Anti-Toxocara Seropositivity in the Patients with Eye Diseases in Ophthalmology Clinics in Tehran, Iran

  • Soodabeh EINIPOUR Department of Parasitology and Mycology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Farid TAHVILDAR BIDEROUNI Department of Parasitology and Mycology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Alireza RAMEZANI Department of Ophthalmology, Imam Hosein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Keywords: Uveitis, ELISA, Eye diseases, Toxocariasis, Iran

Abstract

Background: Eye diseases, including, Uveitis, inflammation of the retina, and choroid are caused by different agents in humans and has a variety of anterior medial and posterior types. The agent of eye diseases is very different from simple bacterial to acute viral, fungal and parasitic infection. There is limited information regarding the type of eye diseases and Toxocara canis. Methods: Blood samples of 359 individuals (339 patients including endophthalmitis, uveitis, DCR, glaucoma, and cataract 20 individuals as control group) together with their information were collected from ophthalmology hospitals in Tehran, Iran from Feb 2013 to Jan 2015. The patient's serum was evaluated for the presence of anti-Toxocara antibodies by ELISA kits and blood smears for high eosinophilia. The positive samples were confirmed by Western blot analysis for T. canis infection. Results: Overall, 339 patients sera with eye diseases and control group were tested for anti-T. canis antibodies. Nineteen (5.6%) patients had anti-T. canis IgG that 14 (6.1%) were male and 5 (4.5%) were female, and all the patients had negative eosinophilia as well. The results of Western blot analysis for 19 positive patients indicated that 15 were infected by T. canis and 4 were infected by other parasitic infection. The results for control group were negative. Conclusion: All the patients with inflammatory eye diseases such as endophthalmitis, uveitis DCR, glaucoma and cataract were studied for Toxocara infection in this research work were at risk. Therefore, in contrast to the previous idea, all eye inflammatory diseases in ocular patients should be considered for Toxocara antibodies in addition to Uveitis.

References

Javadi M, Ahmadi K. principle of ophthalmology .2th ed. Nashre Tabib press.2002

Yokoi K, Goto H, Sakai J, Usui M. Clinical features of ocular toxocariasis in Japan. Ocul Immunol Inflamm 2003;11:269 –275.

Magnaval JF, Glickman LT, Dorchies P, Morassin B (2001) Highlights of human toxocariasis. Korean J Parasitol 2001; 39: 1-11.

Stewart JM, Cubillan LD, Cunningham Jr ET. Prevalence, clinical features, and causes of vision loss among patients with ocular toxocariasis. Retina. 2005;25:1005–1013.

Rothova A, de Boer JH, Ten Dam-van Loon NH, et al. Usefulness of aqueous humor analysis for the diagnosis of posterior uveitis. Ophthalmology. 2008;115:306–311.

Westeneng AC, Rothova A, de Boer JH, et al. Infectious uveitis in immunocompromised patients and the diagnostic value of polymerase chain reaction and GoldmannWitmer Coefficient in aqueous analysis. Am J Ophthalmol. 2007;144:781–785.

Taylor MRH, Holland C. Toxocariasis. In: Gillespie SH, Pearson RD, eds. Principles and practice of clinical parasitology. Chichester, UK:Wiley, 2001; 501–22.

-Pollard ZF, Jarrett WH, Hagler WS. ELISA For diagnosis of ocular toxocariasis 1979.

-Logar J1, Soba B, Kraut A, Stirn-Kranjc BSeroprevalence of Toxocara antibodies among patients suspected of ocular toxocariasis in Slovenia. Korean J Parasitol. 2004 Sep;42(3):137-40.

-De Visser L, Rothova A, De Boer JH, Van Loon AM, Kerkhoff FT, Canninga-van Dijk MR. Diagnosis of ocular toxocariasis by establishing intraocular antibody production. Am J Ophthalmol. 2008;145:369–74.

- Lim SJ1, Lee SE, Kim SH, Hong SH, You YS, Kwon OW, Kim HS. Prevalence of Toxoplasma gondii and Toxocara canis among patients with uveitis. Ocul Immunol Inflamm. 2014 Oct;22(5):360-6. doi: 10.3109/09273948.2013.841491. Epub 2014 May 15.

-Mikaniki E. Ocular toxocariasis in40 years old man. Jurnal_Mubabol.2006;67-69.

- Moradian S, Parchegani MR. Ocular Toxocariasis in a young man. Bina J Ophthalmol 2009; 14(2): 177-180.

- Fallah E, Javaddeh A, Mahami M. Ocular toxocariasis in 11 years old girl. Med J Tabriz.2011; 107-110.

Published
2019-09-18
How to Cite
1.
EINIPOUR S, TAHVILDAR BIDEROUNI F, RAMEZANI A. Anti-Toxocara Seropositivity in the Patients with Eye Diseases in Ophthalmology Clinics in Tehran, Iran. Iran J Parasitol. 14(3):453-458.
Section
Original Article(s)