Tehran University of Medical Sciences Iranian Journal of Parasitology 1735-7020 13 4 2018 12 22 637 642 EN Maryam KHALILI Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran AND Dept. of Parasitology and Mycology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Mahmoud MAHAMI-OSKOUEI Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran AND Dept. of Parasitology and Mycology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Abbas SHAHBAZI Dept. of Parasitology and Mycology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Abdolrasoul SAFAIYAN Road Traffic Injury Research Center, Tabriz University of Medical Sciences, Tabriz, Iran AND Dept. of Biostatistics and Epidemiology, Faculty of Health, Tabriz University of Medical Sciences, Tabriz, Iran Nader MOHAMMADZADEH-GHESHLAGHI Central Medical Laboratory of East Azerbaijan Province, Tabriz University of Medical Sciences, Tabriz, Iran Leyla MAHAMI-OSKOUEI Dept. of Parasitology and Mycology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran 2017 02 06 2017 09 20 Background: This study investigated the presence of specific antibodies against Toxoplasma gondii infection among people with diabetes (type I and II) in comparison with control group. Methods: Overall 300 serum samples were collected equally from three groups including patients with type I and type II diabetes and non-diabetic healthy control that referred to Tabriz Central Laboratory in northwest Iran during July to Sep 2015. The level of specific IgG and IgM antibodies against T. gondii were measured using the chemiluminescence immunoassay (CLIA) method. Chi-square and One-Way ANCOVA were used for data analysis. Results: Overall, 300 samples from diabetic patients (type I and type II) and control group were examined and results showed 3, 8 and 2 cases were seropositive for anti- T. gondii IgM respectively. Anti- T. gondii IgG seropositivity in type I and type II diabetes and control groups were 69%, 63% and 59% respectively. We did not observe any statistical differences among all studied groups in terms of toxoplasmosis. There was no statistically significant relationship between all variables and seropositivity for anti-T. gondii antibodies in type I and II diabetes and non-diabetic groups. Conclusion: Although there was no statistically significant relationship between diabetes and toxoplasmosis further investigations especially experimental studies using animal models are needed. Furthermore, these findings would not be contrary to the need for healthcare in order to the prevention of infectious disease in diabetic patients. https://ijpa.tums.ac.ir/index.php/ijpa/article/view/1466 https://ijpa.tums.ac.ir/index.php/ijpa/article/download/1466/890