Tehran University of Medical Sciences Iranian Journal of Parasitology 1735-7020 11 2 2016 12 21 226 231 Mehrzad SARAEI Dept. of Medical Parasitology and Mycology, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran AND Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran Yosef GHADERI Dept. of Medical Parasitology and Mycology, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran Tahereh MOSAVI Dept. of Medical Parasitology and Mycology, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran Mojtaba SHAHNAZI Dept. of Medical Parasitology and Mycology, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran AND Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran Marjan NASSIRI-ASL Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran AND Dept. of Pharmacology, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran Hassan JAHANIHASHEMI Dept. of Community Medicine, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran 2016 07 02 2016 07 02 Background: Toxoplasma gondii is the most common parasite causing latent cerebral infections in human. It has been shown that some anti-psychotic drugs are able to inhibit the proliferation of the parasite in in vitro study. There is very limited data regarding the inhibitory effect of anti-psychotics on Toxoplasma in in vivo. In this study, we evaluated anti-Toxoplasma activity of fluphenazine and thioridazine drugs on T. gondii in mice. Methods: Mice were divided into six groups: Control, sesame as vehicle, thioridazine 10 mg/kg, thioridazine 20 mg/kg, fluphenazine 0.06 mg/kg and fluphenazine 0.6 mg/kg. They were inoculated intraperitoneally with brain suspension containing tissue cysts of T. gondii Tehran strain. Two months after inoculation, the number of cysts in crushed smears of mice brain were counted microscopically and considered as an indicator of anti-Toxoplasma activity. This work has conducted in Qazvin, central Iran, 2014. Results: Our study showed that fluphenazine and thioridazine could not significantly inhibit the brain cystogenesis of T. gondii in mice. However, the number of brain cysts was less at higher dose compared to lower doses for both drugs. Conclusion: Further studies need to clear the mechanism of different structure of anti-psychotic drugs on activity of Toxoplasma. https://ijpa.tums.ac.ir/index.php/ijpa/article/view/1063 https://ijpa.tums.ac.ir/index.php/ijpa/article/download/1063/696