Tehran University of Medical Sciences Iranian Journal of Parasitology 1735-7020 13 4 2018 12 18 549 559 EN Hossein DEHGHAN Dept. of Medical Entomology & Vector Control, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Mohammad Ali OSHAGHI Dept. of Medical Entomology & Vector Control, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Seyed Hassan MOSA-KAZEMI Dept. of Medical Entomology & Vector Control, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Mohammad Reza ABAI Dept. of Medical Entomology & Vector Control, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Fatemeh RAFIE Dept. of Medical Entomology & Vector Control, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Mehdi NATEGHPOUR Dept. of Parasitology and Medical Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Habib MOHAMMADZADEH Cellular and Molecular Research Center, Urmia University of Medical Sciences, Urmia, Iran AND Dept. of Medical Parasitology and Mycology, School of Health, Urmia University of Medical Sciences, Urmia, Iran Leila FARIVAR Dept. of Parasitology and Medical Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Mulood MOHAMMADI BAVANI Dept. of Medical Entomology, School of Health, Urmia University of Medical Sciences, Urmia, Iran 2016 11 08 2017 07 18 Background:Plasmodium berghei is a rodent malaria parasiteand has been very valuable means in the progress of our understanding of the essential molecular and cellular biology of the malaria parasites. Availability of hosts such as mice and vectors such as Anopheles stephensi has made this parasite a suitable system to study the parasite-host and vector-parasite relationships. Numerous studies have described life cycle and parameters influencing maintenance of the parasite within the mice or the mosquito. In this paper we revealed more details and have addressed some parameters and points influence maintenance of various life stages of the parasite (merozoites, macrogametocytes, ookinetes, oocysts and sporozoites) in the laboratory model P.berghei–A.stephensi-BALB/c mouse. This study helps understanding the biology of vertebrate-parasite and mosquito-malaria interactions that may aid in the development of a new generation of drug/vaccine and vector-based measures for malaria control. https://ijpa.tums.ac.ir/index.php/ijpa/article/view/1287 https://ijpa.tums.ac.ir/index.php/ijpa/article/download/1287/879