterinary Medicine, Semnan University, Semnan, Iran 2020 09 12 Cutaneous involvement in canine leishmaniasis, caused by Leishmania infantum, is the most frequent clinical manifestation of the zoonotic infectious disease. A 4-month-old female Shih Tzu-terrier dog with significant weight loss and depression and chronic erosive skin lesions around eyes and the area above the nose was presented to the Semnan University Veterinary Hospital teaching, Semnan, Iran. The main clinicopathological findings included marked leukocytosis, neutrophilia, left shift, monocytosis, mild hypoproteinemia, and hypoalbuminemia. The diagnosis of leishmaniasis was performed based on the presence of a large number of Leishmania amastigotes in skin Fine Needle Aspiration (FNA). The dog was euthanized and sent to the autopsy department for further investigation. https://ijpa.tums.ac.ir/index.php/ijpa/article/view/3077 https://ijpa.tums.ac.ir/index.php/ijpa/article/download/3077/1079